Search Results - "Kaplita, P V"

Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence by Kolb, Alfred J, Kaplita, Paul V, Hayes, David J, Park, Young-Whan, Pernell, Christine, Major, John S, Mathis, Gérard

“…Tyrosine kinases are important therapeutic targets in drug discovery high-throughput screening programs. Homogeneous time-resolved fluorescence (HTRF)…”
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Evidence for direct interactions between the NMDA and glycine recognition sites in brain by Kaplita, P V, Ferkany, J W

“…The interaction between glycine and competitive N-methyl-D-aspartate (NMDA) antagonists was investigated. Glycine (IC50 = 170 nM) partially (approximately 60%)…”
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Pharmacologic profile of NPC 168 (naltrexone phenyl oxime), a novel compound with activity at opioid receptors by DeHaven-Hudkins, D L, Brostrom, P A, Allen, J T, Lesko, L J, Ferkany, J W, Kaplita, P V, Mavunkel, B J, Rzeszotarski, W J, Steranka, L R

“…NPC 168 (naltrexone phenyl oxime) was synthesized as a novel opioid antagonist and evaluated in several in vitro and in vivo assays. NPC 168 inhibited binding…”
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Effects of dietary fats and soybean protein on azaserine-induced pancreatic carcinogenesis and plasma cholecystokinin in the rat by ROEBUCK, B. D, KAPLITA, P. V, EDWARDS, B. R, PRAISSMAN, M

“…Both dietary unsaturated fat and raw soybean products are known to enhance pancreatic carcinogenesis when fed during the postinitiation phase. A comparison of…”
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gamma-Aminobutyric acid action in guinea-pig ileal myenteric plexus by Kaplita, P V, Waters, D H, Triggle, D J

“…The responses of the guinea-pig ileum myenteric plexus-longitudinal muscle preparation to gamma-aminobutyric acid (GABA) and several analogs were examined in…”
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Pathways for the bioactivation of aliphatic nitriles to free cyanide in mice by Kaplita, P V, Smith, R P

“…Reports from several laboratories agree that many, but not all, aliphatic nitriles undergo hepatic biotransformation in mice and rats to release free cyanide,…”
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Peripheral and central actions of sodium azide on circulatory and respiratory homeostasis in anesthesized cats by Kaplita, P V, Borison, H L, McCarthy, L E, Smith, R P

“…In pentobarbital-anesthesized cats, bolus i.v. injections of sodium azide produced dose-dependent transient hypotension accompanied by a modest tachycardia and…”
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Proglumide antagonizes the stimulation of rabbit gallbladder by cholecystokinin by Kaplita, P V, Roebuck, B D

“…Proglumide (3 X 10(-4) to 3 X 10(-3) M) produced parallel rightward shifts in the cumulative concentration-response curves for cholecystokinin octapeptide…”
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A symmetrical 1,4-dihydropyridine with opposite actions on K(+)-induced contractions in guinea-pig ileum by Kaplita, P V, Wilkins, D E, Adams, T C, Hanson, R C

“…The effects of 1,4-dihydro-2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid dimethyl ester (DHMP) on Ca2(+)-evoked contractions in potassium-depolarized…”
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A Metalloproteinase Inhibitor from Doliocarpus verruculosus by Sun, Hao H., Kaplita, Paul V., Houck, David R., Stawicki, Mary B., McGarry, Ruthann, Wahl, Robert C., Gillum, Amanda M., Cooper, Raymond

“…In our natural products screening programme for the discovery of competitive inhibitors of the matrix metalloproteinases, stromelysin and collagenase, we have…”
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The effects of erythrosin B(FD & C Red No. 3) on the guinea-pig ileum myenteric plexus-longitudinal muscle preparation by Kaplita, P V, Bolger, G T, Triggle, D J

“…The responses of the guinea-pig ileum myenteric plexus-longitudinal muscle to the food, drug and cosmetic dye erythrosin B (FD & C Red No. 3) were examined in…”
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Actions of Ca2+ antagonists on the guinea-pig ileal myenteric plexus preparation by Kaplita, P V, Triggle, D J

“…The guinea-pig ileal myenteric plexus preparation has been used to compare the actions of three Ca2+ channel antagonists, D 600 (methoxyverapamil), nicardipine…”
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Interaction of Dietary Fat and Soybean Isolate (SBI) on Azaserine-induced Pancreatic Carcinogenesis by Roebuck, B. D., Kaplita, Paul V., Macmillan, Denise L.

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