Search Results - "Kaplan, A. Michael"

Challenges in using the ToxRefDB as a resource for toxicity prediction modeling by Plunkett, Laura M., Kaplan, A. Michael, Becker, Richard A.

“…•Challenges were uncovered in applying ToxRefDB to a reproductive toxicity trigger.•Limitations involved interpretation of toxicity effects and designation of…”
Get full text

How well can in vitro data predict in vivo effects of chemicals? Rodent carcinogenicity as a case study by Anthony (Tony) Cox, Louis, Popken, Douglas A., Kaplan, A. Michael, Plunkett, Laura M., Becker, Richard A.

“…A recent research article by the National Center for Computational Toxicology (NCCT) (Kleinstreuer et al., 2013), indicated that high throughput screening…”
Get full text

Results of the negative control chemical allyl alcohol in the 15-day intact adult male rat screening assay for endocrine activity by O'Connor, John C., Sue Marty, M., Becker, Richard A., Snajdr, Suzanne, Michael Kaplan, A.

“…Development, standardization, and validation of methods to assess the potential of chemicals to disrupt hormonal homeostasis have been the focus of…”
Get full text

Evaluation of Tier I Screening Approaches for Detecting Endocrine-Active Compounds (EACs) by O'Connor, John C., Cook, Jon C., Marty, M. Sue, Davis, Leonard G., Kaplan, A. Michael, Carney, Edward W.

“…In 1996, Congress passed legislation requiring the U.S. Environmental Protection Agency (EPA) to implement screening testing strategies for endocrine-active…”
Get full text

An enhanced tiered toxicity testing framework with triggers for assessing hazards and risks of commodity chemicals by Plunkett, Laura M., Kaplan, A. Michael, Becker, Richard A.

“…This paper presents an enhanced integrated testing framework based on tiered testing and endpoint-specific decision triggers envisioned for application to…”
Get full text

Tiered toxicity testing: Evaluation of toxicity-based decision triggers for human health hazard characterization by Becker, Richard A., Plunkett, Laura M., Borzelleca, Joseph F., Kaplan, A. Michael

“…A set of biologically-based toxicity testing decision triggers was developed and analyzed within a tiered testing and decision-making framework for evaluating…”
Get full text

Interlaboratory Study Comparison of the 15-Day Intact Adult Male Rat Screening Assay: Evaluation of an Antithyroid Chemical and a Negative Control Chemical by Becker, Richard A., Bergfelt, Don R., Borghoff, Susan, Davis, Jeffrey P., Hamby, Bonnie T., O'Connor, John C., Kaplan, A. Michael, Sloan, Carol S., Tyl, Rochelle W., Wade, Michael, Marty, Mary Sue

“…Validation of the 15‐day intact adult male rat screening assay (IAMRSA), an endocrine activity screen, was extended beyond the 28 substances evaluated to date…”
Get full text

Mortality Among Workers Exposed to Acrylonitrile in Fiber Production: An Update by Symons, J. Morel, Kreckmann, Kim H., Sakr, Carine J., Kaplan, A. Michael, Leonard, Robin C.

“…Objective: The investigation updates the mortality experience through 2002 for a cohort of workers exposed to acrylonitrile (AN). Methods: Standardized…”
Get full text

Non-coplanar 2,2′,3,3′,4,4′,5,5′,6,6′-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities by Han, Xing, O’Connor, John C, Donner, E. Maria, Nabb, Diane L, Mingoia, Robert T, Snajdr, Suzanne I, Clarke, Jane J, Kaplan, A. Michael

“…Abstract 2,2′,3,3′,4,4′,5,5′,6,6′-Decachlorobiphenyl (PCB 209) is a fully chlorinated, non-coplanar biphenyl. To demonstrate that PCB 209 is not likely to…”
Get full text

A case study of emulation workflow: From scenario definition to route analysis in tactical wireless mobile networks by Adamson, Brian, Ta Chen, Fecko, Mariusz, Hokelek, Ibrahim, Kaplan, Michael A, Samtani, Sunil, Chintan Shah

“…In this paper 1 , we present a case study of emulation workflow in tactical wireless mobile network. The main contribution of this paper is an XML schema which…”
Get full text

Etiology of outpatient pediatric nondysenteric diarrhea: a multicenter study in the United States by CAEIRO, JUAN PABLO, MATHEWSON, JOHN J, SMITH, MELINDA A, JIANG, ZHI D, KAPLAN, MICHAEL A, DUPONT, HERBERT L

“…BACKGROUND.Few data have been published recently on the etiology of outpatient pediatric diarrhea in the US. METHODS.We determined the etiology of acute,…”
Get full text

A Multicenter Randomized Controlled Trial of a Liquid Loperamide Product Versus Placebo in the Treatment of Acute Diarrhea in Children by Kaplan, Michael A., Prior, Mary Jane, McKonly, Kimberly I., DuPont, Herbert L., Temple, Anthony R., Nelson, Edward B.

“…This randomized, double-blind, placebo-controlled trial of 48 hours' duration conducted in 13 primary care ambulatory practices in the United States and Mexico…”
Get full text

A Tandem Network of Queues with Deterministic Service and Intermediate Arrivals by Shalmon, Michael, Kaplan, Michael A

“…We present a complete analysis of delays for a tandem network of queues with deterministic service and multiple , interfering sources. The model is of a…”
Get full text

Enhancing application performance with network awareness in Tactical Networks by Ta Chen, Eswaran, S., Kaplan, M. A., Samtani, S., Shur, D., Sucec, J., Wong, L.

“…This paper presents Telcordia's Network Awareness Service (NAS), a suite of network sensing technologies that allows applications to adapt to medium-to-long…”
Get full text

Realistic wireless emulation for performance evaluation of tactical MANET protocols by Kaplan, M.A., Ta Chen, Fecko, M.A., Gurung, P., Hokelek, I., Samtani, S., Wong, L., Patel, M., Staikos, A., Greear, B.

“…Traditional approaches for testing MANET protocols and applications prior to field experimentation often involve simulation tools or small-sized physical…”
Get full text

Development of a Tier I Screening Battery for Detecting Endocrine-Active Compounds (EACs) by Cook, Jon C, Kaplan, A.Michael, Davis, Leonard G, O'connor, John C

“…One of the components of our research program is development of a mode-of-action screening battery to detect several different types of endocrine-active…”
Get full text

Urea transport in the dogfish kidney by Hays, R M, Levine, S D, Myers, J D, Heinemann, H O, Kaplan, M A, Franki, N, Berliner, H

“…There is increasing evidence that urea movement across many epithelia involves more than passive diffusion. Of particular interest is the observation that urea…”
Get more information

Loperamide-simethicone vs loperamide alone, simethicone alone, and placebo in the treatment of acute diarrhea with gas-related abdominal discomfort. A randomized controlled trial by Kaplan, M A, Prior, M J, Ash, R R, McKonly, K I, Helzner, E C, Nelson, E B

“…Acute diarrhea with gas-related abdominal discomfort is a common, usually self-limited disorder with substantial social and economic impact. To compare the…”
Get full text

Congestion awareness in tactical wireless networks: Discerning congestion-induced losses from wireless link effects by Sucec, J., Wong, L., Fecko, M. A., Kaplan, M. A., Shur, D., Samtani, S.

“…Efficient congestion detection represents an unsolved challenge for tactical networks. This paper presents an edge-based packet probing technique to detect…”
Get full text

On Redundant Multipath Operating System Support for Wireless Mesh Networks by Amir, Y., Danilov, C., Kaplan, M.A., Musaloiu-Elefteri, R., Rivera, N.

“…Low-cost wireless routers are changing the way people connect to the Internet. They are also very cheap, albeit quite limited, Linux boxes. These attributes…”
Get full text