Search Results - "Kappeler, D."

Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis by Barth, P, Bruijnzeel, P, Wach, A, Sellier Kessler, O, Hooftman, L, Zimmermann, J, Naue, N, Huber, B, Heimbeck, I, Kappeler, D, Timmer, W, Chevalier, E

“…AbstractBackgroundPOL6014 is a novel, orally inhaled neutrophil elastase (NE) inhibitor in development for cystic fibrosis (CF). MethodsTwo studies, one in…”
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WS01.4 A randomised, double-blind, placebo-controlled, parallel-group, dose-escalation study of inhaled single doses of POL6014, a potent and selective reversible inhibitor of human neutrophil elastase (NE), in cystic fibrosis (CF) patients by Hooftman, L, Chevalier, E, Wach, A, Zimmermann, J, Bruijnzeel, P, Naue, N, Heimbeck, I, Kappeler, D, Barth, P

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61 A randomised, double-blind, placebo-controlled, parallel-group, dose-escalation phase I study in healthy volunteers (HV) of inhaled single doses (SD) of POL6014, a potent and selective reversible inhibitor of human neutrophil elastase by Barth, P, Wach, A, Chevalier, E, Kessler, O. Sellier, Huber, B, Kappeler, D, Timmer, W, Hooftman, L

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Localized granuloma annulare associated with autoimmune thyroid disease in a patient with a positive family history for autoimmune polyglandular syndrome type II by Kappeler, D, Troendle, A, Mueller, B

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Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme by Krug, Norbert, Hohlfeld, Jens M, Kirsten, Anne-Marie, Kornmann, Oliver, Beeh, Kai M, Kappeler, Dominik, Korn, Stephanie, Ignatenko, Stanislav, Timmer, Wolfgang, Rogon, Cordelia, Zeitvogel, Jana, Zhang, Nan, Bille, Joachim, Homburg, Ursula, Turowska, Agnieszka, Bachert, Claus, Werfel, Thomas, Buhl, Roland, Renz, Jonas, Garn, Holger, Renz, Harald

“…GATA3 is thought to be a critical checkpoint in allergic diathesis. In this study, a synthetic DNAzyme that catalyzes the inactivation of GATA3 when…”
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Macroprolactinaemia: the major unknown in the differential diagnosis of hyperprolactinaemia by Cattaneo, F, Kappeler, D

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Ensuring Patient Safety and Data Integrity in Clinical Trials for the Treatment of Bronchiolitis Obliterans Syndrome (BOS) during the COVID-19 Pandemic by Fernandes, S. Prante, Hagedorn, T., Salerio, I., Cuomo, D., Kappeler, D., Tutone, M., Witte, S., Vaja, V.

“…The current COVID-19 pandemic has posed challenges to the conduct of clinical trials. BOSTON-1 and BOSTON-2 are two ongoing phase III, prospective,…”
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Liposomal Cyclosporine A (L-CsA) via Inhalation to Treat Bronchiolitis Obliterans Syndrome: Novel Formulation and Drug-Specific Delivery System Improves Tolerability by Henig, N., Teichmann, J., Paulukat, J., Kappeler, D., Denk, O., Boerner, G.

“…Bronchiolitis obliterans syndrome (BOS) is the major obstacle to long-term benefit after lung transplantation. There is no therapy with demonstrated benefit…”
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A40 CYSTIC FIBROSIS AND NON-CYSTIC FIBROSIS BRONCHIECTASIS: Characteristics Of The T-326 Inhaler Important For Effective Inhalation Treatment With Ciprofloxacin Dry Powder For Inhalation In Patients With Non-Cystic Fibrosis Bronchiectasis by Stass, H, Nagelschmitz, J, Kappeler, D, Sommerer, K, Patzlaff, A, Weimann, B

“…In order to ensure reliable and reproducible drug delivery to the lung, all patients (including those with reduced lung function) need to have an inspiratory…”
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C33 CYTOKINES AND ASTHMA MEDIATORS: Effect Of Sample Processing On The Analysis Of Il4, Il5, And Il13 In Sputum Supernatants by Holz, O, Muller, M, Ignatenko, S, Kappeler, D, Buhl, R, Beeh, K-M, Kornmann, O, Kirsten, A, Homburg, U, Garn, H, Krug, N, Hohlfeld, J M

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Macroprolactinaemia, the major unknown in the differential diagnosis of hyperprolactinaemia by Cattaneo, F, Kappeler, D, Müller, B

“…We report on 10 cases of macroprolactinaemia and discuss recent evidence that many patients with hyperprolactinaemia (8-26%, depending on the population…”
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Localized granuloma annulare associated with autoimmune thyroid disease in a patient with a positive family history for autoimmune polyglandular syndrome type II by Kappeler, D, Troendle, A, Mueller, B

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Les Réserves dans les Traités Internationaux by Seidl-Hohenveldern, Ignaz

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