Search Results - "Kapetanovic, Jasmina Cehajic"

Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR by Cehajic-Kapetanovic, Jasmina, Xue, Kanmin, Martinez-Fernandez de la Camara, Cristina, Nanda, Anika, Davies, Alexandra, Wood, Laura J., Salvetti, Anna Paola, Fischer, M. Dominik, Aylward, James W., Barnard, Alun R., Jolly, Jasleen K., Luo, Edmond, Lujan, Brandon J., Ong, Tuyen, Girach, Aniz, Black, Graeme C. M., Gregori, Ninel Z., Davis, Janet L., Rosa, Potyra R., Lotery, Andrew J., Lam, Byron L., Stanga, Paulo E., MacLaren, Robert E.

“…Retinal gene therapy has shown great promise in treating retinitis pigmentosa (RP), a primary photoreceptor degeneration that leads to severe sight loss in…”
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Flying baby optical coherence tomography alters the staging and management of advanced retinopathy of prematurity by Cehajic‐Kapetanovic, Jasmina, Xue, Kanmin, Purohit, Ravi, Patel, Chetan K.

“…Purpose To report the use of flying baby spectral domain optical coherence tomography (SD‐OCT) on infants with advanced retinopathy of prematurity (ROP), where…”
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Clinical applications of microperimetry in RPGR‐related retinitis pigmentosa: a review by Buckley, Thomas M.W., Jolly, Jasleen K., Josan, Amandeep Singh, Wood, Laura J., Cehajic‐Kapetanovic, Jasmina, MacLaren, Robert E.

“…Microperimetry, or fundus‐tracked perimetry, is a precise static‐automated perimetric technique to assess central retinal function. As visual acuity only…”
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Low-contrast visual acuity versus low-luminance visual acuity in choroideremia by Wood, Laura J, Jolly, Jasleen K, Andrews, Colm D, Wilson, Iain R, Hickey, Doron, Cehajic-Kapetanovic, Jasmina, Maclaren, Robert E

“…Choroideremia is a progressive X-linked inherited rod-cone dystrophy. Patients present with nyctalopia and progressive visual field loss, but visual acuity…”
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Molecular Strategies for RPGR Gene Therapy by Cehajic Kapetanovic, Jasmina, McClements, Michelle E, Martinez-Fernandez de la Camara, Cristina, MacLaren, Robert E

“…Mutations affecting the ( ) gene are the commonest cause of X-linked and recessive retinitis pigmentosa (RP), accounting for 10%-20% of all cases of RP. The…”
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Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances by McClements, Michelle E, Staurenghi, Federica, MacLaren, Robert E, Cehajic-Kapetanovic, Jasmina

“…The degeneration of light-detecting rod and cone photoreceptors in the human retina leads to severe visual impairment and ultimately legal blindness in…”
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Chemogenetic Activation of Melanopsin Retinal Ganglion Cells Induces Signatures of Arousal and/or Anxiety in Mice by Milosavljevic, Nina, Cehajic-Kapetanovic, Jasmina, Procyk, Christopher A., Lucas, Robert J.

“…Functional imaging and psychometric assessments indicate that bright light can enhance mood, attention, and cognitive performance in humans. Indirect evidence…”
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A distinct retinal pigment epithelial cell autofluorescence pattern in choroideremia predicts early involvement of overlying photoreceptors by Stevanovic, Marta, Cehajic Kapetanovic, Jasmina, Jolly, Jasleen K., MacLaren, Robert E.

“…Purpose Choroideremia is an X‐linked retinal disease characterized by early retinal pigment epithelium (RPE) loss and subsequent retinal degeneration. The RPE…”
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Highest reported visual acuity after electronic retinal implantation by Cehajic Kapetanovic, Jasmina, Troelenberg, Nicole, Edwards, Thomas L., Xue, Kanmin, Ramsden, James D., Stett, Alfred, Zrenner, Eberhart, MacLaren, Robert E.

“…Purpose To report the highest attained visual acuity with an electronic retinal implant for the treatment of advanced retinal degeneration following a novel…”
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Current and Future Landscape in Genetic Therapies for Leber Hereditary Optic Neuropathy by Shamsnajafabadi, Hoda, MacLaren, Robert E, Cehajic-Kapetanovic, Jasmina

“…Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial genetic disease that causes blindness in young adults. Over 50 inherited…”
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Gene-agnostic therapeutic approaches for inherited retinal degenerations by John, Molly C, Quinn, Joel, Hu, Monica L, Cehajic-Kapetanovic, Jasmina, Xue, Kanmin

“…Inherited retinal diseases (IRDs) are associated with mutations in over 250 genes and represent a major cause of irreversible blindness worldwide. While gene…”
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Molecular Therapies for Choroideremia by Cehajic Kapetanovic, Jasmina, Barnard, Alun R, MacLaren, Robert E

“…Advances in molecular research have culminated in the development of novel gene-based therapies for inherited retinal diseases. We have recently witnessed…”
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AAV Induced Expression of Human Rod and Cone Opsin in Bipolar Cells of a Mouse Model of Retinal Degeneration by McClements, Michelle E., Staurenghi, Federica, Visel, Meike, Flannery, John G., MacLaren, Robert E., Cehajic-Kapetanovic, Jasmina

“…Vision loss caused by inherited retinal degeneration affects millions of people worldwide, and clinical trials involving gene supplementation strategies are…”
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Age-related macular degeneration: suitability of optogenetic therapy for geographic atrophy by Borchert, Grace A, Shamsnajafabadi, Hoda, Ng, Benjamin W J, Xue, Kanmin, De Silva, Samantha R, Downes, Susan M, MacLaren, Robert E, Cehajic-Kapetanovic, Jasmina

“…Age-related macular degeneration (AMD) is a growing public health concern given the aging population and it is the leading cause of blindness in developed…”
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The Role of Inflammation in Age-Related Macular Degeneration-Therapeutic Landscapes in Geographic Atrophy by Borchert, Grace A, Shamsnajafabadi, Hoda, Hu, Monica L, De Silva, Samantha R, Downes, Susan M, MacLaren, Robert E, Xue, Kanmin, Cehajic-Kapetanovic, Jasmina

“…Age-related macular degeneration (AMD) is the leading cause of vision loss and visual impairment in people over 50 years of age. In the current therapeutic…”
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Gene therapy for choroideremia using an adeno-associated viral vector encoding Rab escort protein 1: the REGENERATE open-label trial by Cehajic-Kapetanovic, Jasmina, Bellini, Marco P, Taylor, Laura J, Yusuf, Imran H, Soomro, Taha, da Cruz, Lyndon, MacLaren, Robert E

“…Background Choroideremia is an X-linked inherited retinal degeneration that begins in childhood with nyctalopia and loss of peripheral vision, and gradually…”
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Outcomes and Adverse Effects of Voretigene Neparvovec Treatment for Biallelic RPE65 -Mediated Inherited Retinal Dystrophies in a Cohort of Patients from a Single Center by Kiraly, Peter, Cottriall, Charles L, Taylor, Laura J, Jolly, Jasleen K, Cehajic-Kapetanovic, Jasmina, Yusuf, Imran H, Martinez-Fernandez de la Camara, Cristina, Shanks, Morag, Downes, Susan M, MacLaren, Robert E, Fischer, M Dominik

“…Our study evaluated the morphological and functional outcomes, and the side effects, of voretigene neparvovec (VN) gene therapy for RPE65-mediated inherited…”
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Compound dominant-null heterozygosity in a family with RP1-related retinal dystrophy by Buckley, Thomas M.W., Cehajic-Kapetanovic, Jasmina, Shanks, Morag, Clouston, Penny, MacLaren, Robert E.

“…To report on the presence of autosomal dominant and compound dominant-null RP1-related retinitis pigmentosa in the same non-consanguineous family. The father…”
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Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice by Cehajic-Kapetanovic, Jasmina, Milosavljevic, Nina, Bedford, Robert A, Lucas, Robert J, Bishop, Paul N

“…Viral gene delivery is showing great promise for treating retinal disease. Although subretinal vector delivery has mainly been used to date, intravitreal…”
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Enhancement of light sensitivity in retinal degeneration in mice by use of novel optogenetic approaches by Cehajic-Kapetanovic, Jasmina, Dr, Bishop, Paul, Prof, Lucas, Robert, Prof

“…Abstract Background Inherited retinal degenerations (including retinitis pigmentosa) that lead to irreversible blindness due to progressive loss of rods and…”
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