Search Results - "Kapoor, Mili"

Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens by Liston, Sean D., Whitesell, Luke, Kapoor, Mili, Shaw, Karen J., Cowen, Leah E.

“…Invasive fungal infections have mortality rates of 30–90%, depending on patient co-morbidities and the causative pathogen. The frequent emergence of drug…”
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Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality by Yang, Xiang-Lei, Zhou, Quansheng, Kapoor, Mili, Guo, Min, Belani, Rajesh, Xu, Xiaoling, Kiosses, William B, Hanan, Melanie, Park, Chulho, Armour, Eva, Do, Minh-Ha, Nangle, Leslie A, Schimmel, Paul

“…tRNA synthetases (RSs) have been implicated in functions beyond tRNA synthesis, and human TrpRS has been implicated in inhibiting angiogenesis. Tryptophan…”
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Combined effect of epigallocatechin gallate and triclosan on enoyl-ACP reductase of Mycobacterium tuberculosis by Sharma, Shailendra Kumar, Kumar, Gyanendra, Kapoor, Mili, Surolia, Avadhesha

“…Among the various inhibitors known for enoyl-acyl carrier protein (ACP) reductases, triclosan and green tea catechins are two promising candidates. In the…”
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Functional and Crystal Structure Analysis of Active Site Adaptations of a Potent Anti-Angiogenic Human tRNA Synthetase by Yang, Xiang-Lei, Guo, Min, Kapoor, Mili, Ewalt, Karla L., Otero, Francella J., Skene, Robert J., McRee, Duncan E., Schimmel, Paul

“…Higher eukaryote tRNA synthetases have expanded functions that come from enlarged, more differentiated structures that were adapted to fit aminoacylation…”
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Evidence for Annexin II-S100A10 Complex and Plasmin in Mobilization of Cytokine Activity of Human TrpRS by Kapoor, Mili, Zhou, Quansheng, Otero, Francella, Myers, Christopher A., Bates, Alison, Belani, Rajesh, Liu, Jianming, Luo, Jiann-Kae, Tzima, Eleni, Zhang, Dong-Er, Yang, Xiang-Lei, Schimmel, Paul

“…In mammalian cells, specific aminoacyl-transfer RNA (tRNA) synthetases have cytokine functions that require interactions with partners outside of the…”
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Interactions of Substrate with Calreticulin, an Endoplasmic Reticulum Chaperone by Kapoor, Mili, Srinivas, Honnappa, Kandiah, Eaazhisai, Gemma, Emiliano, Ellgaard, Lars, Oscarson, Stefan, Helenius, Ari, Surolia, Avadhesha

“…Calreticulin is a molecular chaperone found in the endoplasmic reticulum in eukaryotes, and its interaction with N -glycosylated polypeptides is mediated by…”
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Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response by Thomas, Celestine J, Kapoor, Mili, Sharma, Shilpi, Bausinger, Huguette, Zyilan, Umit, Lipsker, Dan, Hanau, Daniel, Surolia, Avadhesha

“…The kinetics of the interaction of lipopolysaccharide (LPS), lipopolysaccharide binding protein (LBP) and CD14 was studied using surface plasmon resonance. The…”
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In Vitro Activity of Manogepix against Multidrug-Resistant and Panresistant Candida auris from the New York Outbreak by Zhu, YanChun, Kilburn, Shannon, Kapoor, Mili, Chaturvedi, Sudha, Shaw, Karen Joy, Chaturvedi, Vishnu

“…An ongoing outbreak in the New York metropolitan area is the largest recorded to date in North America. Laboratory surveillance revealed NY isolates are…”
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Evaluation of Resistance Development to the Gwt1 Inhibitor Manogepix (APX001A) in Candida Species by Kapoor, Mili, Moloney, Molly, Soltow, Quinlyn A, Pillar, Chris M, Shaw, Karen Joy

“…Manogepix (MGX) targets the conserved fungal Gwt1 enzyme required for acylation of inositol early in the glycosylphosphatidylinositol biosynthesis pathway. The…”
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Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility by Liston, Sean D, Whitesell, Luke, Kapoor, Mili, Shaw, Karen Joy, Cowen, Leah E

“…Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we…”
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APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia by Viriyakosol, Suganya, Kapoor, Mili, Okamoto, Sharon, Covel, Jonathan, Soltow, Quinlyn A, Trzoss, Michael, Shaw, Karen Joy, Fierer, Joshua

“…Coccidioidomycosis is a systemic fungal infection caused by the inhalation of the arthroconidia of either of two closely related dimorphic fungi, and , that…”
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APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis by Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Alqarihi, Abdullah, Jeon, Heewon H, Gu, Yiyou, Kapoor, Mili, Shaw, Karen J, Ibrahim, Ashraf S

“…Invasive pulmonary aspergillosis (IPA) due to is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new…”
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In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus by Shaw, Karen Joy, Schell, Wiley A, Covel, Jonathan, Duboc, Gisele, Giamberardino, C, Kapoor, Mili, Moloney, Molly, Soltow, Quinlyn A, Tenor, Jennifer L, Toffaletti, Dena L, Trzoss, Michael, Webb, Peter, Perfect, John R

“…Cryptococcal meningitis (CM), caused primarily by , is uniformly fatal if not treated. Treatment options are limited, especially in resource-poor geographical…”
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Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody by Ishchenko, Andrii, Wacker, Daniel, Kapoor, Mili, Zhang, Ai, Han, Gye Won, Basu, Shibom, Patel, Nilkanth, Messerschmidt, Marc, Weierstall, Uwe, Liu, Wei, Katritch, Vsevolod, Roth, Bryan L., Stevens, Raymond C., Cherezov, Vadim

“…Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled…”
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Synthesis of analogs of the Gwt1 inhibitor manogepix (APX001A) and in vitro evaluation against Cryptococcus spp by Trzoss, Michael, Covel, Jonathan A., Kapoor, Mili, Moloney, Molly K., Soltow, Quinlyn A., Webb, Peter J., Shaw, Karen Joy

“…[Display omitted] Fosmanogepix (APX001) is a first-in-class prodrug molecule that is currently in Phase 2 clinical trials for invasive fungal infections. The…”
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In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus by Shaheen, Shareef K, Juvvadi, Praveen R, Allen, 4th, John, Shwab, E Keats, Cole, D Christopher, Asfaw, Yohannes G, Kapoor, Mili, Shaw, Karen Joy, Steinbach, William J

“…Invasive aspergillosis (IA) due to Aspergillus fumigatus is a deadly infection for which new antifungal therapies are needed. Here, we demonstrate the efficacy…”
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Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling by Sajish, Mathew, Zhou, Quansheng, Kishi, Shuji, Valdez, Delgado M, Kapoor, Mili, Guo, Min, Lee, Sunhee, Kim, Sunghoon, Yang, Xiang-Lei, Schimmel, Paul

“…Trp-tRNA synthetase (TrpRS) has a well-understood role in translation by facilitating aminoacylation of Trp-tRNAs. The discovery of a nuclear signaling role…”
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1275. Evaluation of in vitro activity of manogepix against multidrug-resistant and pan-resistant Candida auris from the New York Outbreak by Zhu, Yan Chun, Kilburn, Shannon N, Kapoor, Mili, Chaturvedi, Sudha, Shaw, Karen J, Chaturvedi, Vishnu

“…Abstract Background An ongoing Candida auris outbreak in the New York metropolitan area is the largest recorded to date in North America. NY C. auris isolates…”
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A calcineurin antifungal strategy with analogs of FK506 by Nambu, Mitchell, Covel, Jonathan A., Kapoor, Mili, Li, Xiaoming, Moloney, Molly K., Numa, Mehdi M., Soltow, Quinlyn A., Trzoss, Michael, Webb, Peter, Webb, Robert R., Mutz, Mitchell

“…[Display omitted] A novel antifungal strategy targeting the inhibition of calcineurin is described. To develop a calcineurin based inhibitor of pathogenic…”
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1614. Gwt1 Inhibitor, APX2104, Protects Against Invasive Aspergillosis in Neutropenic Mouse Model by Shaheen, Shareef, Allen, John, Cole, D Chris, Asfaw, Yohannes, Juvvadi, Praveen, Shwab, E Keats, Kapoor, Mili, Shaw, Karen, Steinbach, William

“…Abstract Background Aspergillus fumigatus is the leading cause of invasive aspergillosis (IA), a lethal infection among immunocompromised patients…”
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