Search Results - "Kapoerchan, Varsha V."

Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule by Kapoerchan, Varsha V., Wiesner, Martina, Hillaert, Ulrik, Drijfhout, Jan W., Overhand, Mark, Alard, Philippe, van der Marel, Gijs A., Overkleeft, Hermen S., Koning, Frits

“…Celiac disease is caused by uncontrolled CD4 T-cell responses directed to wheat-derived gluten peptides bound to the disease predisposing HLA-DQ molecules. The…”
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Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands by Bonger, Kimberly M, Kapoerchan, Varsha V, Grotenbreg, Gijsbert M, van Koppen, Chris J, Timmers, C Marco, van der Marel, Gijsbert A, Overkleeft, Herman S

“…Oligoprolines (OPs) are used as rigid backbone scaffolds for the design of oligomeric ligands that target specific G protein-coupled receptors. The OPs were…”
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Gramicidin S Derivatives Containing cis- and trans-Morpholine Amino Acids (MAAs) as Turn Mimetics by Kapoerchan, Varsha V., Spalburg, Emile, de Neeling, Albert. J., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Ferraces-Casais, Patricia, Llamas-Saiz, Antonio L., van Raaij, Mark J., van Doorn, Joop, van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…The cyclic decapeptide gramicidin S (GS) was used as a model for the evaluation of four turn mimetics. For this purpose, one of the D‐Phe‐Pro two‐residue turn…”
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Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds by Nabuurs, Rob J.A., Kapoerchan, Varsha V., Metaxas, Athanasios, Hafith, Sarah, de Backer, Maaike, Welling, Mick M., Jiskoot, Wim, van den Nieuwendijk, Adrianus M.C.H., Windhorst, Albert D., Overkleeft, Herman S., van Buchem, Mark A., Overhand, Mark, van der Weerd, Louise

“…[Display omitted] Detection of cerebral β-amyloid (Aβ) by targeted contrast agents is of great interest for in vivo diagnosis of Alzheimer’s disease (AD)…”
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Design of azidoproline containing gluten peptides to suppress CD4 + T-cell responses associated with Celiac disease by Kapoerchan, Varsha V., Wiesner, Martina, Overhand, Mark, van der Marel, Gijs A., Koning, Frits, Overkleeft, Herman S.

“…Natural gluten peptides were modified by ‘click’ chemistry to yield potential blockers for the HLA-DQ2 protein, which presents immunogenic gluten to T-cells…”
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Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands by Nabuurs, Rob J.A., Kapoerchan, Varsha V., Metaxas, Athanasios, de Jongh, Sanne, de Backer, Maaike, Welling, Mick M., Jiskoot, Wim, Windhorst, Albert D., Overkleeft, Hermen S., van Buchem, Mark A., Overhand, Mark, van der Weerd, Louise

“…Detection of cerebral β-amyloid (Aβ) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer’s disease (AD)…”
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An Adamantyl Amino Acid Containing Gramicidin S Analogue with Broad Spectrum Antibacterial Activity and Reduced Hemolytic Activity by Kapoerchan, Varsha V., Knijnenburg, Annemiek D., Niamat, Miquel, Spalburg, Emile, de Neeling, Albert J., Nibbering, Peter H., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…The cyclic cationic antimicrobial peptide gramicidin S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis)…”
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‘Inverted’ analogs of the antibiotic gramicidin S with an improved biological profile by Kapoerchan, Varsha V., Knijnenburg, Annemiek D., Keizer, Peter, Spalburg, Emile, de Neeling, Albert J., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…A series of gramicidin S derivatives 4–15 are presented that have four ornithine residues as polar protonated side chains and two central hydrophobic amino…”
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Tuning hydrophobicity of highly cationic tetradecameric Gramicidin S analogues using adamantane amino acids by Knijnenburg, Annemiek D., Kapoerchan, Varsha V., Spalburg, Emile, de Neeling, Albert J., Mars-Groenendijk, Roos H., Noort, Daan, van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…Ring extended Gramicidin S analogues containing adamantane amino acids and six cationic residues were designed and evaluated. Systematic replacement of the…”
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Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives by Knijnenburg, Annemiek D., Kapoerchan, Varsha V., Grotenbreg, Gijsbert M., Spalburg, Emile, de Neeling, Albert J., Mars-Groenendijk, Roos H., Noort, Daan, Otero, José M., Llamas-Saiz, Antonio L., van Raaij, Mark J., Ravensbergen, Bep, Nibbering, Peter H., van der Marel, Gijs A., Overkleeft, Herman S., Overhand, Mark

“…In this paper, we describe the crystal structure of previously reported ring-extended gramicidin S (GS) derivative 2 (GS14K4), containing a d-amino acid…”
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An Adamantyl Amino Acid Containing GramicidinS Analogue with Broad Spectrum Antibacterial Activity and Reduced Hemolytic Activity by Kapoerchan, Varsha V, Knijnenburg, Annemiek D, Niamat, Miquel, Spalburg, Emile, deNeeling, Albert J, Nibbering, Peter H, Mars-Groenendijk, Roos H, Noort, Daan, Otero, Jose M, Llamas-Saiz, Antonio L, vanRaaij, Mark J, vanderMarel, Gijs A, Overkleeft, Herman S, Overhand, Mark

“…The cyclic cationic antimicrobial peptide gramicidinS (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis)…”
Get full text