Induced in vivo targeted transarterial and transvenous immunostimulation in patients with unresectable pancreatic carcinoma

On the basis of the preliminary results of this study, in vivo dual immunostimulation in patients with advanced pancreatic cancer appears to be a promising therapeutic alternative. A surgical technique is presented in which the spleen of the patient is used as the target organ for in vivo lymphokine...

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Bibliographic Details
Published in:	Hepato-gastroenterology Vol. 40; no. 6; p. 574
Main Authors:	Lygidakis, N J, Savanis, G, Toloupakis, E, Katsikoyiannis, N, Kapenanakis, A, Pothoulakis, J, Maganas, D, Papadimitriou, A, Batziotis, N, Zisimopoulos, A
Format:	Journal Article
Language:	English
Published:	Greece 01-12-1993
Subjects:	Aged Catheterization - methods Catheters, Indwelling Drug Delivery Systems Female Humans Immunotherapy, Adoptive - methods Interferon-gamma - administration & dosage Interferon-gamma - therapeutic use Interleukin-2 - administration & dosage Interleukin-2 - therapeutic use Male Middle Aged Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - therapy Spleen - immunology Splenic Artery Splenic Vein Tomography, X-Ray Computed
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Summary:	On the basis of the preliminary results of this study, in vivo dual immunostimulation in patients with advanced pancreatic cancer appears to be a promising therapeutic alternative. A surgical technique is presented in which the spleen of the patient is used as the target organ for in vivo lymphokine activated killer cell generation. Additionally, applying locoregional transvenous administration of gamma-INF and IL2 in the area of the tumor, tumor infiltrating lymphocytes (TIL) area activated, thus completing the system of dual in vivo immunostimulation.
ISSN:	0172-6390