Search Results - "Kappler, Francis"

Identification of Fructose 3-Phosphate in the Lens of Diabetic Rats by Szwergold, Benjamin S., Kappler, Francis, Brown, Truman R.

“…Fructose 3-phosphate, a novel monosaccharide phosphate, has been identified in the lens of diabetic rats. This compound, which is not present in normal lenses,…”
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Quantitation of 3-Deoxyglucosone Levels in Human Plasma by Lal, Sundeep, Kappler, Francis, Walker, Michael, Orchard, Trevor J., Beisswenger, Paul J., Szwergold, Benjamin S., Brown, Truman R.

“…3-Deoxyglucosone (3DG), a reactive dicarbonyl, is an important intermediate in the formation of advanced glycation end products (AGEs). The AGEs are…”
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DYN 12, a small molecule inhibitor of the enzyme amadorase, lowers plasma 3-deoxyglucosone levels in diabetic rats by Kappler, F, Schwartz, M L, Su, B, Tobia, A M, Brown, T

“…3-Deoxyglucosone (3DG) is a highly reactive alpha-dicarbonyl sugar and potent protein cross-linker that is important in the formation of advanced glycation end…”
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Total synthesis of a .alpha.-carboxymethyltetronic acid. (S)-Carlosic acid by Bloomer, James L, Kappler, Francis E

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Phosphomonoester concentrations differ between chronic lymphocytic leukemia cells and normal human lymphocytes by Franks, Suzanne E, Smith, Mitchell R, Arias-Mendoza, Fernando, Shaller, Calvin, Padavic-Shaller, Kristen, Kappler, Francis, Zhang, Yun, Negendank, William G, Brown, Truman R

“…Levels of phospholipid-related metabolites of chronic lymphocytic leukemia lymphocytes (CLL) and normal human lymphocytes were quantified using phosphorus…”
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Metabolism of Fructose-3-phosphate in the Diabetic Rat Lens by Lal, S., Szwergold, B.S., Taylor, A.H., Randall, W.C., Kappler, F., Wellsknecht, K., Baynes, J.W., Brown, T.R.

“…Fructose-S-phosphate and sorbitol-3-phosphate are produced in diabetic rat lenses by a 3-phosphokinase. While sorbitol-3-phosphate appears to be an inert…”
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Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts by Lal, Sundeep, Randall, William C., Taylor, Anne H., Kappler, Francis, Walker, Michael, Brown, Truman R., Szwergold, Benjamin S.

“…Previous studies have suggested that polyol-pathway and nonenzymatic glycation may be involved in the development of cardiac myopathy, a well-known…”
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Approaches to isozyme-specific inhibitors. 17. Attachment of a selectivity-inducing substituent to a multisubstrate adduct. Implications for facilitated design of potent, isozyme-selective inhibitors by Kappler, Francis, Hampton, Alexander

“…The synthesis is described of a methyl-C5' adduct of L-methionine and beta,gamma-ATP bearing a 6-S-n-Bu group in place of the 6-NH2 group of the parent adduct…”
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Structural studies of a phosphocholine substituted beta-(1,3);(1,6) macrocyclic glucan from Bradyrhizobium japonicum USDA 110 by Rolin, D B, Pfeffer, P E, Osman, S F, Szwergold, B S, Kappler, F, Benesi, A J

“…In our previous in vivo 31P study of intact nitrogen-fixing nodules (Rolin, D.B., Boswell, R.T., Sloger, C., Tu, S.I. and Pfeffer, P.E., 1989 Plant Physiol…”
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Study of the metabolism of choline and phosphatidylcholine in tumors in vivo using phosphonium-choline by Street, J C, Szwergold, B S, Matei, C, Kappler, F, Mahmood, U, Brown, T R, Koutcher, J A

“…The results of an initial study on the feasibility of using the phosphonium analog of choline to follow the metabolism of phosphatidylcholine in tumors in vivo…”
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Identification of sorbitol 3-phosphate and fructose 3-phosphate in normal and diabetic human erythrocytes by Petersen, A, Szwergold, B S, Kappler, F, Weingarten, M, Brown, T R

“…Using 31P NMR spectroscopy, we have identified sorbitol 3-phosphate and fructose 3-phosphate in normal human erythrocytes wherein their concentrations are…”
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Toward the synthesis of isozyme-specific enzyme inhibitors. Potent inhibitors of rat methionine adenosyltransferases. Effect of one-atom elongation of the ribose-P.alpha. bridge in two covalent adducts of L-methionine and .beta.,.gamma.-imido-ATP by Kappler, Francis, Vrudhula, Vivekananda M, Hampton, Alexander

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31P-nuclear magnetic resonance evidence of an activated hexose-monophosphate shunt in hyperglycemic rat lenses in vivo by SZWERGOLD, B. S, LAL, S, TAYLOR, A. H, KAPPLER, F, BANGYING SU, BROWN, T. R

“…Using 31P-nuclear magnetic resonance spectroscopy, we have identified elevated concentrations of sedoheptulose-7-phosphate (S-7-P) in lenses from three animal…”
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Identification of galactitol 2-phosphate and galactitol 3-phosphate in the lens of galactose-fed rats by Kappler, Francis, Su, Bangying, Szwergold, Benjamin S., Randall, William C., Brown, Truman R.

“…Production of unusual phosphorylated metabolites in the lens is one of several changes caused by hyperglycemia. Sorbitol 3-phosphate (Sor-3P) and fructose…”
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Identification of a putative tumor marker in breast and colon cancer by GANGYING SU, KAPPLER, F, SZWERGOLD, B. S, BROWN, T. R

“…Application of a recently developed phospholipid saponification procedure to malignant colon or breast tissue produces an unidentified phosphodiester resonance…”
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Effect of pH on the bioenergetics of perfused porcine lenses by Lal, S, Szwergold, B S, Kappler, F, Brown, T

“…Extracellular and intracellular pH has been shown to be an important physiological variable in many biological systems. However, studies on the effect of pH on…”
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Characterization of a phosphonium analog of choline as a probe in 31P NMR studies of phospholipid metabolism by Szwergold, B S, Kappler, F, Moldes, M, Shaller, C, Brown, T R

“…Tumors and transformed cells have been shown by 31P NMR to contain elevated concentrations of two phosphomonoesters, phosphorylcholine and…”
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Isozyme-specific enzyme inhibitors. 14. 5'(R)-C-[(L-homocystein-S-yl)methyl]adenosine 5'-(.beta.,.gamma.-imidotriphosphate), a potent inhibitor of rat methionine adenosyltransferases by Kappler, Francis, Vrudhula, Vivekananda M., Hampton, Alexander

“…The title compound is a covalent adduct of L-methionine (Met) and beta,gamma-imido-ATP. In its synthesis the N-Boc derivative of…”
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Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes by Hampton, Alexander, Chawla, Ram R, Kappler, Francis

“…Derivatives obtained by single replacements or substitutions of groups at eight positions of thymidine (TdR) have been examined as inhibitors of rat…”
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Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity by Hampton, Alexander, Kappler, Francis, Picker, Donald

“…The ATP analogues 6-(n-butylamino)-, 6-(di-n-butylamino)-, and 6-(n-butylthio)-9- beta -D-ribofuranosylpurine 5'-triphosphate have been synthesized and studied…”
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