Search Results - "Kappes, C."

Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein by Zhang, Shijian, Go, Eden P, Ding, Haitao, Anang, Saumya, Kappes, John C, Desaire, Heather, Sodroski, Joseph G

“…The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike (S) glycoprotein anchored in the viral membrane to enter host cells. The S…”
Get full text

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling by Byon, Chang Hyun, Javed, Amjad, Dai, Qun, Kappes, John C., Clemens, Thomas L., Darley-Usmar, Victor M., McDonald, Jay M., Chen, Yabing

“…Oxidative stress plays a critical role in the pathogenesis of atherosclerosis including the formation of lipid laden macrophages and the development of…”
Get full text

Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages by OCHSENBAUER, Christina, EDMONDS, Tara G, HAHN, Beatrice H, KAPPES, John C, HAITAO DING, KEELE, Brandon F, DECKER, Julie, SALAZAR, Maria G, SALAZAR-GONZALEZ, Jesus F, SHATTOCK, Robin, HAYNES, Barton F, SHAW, George M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Phenotypic properties of transmitted founder HIV-1 by Parrish, Nicholas F., Gao, Feng, Li, Hui, Giorgi, Elena E., Barbian, Hannah J., Parrish, Erica H., Zajic, Lara, Iyer, Shilpa S., Decker, Julie M., Kumar, Amit, Hora, Bhavna, Berg, Anna, Cai, Fangping, Hopper, Jennifer, Denny, Thomas N., Ding, Haitao, Ochsenbauer, Christina, Kappes, John C., Galimidi, Rachel P., West, Anthony P., Bjorkman, Pamela J., Wilen, Craig B., Doms, Robert W., O'Brien, Meagan, Bhardwaj, Nina, Borrow, Persephone, Haynes, Barton F., Muldoon, Mark, Theiler, James P., Korber, Bette, Shaw, George M., Hahn, Beatrice H.

“…Defining the virus–host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo…”
Get full text

Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore by Gao, Xiaolong, Yeh, Han-I, Yang, Zhengrong, Fan, Chen, Jiang, Fan, Howard, Rebecca J., Lindahl, Erik, Kappes, John C., Hwang, Tzyh-Chang

“…Loss-of-function mutations of the CFTR gene cause the life-shortening genetic disease cystic fibrosis (CF), whereas overactivity of CFTR may lead to secretory…”
Get full text

Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers by Go, Eden P, Ding, Haitao, Zhang, Shijian, Ringe, Rajesh P, Nicely, Nathan, Hua, David, Steinbock, Robert T, Golabek, Michael, Alin, James, Alam, S Munir, Cupo, Albert, Haynes, Barton F, Kappes, John C, Moore, John P, Sodroski, Joseph G, Desaire, Heather

“…HIV-1 envelope glycoprotein (Env) glycosylation is important because individual glycans are components of multiple broadly neutralizing antibody epitopes,…”
Get full text

Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140 by Go, Eden P, Herschhorn, Alon, Gu, Christopher, Castillo-Menendez, Luis, Zhang, Shijian, Mao, Youdong, Chen, Haiyan, Ding, Haitao, Wakefield, John K, Hua, David, Liao, Hua-Xin, Kappes, John C, Sodroski, Joseph, Desaire, Heather

“…The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer, which consists of the gp120 and gp41 subunits, is the focus of multiple…”
Get full text

The orphan ligand, activin C, signals through activin receptor-like kinase 7 by Goebel, Erich J, Ongaro, Luisina, Kappes, Emily C, Vestal, Kylie, Belcheva, Elitza, Castonguay, Roselyne, Kumar, Ravindra, Bernard, Daniel J, Thompson, Thomas B

“…Activin ligands are formed from two disulfide-linked inhibin β (Inhβ) subunit chains. They exist as homodimeric proteins, as in the case of activin A (ActA;…”
Get full text

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection by Salazar-Gonzalez, Jesus F, Salazar, Maria G, Keele, Brandon F, Learn, Gerald H, Giorgi, Elena E, Li, Hui, Decker, Julie M, Wang, Shuyi, Baalwa, Joshua, Kraus, Matthias H, Parrish, Nicholas F, Shaw, Katharina S, Guffey, M Brad, Bar, Katharine J, Davis, Katie L, Ochsenbauer-Jambor, Christina, Kappes, John C, Saag, Michael S, Cohen, Myron S, Mulenga, Joseph, Derdeyn, Cynthia A, Allen, Susan, Hunter, Eric, Markowitz, Martin, Hraber, Peter, Perelson, Alan S, Bhattacharya, Tanmoy, Haynes, Barton F, Korber, Bette T, Hahn, Beatrice H, Shaw, George M

“…Identification of full-length transmitted HIV-1 genomes could be instrumental in HIV-1 pathogenesis, microbicide, and vaccine research by enabling the direct…”
Get full text

An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum by FERRARI, Guido, POLLARA, Justin, KAPPES, John C, SHAW, George M, HOXIE, James A, ROBINSON, James E, HAYNES, Barton F, KOZINK, Daniel, HARMS, Tiara, DRINKER, Mark, FREEL, Stephanie, MOODY, M. Anthony, MUNIR ALAM, S, TOMARAS, Georgia D, OCHSENBAUER, Christina

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
Get full text

Emergence of Resistant Human Immunodeficiency Virus Type 1 in Patients Receiving Fusion Inhibitor (T-20) Monotherapy by XIPING WEI, DECKER, Julie M, HONGMEI LIU, ZEE ZHANG, ARANI, Ramin B, KILBY, J. Michael, SAAG, Michael S, XIAOYUN WU, SHAW, George M, KAPPES, John C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells by Baxter, Amy E., Russell, Rebecca A., Duncan, Christopher J.A., Moore, Michael D., Willberg, Christian B., Pablos, Jose L., Finzi, Andrés, Kaufmann, Daniel E., Ochsenbauer, Christina, Kappes, John C., Groot, Fedde, Sattentau, Quentin J.

“…Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating neurological disorders. Cell-free HIV-1 infection of macrophages is…”
Get full text

Relative resistance of HIV-1 founder viruses to control by interferon-alpha by Fenton-May, Angharad E, Dibben, Oliver, Emmerich, Tanja, Ding, Haitao, Pfafferott, Katja, Aasa-Chapman, Marlen M, Pellegrino, Pierre, Williams, Ian, Cohen, Myron S, Gao, Feng, Shaw, George M, Hahn, Beatrice H, Ochsenbauer, Christina, Kappes, John C, Borrow, Persephone

“…Following mucosal human immunodeficiency virus type 1 (HIV-1) transmission, type 1 interferons (IFNs) are rapidly induced at sites of initial virus replication…”
Get full text

The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke by Raju, S Vamsee, Lin, Vivian Y, Liu, Limbo, McNicholas, Carmel M, Karki, Suman, Sloane, Peter A, Tang, Liping, Jackson, Patricia L, Wang, Wei, Wilson, Landon, Macon, Kevin J, Mazur, Marina, Kappes, John C, DeLucas, Lawrence J, Barnes, Stephen, Kirk, Kevin, Tearney, Guillermo J, Rowe, Steven M

“…Acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction may contribute to chronic obstructive pulmonary disease pathogenesis and is a…”
Get full text

Murine Mammary Carcinoma Exosomes Promote Tumor Growth by Suppression of NK Cell Function by Liu, Cunren, Yu, Shaohua, Zinn, Kurt, Wang, Jianhua, Zhang, Liming, Jia, Yujiang, Kappes, John C, Barnes, Stephen, Kimberly, Robert P, Grizzle, William E, Zhang, Huang-Ge

“…Many tumor cells shed specialized membrane vesicles known as exosomes. In this study, we show that pretreatment of mice with exosomes produced by TS/A or 4T.1…”
Get full text

Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains by Sauter, Daniel, Schindler, Michael, Specht, Anke, Landford, Wilmina N, Münch, Jan, Kim, Kyeong-Ae, Votteler, Jörg, Schubert, Ulrich, Bibollet-Ruche, Frederic, Keele, Brandon F, Takehisa, Jun, Ogando, Yudelca, Ochsenbauer, Christina, Kappes, John C, Ayouba, Ahidjo, Peeters, Martine, Learn, Gerald H, Shaw, George, Sharp, Paul M, Bieniasz, Paul, Hahn, Beatrice H, Hatziioannou, Theodora, Kirchhoff, Frank

“…Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize human tetherin to promote viral release and replication. We show that…”
Get full text

Replication competent molecular clones of HIV-1 expressing Renilla luciferase facilitate the analysis of antibody inhibition in PBMC by Edmonds, Tara G, Ding, Haitao, Yuan, Xing, Wei, Qing, Smith, Kendra S, Conway, Joan A, Wieczorek, Lindsay, Brown, Bruce, Polonis, Victoria, West, John T, Montefiori, David C, Kappes, John C, Ochsenbauer, Christina

“…Abstract Effective vaccine development for human immunodeficiency virus type 1 (HIV-1) will require assays that ascertain the capacity of vaccine immunogens to…”
Get full text

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity by Laumaea, Annemarie, Marchitto, Lorie, Ding, Shilei, Beaudoin-Bussières, Guillaume, Prévost, Jérémie, Gasser, Romain, Chatterjee, Debashree, Gendron-Lepage, Gabrielle, Medjahed, Halima, Chen, Hung-Ching, Smith, Amos B., Ding, Haitao, Kappes, John C., Hahn, Beatrice H., Kirchhoff, Frank, Richard, Jonathan, Duerr, Ralf, Finzi, Andrés

“…HIV-1 envelope (Env) conformation determines the susceptibility of infected CD4+ T cells to antibody-dependent cellular cytotoxicity (ADCC). Upon interaction…”
Get full text

Antibody-Dependent Cellular Cytotoxicity against Primary HIV-Infected CD4+ T Cells Is Directly Associated with the Magnitude of Surface IgG Binding by SMALLS-MANTEY, Adjoa, DORIA-ROSE, Nicole, SCHEID, Johannes, KAPPES, John C, OCHSENBAUER, Christina, NABEL, Gary J, MASCOLA, John R, CONNORS, Mark, KLEIN, Rachel, PATAMAWENU, Andy, MIGUELES, Stephen A, KO, Sung-Youl, HALLAHAN, Claire W, WONG, Hing, BAI LIU, LIJING YOU

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy by Seay, Kieran, Qi, Xiaohua, Zheng, Jian Hua, Zhang, Cong, Chen, Ken, Dutta, Monica, Deneroff, Kathryn, Ochsenbauer, Christina, Kappes, John C, Littman, Dan R, Goldstein, Harris

“…Mice cannot be used to evaluate HIV-1 therapeutics and vaccines because they are not infectible by HIV-1 due to structural differences between several human…”
Get full text