Search Results - "Kaplow, June M"

CSF amyloid lowering in human volunteers after 14 days’ oral administration of the novel BACE1 inhibitor E2609 by Albala, Bruce, Kaplow, June M, Lai, Robert, Matijevic, Mark, Aluri, Jagadeesh, Satlin, Andrew

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Soluble BACE activity and sAPPβ levels do not differentiate Alzheimer's disease and age-matched control cerebrospinal fluid in the ADNI-1 cohort by Savage, Mary, Holder, Dan, Wu, Guoxin, Kaplow, June M, Siuciak, Judith, Potter, William, ADNI

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Clinical study of E2609, a novel BACE1 inhibitor, demonstrates target engagement and inhibition of BACE1 activity in CSF by Bernier, Francois, Sato, Yoshiaki, Matijevic, Mark, Desmond, Howard, McGrath, Shannon, Burns, Lynne, Kaplow, June M, Albala, Bruce

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First-in-human study of E2609, a novel BACE1 inhibitor, demonstrates prolonged reductions in plasma beta-amyloid levels after single dosing by Lai, Robert, Albala, Bruce, Kaplow, June M, Aluri, Jagadeesh, Yen, Mark, Satlin, Andrew

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INITIAL LEARNINGS FROM SCREENING STRATEGIES IN THE BAN 2401-G000-201 TRIAL: AN EARLY ALZHEIMER'S DISEASE STUDY by Logovinsky, Veronika, Swanson, Chad, Lai, Robert, Do, Ira, Kaplow, June M, Rabe, Martin P, Gordon, Robert, Wang, Jinping, Xu, Lu, Basun, Hans, Lannfelt, Lars, Satlin, Andrew

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CONSIDERATION FOR “EARLY ALZHEIMER'S DISEASE (AD)” TRIALS WITH A SINGLE PRODROMAL AD AND MILD AD DEMENTIA POPULATION: ADNI DATA ANALYSIS AND INITIAL OBSERVATIONS FROM THE BAN2401-G000-201 TRIAL by Swanson, Chad J, Logovinsky, Veronika, Xu, Lu, Wang, Jinping, Lai, Robert, Rabe, Martin P, Gordon, Robert, Kaplow, June M, Basun, Hans, Lannfelt, Lars, Satlin, Andrew

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Pharmacology of BAN2401: A monoclonal antibody selective for beta-amyloid protofibrils by Swanson, Chad, Kaplow, June M, Mastroeni, Diego, Rogers, Joseph, Waara, Erik Rollman, Navia, Bradford, Lai, Robert, Logovinsky, Veronika, Möller, Christer, Lannfelt, Lars, Satlin, Andrew

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A first-in-human study of BAN2401, a novel monoclonal antibody against beta-amyloid protofibrils by Lai, Robert, Logovinsky, Veronika, Kaplow, June M, Gu, Kenan, Yu, Yanke, Möller, Christer, Navia, Bradford, Swanson, Chad, Lannfelt, Lars, Satlin, Andrew

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Microglial involvement and amyloid reduction with BAN2401/mAb158, a monoclonal antibody with high selectivity for protofibrils: In vitro and ex vivo analyses by Kaplow, June M, Kusnetov, Galina, Mastroeni, Diego, Navia, Bradford, Kumar, Namita, Biscaro, Barbara, Koyama, Akhiko, Möller, Christer, Lai, Robert, Swanson, Chad, Logovinsky, Veronika, Lannfelt, Lars, Satlin, Andrew, Rogers, Joseph

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A multimodal imaging study of mAb158, a murine monoclonal antibody with high selectivity for amyloid protofibrils, in Tg2576 mice by Navia, Bradford, Perdomo, Carlos, Krause, Stephen, Kaplow, June M, Koyama, Akihiko, Teceno, Tyler, Gershman, Ben, Logovinsky, Veronika, Swanson, Chad, Lai, Robert, Möller, Christer, Lannfelt, Lars, Satlin, Andrew, McCracken, Paul

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Monocyte chemoattractant protein-2 is a potent agonist of CCR2B by Moore, Una M., Kaplow, June M., Pleass, Robert D., Castro, Sandra W., Naik, Kuni, Lynch, Carolyn N., Daly, Steven, Roach, Alan G., Jaye, Michael, Williams, Robert J.

“…The binding and functional activity of the CC chemokines monocyte chemoattractant protein‐1 (MCP‐1), MCP‐2, and MCP‐3 have been characterized using Chinese…”
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cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains by Tong, Benton D, Auer, David E, Jaye, Michael, Kaplow, June M, Ricca, George, McConathy, Evelyn, Drohan, William, Deuel, Thomas F

“…Human platelet-derived growth factor (PDGF) is a potent mitogenic polypeptide which is believed to be a heterodimer of A- and B-chains stabilized by interchain…”
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P1–140: Soluble BACE activity and sAPPβ levels do not differentiate Alzheimer's disease and age‐matched control cerebrospinal fluid in the ADNI‐1 cohort by Savage, Mary, Holder, Dan, Wu, Guoxin, Kaplow, June M., Siuciak, Judith, Potter, William

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P4‐181: INITIAL LEARNINGS FROM SCREENING STRATEGIES IN THE BAN 2401‐G000‐201 TRIAL: AN EARLY ALZHEIMER'S DISEASE STUDY by Logovinsky, Veronika, Swanson, Chad, Lai, Robert, Do, Ira, Kaplow, June M., Rabe, Martin P., Gordon, Robert, Wang, Jinping, Xu, Lu, Basun, Hans, Lannfelt, Lars, Satlin, Andrew

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P3‐404: CONSIDERATION FOR “EARLY ALZHEIMER'S DISEASE (AD)” TRIALS WITH A SINGLE PRODROMAL AD AND MILD AD DEMENTIA POPULATION: ADNI DATA ANALYSIS AND INITIAL OBSERVATIONS FROM THE BAN2401‐G000‐201 TRIAL by Swanson, Chad J., Logovinsky, Veronika, Xu, Lu, Wang, Jinping, Lai, Robert, Rabe, Martin P., Gordon, Robert, Kaplow, June M., Basun, Hans, Lannfelt, Lars, Satlin, Andrew

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P4–411: Clinical study of E2609, a novel BACE1 inhibitor, demonstrates target engagement and inhibition of BACE1 activity in CSF by Bernier, Francois, Sato, Yoshiaki, Matijevic, Mark, Desmond, Howard, McGrath, Shannon, Burns, Lynne, Kaplow, June M., Albala, Bruce

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S4‐04‐01: CSF amyloid lowering in human volunteers after 14 days’ oral administration of the novel BACE1 inhibitor E2609 by Albala, Bruce, Kaplow, June M., Lai, Robert, Matijevic, Mark, Aluri, Jagadeesh, Satlin, Andrew

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O1‐06‐05: First‐in‐human study of E2609, a novel BACE1 inhibitor, demonstrates prolonged reductions in plasma beta‐amyloid levels after single dosing by Lai, Robert, Albala, Bruce, Kaplow, June M., Aluri, Jagadeesh, Yen, Mark, Satlin, Andrew

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P4–286: Pharmacology of BAN2401: A monoclonal antibody selective for beta‐amyloid protofibrils by Swanson, Chad, Kaplow, June M., Mastroeni, Diego, Rogers, Joseph, Waara, Erik Rollman, Navia, Bradford, Lai, Robert, Logovinsky, Veronika, Möller, Christer, Lannfelt, Lars, Satlin, Andrew

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O4–05–01: A first‐in‐human study of BAN2401, a novel monoclonal antibody against beta‐amyloid protofibrils by Lai, Robert, Logovinsky, Veronika, Kaplow, June M., Gu, Kenan, Yu, Yanke, Möller, Christer, Navia, Bradford, Swanson, Chad, Lannfelt, Lars, Satlin, Andrew

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