Search Results - "Kaplan, Hilton"

Nanoparticles and nanofibers for topical drug delivery by Goyal, Ritu, Macri, Lauren K., Kaplan, Hilton M., Kohn, Joachim

“…This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery. Researchers have explored the…”
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The overwhelming use of rat models in nerve regeneration research may compromise designs of nerve guidance conduits for humans by Kaplan, Hilton M., Mishra, Prakhar, Kohn, Joachim

“…Rats are not the best model for the evolving complexities we face in designing nerve repair strategies today. The development of effective nerve guidance…”
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Primary breast augmentation clinical trial outcomes stratified by surgical incision, anatomical placement and implant device type by Namnoum, James D, Largent, Joan, Kaplan, Hilton M, Oefelein, Michael G, Brown, Mitchell H

“…Summary Background Clinical evidence concerning the potential risks and benefits associated with surgical incision, anatomical pocket and implant device type…”
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Percutaneous Collagen Induction Therapy: An Alternative Treatment for Scars, Wrinkles, and Skin Laxity by Aust, Matthias C., Fernandes, Des, Kolokythas, Perikles, Kaplan, Hilton M., Vogt, Peter M.

“…Skin laxity, rhytides, and photoaging are generally treated by ablative procedures that injure or destroy the epidermis and its basement membrane, at least in…”
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Modeling the Insertion Mechanics of Flexible Neural Probes Coated with Sacrificial Polymers for Optimizing Probe Design by Singh, Sagar, Lo, Meng-Chen, Damodaran, Vinod B, Kaplan, Hilton M, Kohn, Joachim, Zahn, Jeffrey D, Shreiber, David I

“…Single-unit recording neural probes have significant advantages towards improving signal-to-noise ratio and specificity for signal acquisition in…”
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Fibrin glue as a stabilization strategy in peripheral nerve repair when using porous nerve guidance conduits by Bhatnagar, Divya, Bushman, Jared S., Murthy, N. Sanjeeva, Merolli, Antonio, Kaplan, Hilton M., Kohn, Joachim

“…Porous conduits provide a protected pathway for nerve regeneration, while still allowing exchange of nutrients and wastes. However, pore sizes >30 µm may…”
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Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson's Disease by Struzyna, Laura A, Browne, Kevin D, Burrell, Justin C, Vélez, Wisberty J Gordián, Wofford, Kathryn L, Kaplan, Hilton M, Murthy, N Sanjeeva, Chen, H Isaac, Duda, John E, España, Rodrigo A, Cullen, D Kacy

“…Parkinson's disease (PD) affects 1-2% of people over 65, causing significant morbidity across a progressive disease course. The classic PD motor deficits are…”
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A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance by Burrell, Justin C, Browne, Kevin D, Dutton, John L, Laimo, Franco A, Das, Suradip, Brown, Daniel P, Roberts, Sanford, Petrov, Dmitriy, Ali, Zarina, Ledebur, Harry C, Rosen, Joseph M, Kaplan, Hilton M, Wolf, John A, Smith, Douglas H, Chen, H Isaac, Cullen, D Kacy

“…Abstract BACKGROUND Millions of Americans experience residual deficits from traumatic peripheral nerve injury (PNI). Despite advancements in surgical…”
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Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Conduit Material and Luminal Filler for Peripheral Nerve Regeneration by Kohn-Polster, Caroline, Bhatnagar, Divya, Woloszyn, Derek J, Richtmyer, Matthew, Starke, Annett, Springwald, Alexandra H, Franz, Sandra, Schulz-Siegmund, Michaela, Kaplan, Hilton M, Kohn, Joachim, Hacker, Michael C

“…Toward the next generation of nerve guidance conduits (NGCs), novel biomaterials and functionalization concepts are required to address clinical demands in…”
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Coating flexible probes with an ultra fast degrading polymer to aid in tissue insertion by Lo, Meng-chen, Wang, Shuwu, Singh, Sagar, Damodaran, Vinod B., Kaplan, Hilton M., Kohn, Joachim, Shreiber, David I., Zahn, Jeffrey D.

“…We report a fabrication process for coating neural probes with an ultrafast degrading polymer to create consistent and reproducible devices for neural tissue…”
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Tyrosine‐derived polycarbonate nerve guidance tubes elicit proregenerative extracellular matrix deposition when used to bridge segmental nerve defects in swine by Burrell, Justin C., Bhatnagar, Divya, Brown, Dan P., Murthy, N. Sanjeeva, Dutton, John, Browne, Kevin D., Laimo, Franco A., Ali, Zarina S., Rosen, Joseph M., Kaplan, Hilton M., Kohn, Joachim, Cullen, D. Kacy

“…Promising biomaterials should be tested in appropriate large animal models that recapitulate human inflammatory and regenerative responses. Previous studies…”
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Pharmacokinetic and Pharmacological Aspects of a Papain-Based Enzyme Solution for Rescuing Clogged Enteral Feeding Tubes by Lavigne, Mark C., Curd, David T., Kaplan, Hilton M.

“…Successful enteral feeding depends on patent enteral feeding tubes to permit trouble-free entry of nutritional formula into the alimentary tract. However, tube…”
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Tissue engineered axon‐based “living scaffolds” promote survival of spinal cord motor neurons following peripheral nerve repair by Maggiore, Joseph C., Burrell, Justin C., Browne, Kevin D., Katiyar, Kritika S., Laimo, Franco A., Ali, Zarina S., Kaplan, Hilton M., Rosen, Joseph M., Cullen, D. Kacy

“…Peripheral nerve injury (PNI) impacts millions annually, often leaving debilitated patients with minimal repair options to improve functional recovery. Our…”
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Predoctoral and Postdoctoral Training Pipeline in Translational Biomaterials Research and Regenerative Medicine by Grinstaff, Mark W, Kaplan, Hilton M, Kohn, Joachim

“…The translation of biomaterial based and regenerative therapies from the laboratory to patients involves multiple challenges. One of the most pressing…”
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Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs by Smith, Douglas H., Burrell, Justin C., Browne, Kevin D., Katiyar, Kritika S., Ezra, Mindy I., Dutton, John L., Morand, Joseph P., Struzyna, Laura A., Laimo, Franco A., Chen, H. Isaac, Wolf, John A., Kaplan, Hilton M., Rosen, Joseph M., Ledebur, Harry C., Zager, Eric L., Ali, Zarina S., Cullen, D. Kacy

“…Functional restoration following major peripheral nerve injury (PNI) is challenging, given slow axon growth rates and eventual regenerative pathway degradation…”
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Risk of lymphoma in women with breast implants: analysis of clinical studies by Largent, Joan, Oefelein, Michael, Kaplan, Hilton M., Okerson, Ted, Boyle, Peter

“…Large studies suggest that the overall rate of lymphoma in women with breast implants is no greater than in the general population; clinical reports suggest an…”
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Clinical Considerations Regarding the Risks and Benefits of Textured Surface Implants and Double Capsule by Maxwell, G. Patrick, Brown, Mitchell H., Oefelein, Michael G., Kaplan, Hilton M., Hedén, Per

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Clinical trial outcomes of high- and extra high-profile breast implants by Largent, Joan A, Reisman, Neal R, Kaplan, Hilton M, Oefelein, Michael G, Jewell, Mark L

“…Clinical data concerning potential risks and benefits associated with the use of high- and extra high-profile breast implants are lacking. The authors assess…”
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Design and Fabrication of an Injection Tool for Neuromuscular Microstimulators by Kaplan, Hilton M, Loeb, Gerald E

“…The injection of small implants into precisely localized sites within the body is a difficult task usually undertaken by surgeons or interventive radiologists…”
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Safety of blind versus guided feeding tube placement: Misplacement and pneumothorax risk by Kaplan, Hilton, Curd, David

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