Search Results - "Kaplan, Tomas"
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1
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors
Published in Bioorganic & medicinal chemistry (15-03-2008)“…The synthesis, SAR, and in vivo activity of highly potent thiamine mimetics utilized as transketolase (TK) antagonists is presented. Tumor cells extensively…”
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2
Non-charged thiamine analogs as inhibitors of enzyme transketolase
Published in Bioorganic & medicinal chemistry (15-01-2008)“…The synthesis and SAR including structure-based rationale drug design for highly potent non-thiazolium TK antagonists is presented. Inhibition of the…”
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Journal Article -
3
Prodrug thiamine analogs as inhibitors of the enzyme transketolase
Published in Bioorganic & medicinal chemistry (15-01-2008)“…Synthesis of prodrugs of the transketolase inhibitor 5a and their evaluation in murine pharmacokinetic and pharmacodynamic models. Transketolase, a key enzyme…”
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Journal Article