Reversible effects of mercuric chloride on reproductive organs of the male mouse

Effects of oral administration of mercuric chloride (HgCl2,1.25 mg/kg) daily for 30 d on the mouse testis, vas deferens, epididymis, and cauda epididymal sperm were investigated. Testis, vas deferens, and epididymis functions were evaluated with respect to sperm count, motility, and viability, and b...

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Bibliographic Details
Published in:	Reproductive toxicology (Elmsford, N.Y.) Vol. 10; no. 2; pp. 153 - 159
Main Authors:	Sharma, Arti K., Kapadia, Amita G., Fransis, Peter, Rao, Mandava V.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-03-1996 Elsevier
Subjects:	Animals Biological and medical sciences Body Weight - drug effects Cell Nucleus - drug effects Cell Nucleus - pathology Chemical and industrial products toxicology. Toxic occupational diseases Copulation epididymis Genitalia, Male - drug effects Genitalia, Male - pathology Male Medical sciences mercuric chloride Mercuric Chloride - toxicity Metals and various inorganic compounds Mice Organ Size - drug effects reversibility Sperm Count - drug effects Sperm Motility - drug effects Spermatozoa - drug effects Spermatozoa - pathology testis Testosterone - blood toxicity Toxicology vas deferens toxicity mercuric chloride vas deferens epididymis reversibility testis mice Reproduction diseases Toxicity Rodentia Oral administration Testicle Vas deferens Heavy metal Vertebrata Epididymis Mammalia Mouse Mercury II Chlorides Animal Reversibility Male genital diseases
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Summary:	Effects of oral administration of mercuric chloride (HgCl2,1.25 mg/kg) daily for 30 d on the mouse testis, vas deferens, epididymis, and cauda epididymal sperm were investigated. Testis, vas deferens, and epididymis functions were evaluated with respect to sperm count, motility, and viability, and biochemical tests, including succinate dehydrogenase (SDH), adenosine triphosphatase, sialic acid, protein, cholesterol, and glycogen levels in these tissue. Sperm morphology and sperm nuclear integrity were evaluated with standard staining methods. Treatment did not affect whole body and tissue weights. Sperm parameters and fertility were reduced by HgCl2 and most of the biochemical parameters declined. Morphologic histologie alterations were also observed in the tissues studied. All parameters partially recovered after withdrawal of HgCl2 for 45 d.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0890-6238 1873-1708
DOI:	10.1016/0890-6238(95)02058-6