Search Results - "Kapetanovic, Ronan"

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense by Bosch, Marta, Sánchez-Álvarez, Miguel, Fajardo, Alba, Kapetanovic, Ronan, Steiner, Bernhard, Dutra, Filipe, Moreira, Luciana, López, Juan Antonio, Campo, Rocío, Marí, Montserrat, Morales-Paytuví, Frederic, Tort, Olivia, Gubern, Albert, Templin, Rachel M, Curson, James E B, Martel, Nick, Català, Cristina, Lozano, Francisco, Tebar, Francesc, Enrich, Carlos, Vázquez, Jesús, Del Pozo, Miguel A, Sweet, Matthew J, Bozza, Patricia T, Gross, Steven P, Parton, Robert G, Pol, Albert

“…Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that…”
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Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells by Sun, Xuan, Cao, Benjamin, Naval-Sanchez, Marina, Pham, Tony, Sun, Yu Bo Yang, Williams, Brenda, Heazlewood, Shen Y., Deshpande, Nikita, Li, Jinhua, Kraus, Felix, Rae, James, Nguyen, Quan, Yari, Hamed, Schröder, Jan, Heazlewood, Chad K., Fulton, Madeline, Hatwell-Humble, Jessica, Das Gupta, Kaustav, Kapetanovic, Ronan, Chen, Xiaoli, Sweet, Matthew J., Parton, Robert G., Ryan, Michael T., Polo, Jose M., Nefzger, Christian M., Nilsson, Susan K.

“…With age, hematopoietic stem cells (HSC) undergo changes in function, including reduced regenerative potential and loss of quiescence, which is accompanied by…”
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Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion by Monteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L., Schroder, Kate

“…IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages…”
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For when bacterial infections persist: Toll‐like receptor‐inducible direct antimicrobial pathways in macrophages by Stocks, Claudia J., Schembri, Mark A., Sweet, Matthew J., Kapetanovic, Ronan

“…Macrophages are linchpins of innate immunity, responding to invading microorganisms by initiating coordinated inflammatory and antimicrobial programs…”
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The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease by Fairbairn, Lynsey, Kapetanovic, Ronan, Sester, David P., Hume, David A.

“…Review summarizes the current state of knowledge of macrophage biology in the pig, and the utility of swine as models of human disease. The biology of cells of…”
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Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages by Kapetanovic, Ronan, Afroz, Syeda Farhana, Ramnath, Divya, Lawrence, Grace MEP, Okada, Takashi, Curson, James EB, Bruin, Jost, Fairlie, David P, Schroder, Kate, St John, Justin C, Blumenthal, Antje, Sweet, Matthew J

“…Mitochondria have a multitude of functions, including energy generation and cell signaling. Recent evidence suggests that mitochondrial dynamics (i.e. the…”
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Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages by Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A., Sweet, Matthew J.

“…Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune…”
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Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper by Stafford, Sian L, Bokil, Nilesh J, Achard, Maud E S, Kapetanovic, Ronan, Schembri, Mark A, McEwan, Alastair G, Sweet, Matthew J

“…The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial…”
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Modified horseshoe crab peptides target and kill bacteria inside host cells by Amiss, Anna S., von Pein, Jessica B., Webb, Jessica R., Condon, Nicholas D., Harvey, Peta J., Phan, Minh-Duy, Schembri, Mark A., Currie, Bart J., Sweet, Matthew J., Craik, David J., Kapetanovic, Ronan, Henriques, Sónia Troeira, Lawrence, Nicole

“…Bacteria that occupy an intracellular niche can evade extracellular host immune responses and antimicrobial molecules. In addition to classic intracellular…”
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Comparative analysis of monocyte subsets in the pig by Fairbairn, Lynsey, Kapetanovic, Ronan, Beraldi, Dario, Sester, David P, Tuggle, Chris K, Archibald, Alan L, Hume, David A

“…Human and mouse monocyte can be divided into two different subpopulations based on surface marker expression: CD14/16 and Ly6C/CX3CR1, respectively. Monocyte…”
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Frontline Science: LPS‐inducible SLC30A1 drives human macrophage‐mediated zinc toxicity against intracellular Escherichia coli by Stocks, Claudia J., Pein, Jessica B., Curson, James E.B., Rae, James, Phan, Minh‐Duy, Foo, Darren, Bokil, Nilesh J., Kambe, Taiho, Peters, Kate M., Parton, Robert G., Schembri, Mark A., Kapetanovic, Ronan, Sweet, Matthew J.

“…TLR‐inducible zinc toxicity is an antimicrobial mechanism utilized by macrophages, however knowledge of molecular mechanisms mediating this response is…”
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SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages by Luo, Lin, Bokil, Nilesh J., Wall, Adam A., Kapetanovic, Ronan, Lansdaal, Natalie M., Marceline, Faustine, Burgess, Belinda J., Tong, Samuel J., Guo, Zhong, Alexandrov, Kirill, Ross, Ian L., Hibbs, Margaret L., Stow, Jennifer L., Sweet, Matthew J.

“…Danger signals activate Toll-like receptors (TLRs), thereby initiating inflammatory responses. Canonical TLR signalling, via Toll/Interleukin-1 receptor domain…”
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A gene expression atlas of the domestic pig by Freeman, Tom C, Ivens, Alasdair, Baillie, J Kenneth, Beraldi, Dario, Barnett, Mark W, Dorward, David, Downing, Alison, Fairbairn, Lynsey, Kapetanovic, Ronan, Raza, Sobia, Tomoiu, Andru, Alberio, Ramiro, Wu, Chunlei, Su, Andrew I, Summers, Kim M, Tuggle, Christopher K, Archibald, Alan L, Hume, David A

“…This work describes the first genome-wide analysis of the transcriptional landscape of the pig. A new porcine Affymetrix expression array was designed in order…”
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TLR3 drives IRF6‐dependent IL‐23p19 expression and p19/EBI3 heterodimer formation in keratinocytes by Ramnath, Divya, Tunny, Kathryn, Hohenhaus, Daniel M, Pitts, Claire M, Bergot, Anne‐Sophie, Hogarth, P Mark, Hamilton, John A, Kapetanovic, Ronan, Sturm, Richard A, Scholz, Glen M, Sweet, Matthew J

“…Interferon regulatory factor (IRF) family members impart cell‐type specificity to toll‐like receptor (TLR) signalling, and we recently identified a role for…”
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Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34 by Gow, Deborah J., Garceau, Valerie, Kapetanovic, Ronan, Sester, David P., Fici, Greg J., Shelly, John A., Wilson, Thomas L., Hume, David A.

“…► The active region of porcine CSF-1 and full length CSF-1R have been cloned. ► Biological activity of porcine CSF-1 has been demonstrated. ► The cross species…”
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Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes by Kapetanovic, Ronan, Parlato, Marianna, Fitting, Catherine, Quesniaux, Valérie, Cavaillon, Jean-Marc, Adib-Conquy, Minou

“…Mononuclear phagocytes are among the first immune cells activated after pathogens invasion. Although they all derive from the same progenitor in the bone…”
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Contribution of Phagocytosis and Intracellular Sensing for Cytokine Production by Staphylococcus aureus-Activated Macrophages by Kapetanovic, Ronan, Nahori, Marie-Anne, Balloy, Viviane, Fitting, Catherine, Philpott, Dana J, Cavaillon, Jean-Marc, Adib-Conquy, Minou

“…Toll-like receptors (TLRs) are involved in the sensing of microbially derived compounds. We analyzed the contribution of these receptors to cytokine production…”
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Prediction of altered 3'- UTR miRNA-binding sites from RNA-Seq data: the swine leukocyte antigen complex (SLA) as a model region by Endale Ahanda, Marie-Laure, Fritz, Eric R, Estellé, Jordi, Hu, Zhi-Liang, Madsen, Ole, Groenen, Martien A M, Beraldi, Dario, Kapetanovic, Ronan, Hume, David A, Rowland, Robert R R, Lunney, Joan K, Rogel-Gaillard, Claire, Reecy, James M, Giuffra, Elisabetta

“…THE SLA (swine leukocyte antigen, MHC: SLA) genes are the most important determinants of immune, infectious disease and vaccine response in pigs; several…”
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Mitochondrial dynamics: Regulating cell metabolism, homoeostasis, health and disease by Raven, Karoline D., Kapetanovic, Ronan

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Inducible antibacterial responses in macrophages by Sweet, Matthew J, Ramnath, Divya, Singhal, Amit, Kapetanovic, Ronan

“…Macrophages destroy bacteria and other microorganisms through phagocytosis-coupled antimicrobial responses, such as the generation of reactive oxygen species…”
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