Search Results - "Kap, Yolanda S"

EBV Infection and Multiple Sclerosis: Lessons from a Marmoset Model by tHart, Bert A, Kap, Yolanda S, Morandi, Elena, Laman, Jon D, Gran, Bruno

“…Multiple sclerosis (MS) is thought to be initiated by the interaction of genetic and environmental factors, eliciting an autoimmune attack on the central…”
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Targeted Diet Modification Reduces Multiple Sclerosis-like Disease in Adult Marmoset Monkeys from an Outbred Colony by Kap, Yolanda S, Bus-Spoor, Carien, van Driel, Nikki, Dubbelaar, Marissa L, Grit, Corien, Kooistra, Susanne M, Fagrouch, Zahra C, Verschoor, Ernst J, Bauer, Jan, Eggen, Bart J L, Harmsen, Hermie J M, Laman, Jon D, 't Hart, Bert A

“…Experimental autoimmune encephalomyelitis (EAE) in common marmosets is a translationally relevant model of the chronic neurologic disease multiple sclerosis…”
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Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey by Dunham, Jordon, van de Vis, Reinofke, Bauer, Jan, Wubben, Jacqueline, van Driel, Nikki, Laman, Jon D, 't Hart, Bert A, Kap, Yolanda S

“…Oxidative stress is increasingly implicated as a co-factor of tissue injury in inflammatory/demyelinating disorders of the central nervous system (CNS), such…”
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A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge by Koopman, Gerrit, Amacker, Mario, Stegmann, Toon, Verschoor, Ernst J., Verstrepen, Babs E., Bhoelan, Farien, Bemelman, Denzel, Böszörményi, Kinga P., Fagrouch, Zahra, Kiemenyi-Kayere, Gwendoline, Mortier, Daniella, Verel, Dagmar E., Niphuis, Henk, Acar, Roja Fidel, Kondova, Ivanela, Kap, Yolanda S., Bogers, Willy M. J. M., Mooij, Petra, Fleury, Sylvain

“…Influenza virosomes serve as antigen delivery vehicles and pre-existing immunity toward influenza improves the immune responses toward antigens. Here, vaccine…”
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Oxidative Injury and Iron Redistribution Are Pathological Hallmarks of Marmoset Experimental Autoimmune Encephalomyelitis by Dunham, Jordon, Bauer, Jan, Campbell, Graham R, Mahad, Don J, van Driel, Nikki, van der Pol, Susanne M A, ‘t Hart, Bert A, Lassmann, Hans, Laman, Jon D, van Horssen, Jack, Kap, Yolanda S

“…Oxidative damage and iron redistribution are associated with the pathogenesis and progression of multiple sclerosis (MS), but these aspects are not entirely…”
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A B Cell-Driven Autoimmune Pathway Leading to Pathological Hallmarks of Progressive Multiple Sclerosis in the Marmoset Experimental Autoimmune Encephalomyelitis Model by 't Hart, Bert A, Dunham, Jordon, Faber, Bart W, Laman, Jon D, van Horssen, Jack, Bauer, Jan, Kap, Yolanda S

“…The absence of pathological hallmarks of progressive multiple sclerosis (MS) in commonly used rodent models of experimental autoimmune encephalomyelitis (EAE)…”
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Tracing from Fat Tissue, Liver, and Pancreas: A Neuroanatomical Framework for the Role of the Brain in Type 2 Diabetes by Kreier, Felix, Kap, Yolanda S, Mettenleiter, Thomas C, van Heijningen, Caroline, van der Vliet, Jan, Kalsbeek, Andries, Sauerwein, Hans P, Fliers, Eric, Romijn, Johannes A, Buijs, Ruud M

“…The hypothalamus uses hormones and the autonomic nervous system to balance energy fluxes in the body. Here we show that the autonomic nervous system has a…”
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An Overview of Models, Methods, and Reagents Developed for Translational Autoimmunity Research in the Common Marmoset (Callithrix jacchus) by Jagessar, S. Anwar, Vierboom, Michel, Blezer, Erwin L.A., Bauer, Jan, Hart, Bert A. ‘t, Kap, Yolanda S.

“…The common marmoset (Callithrix jacchus) is a small-bodied Neotropical primate and a useful preclinical animal model for translational research into…”
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Experimental Autoimmune Encephalomyelitis in the Common Marmoset, a Bridge Between Rodent EAE and Multiple Sclerosis for Immunotherapy Development by Kap, Yolanda S., Laman, Jon D., ‘t Hart, Bert A.

“…The attrition rate of new drugs for central nervous system diseases including multiple sclerosis (MS) is very high. A widely recognized bottleneck in the…”
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Synthetic Human Chorionic Gonadotropin–Related Oligopeptides Impair Early Innate Immune Responses to Listeria monocytogenes in Mice by van der Zee, Marten, Dik, William A., Kap, Yolanda S., Dillon, Marilyn J., Benner, Robbert, Leenen, Pieter J. M., Khan, Nisar A., Drevets, Douglas A.

“…Background. Synthetic human chorionic gonadotropin (hCG)–related oligopeptides are potent inhibitors of pathogenic inflammatory responses induced by in vivo…”
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A Monoclonal Antibody Selection for Immunohistochemical Examination of Lymphoid Tissues From Non-human Primates by Kap, Yolanda S, van Meurs, Marjan, van Driel, Nikki, Koopman, Gerrit, Melief, Marie-Jose, Brok, Herbert P.M, Laman, Jon D, t Hart, Bert A

“…Non-human primates (NHPs) offer valuable animal models for basic research into human diseases and for the preclinical validation of new therapeutics. Detailed…”
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Reverse Translation for Assessment of Confidence in Animal Models of Multiple Sclerosis for Drug Discovery by 't Hart, Bert A., Laman, Jon D., Kap, Yolanda S.

“…The poor predictive quality of currently used animal models in preclinical research is an important cause of the high attrition of promising drug candidates…”
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Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis by Licht-Mayer, Simon, Campbell, Graham R., Canizares, Marco, Mehta, Arpan R., Gane, Angus B., McGill, Katie, Ghosh, Aniket, Fullerton, Alexander, Menezes, Niels, Dean, Jasmine, Dunham, Jordon, Al-Azki, Sarah, Pryce, Gareth, Zandee, Stephanie, Zhao, Chao, Kipp, Markus, Smith, Kenneth J., Baker, David, Altmann, Daniel, Anderton, Stephen M., Kap, Yolanda S., Laman, Jon D., Hart, Bert A.‘t, Rodriguez, Moses, Watzlawick, Ralf, Schwab, Jan M., Carter, Roderick, Morton, Nicholas, Zagnoni, Michele, Franklin, Robin J. M., Mitchell, Rory, Fleetwood-Walker, Sue, Lyons, David A., Chandran, Siddharthan, Lassmann, Hans, Trapp, Bruce D., Mahad, Don J.

“…Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the…”
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The common marmoset as an indispensable animal model for immunotherapy development in multiple sclerosis by Kap, Yolanda S., Jagessar, S. Anwar, Dunham, Jordon, ‘t Hart, Bert A.

“…•We developed a valid preclinical model for chronic MS in marmosets.•The model displays pathological aspects of progressive MS in cortical grey matter.•The…”
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Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis by Licht‐Mayer, Simon, Campbell, Graham R., Mehta, Arpan R., McGill, Katie, Symonds, Alex, Al‐Azki, Sarah, Pryce, Gareth, Zandee, Stephanie, Zhao, Chao, Kipp, Markus, Smith, Kenneth J., Baker, David, Altmann, Daniel, Anderton, Stephen M., Kap, Yolanda S., Laman, Jon D., 't Hart, Bert A., Rodriguez, Moses, Franklin, Robin J. M., Chandran, Siddharthan, Lassmann, Hans, Trapp, Bruce D., Mahad, Don J.

“…Aims Axonal injury in multiple sclerosis (MS) and experimental models is most frequently detected in acutely demyelinating lesions. We recently reported a…”
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CD20+ B cell depletion alters T cell homing by Kap, Yolanda S, van Driel, Nikki, Laman, Jon D, Tak, Paul P, 't Hart, Bert A

“…Depleting mAbs against the pan B cell marker CD20 are remarkably effective in the treatment of autoimmune-mediated inflammatory disorders, but the underlying…”
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Experimental Autoimmune Encephalomyelitis in Marmosets by Jagessar, S Anwar, Dijkman, Karin, Dunham, Jordon, 't Hart, Bert A, Kap, Yolanda S

“…Experimental autoimmune encephalomyelitis (EAE) in the common marmoset, a small-bodied Neotropical primate, is a well-known and validated animal model for…”
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Induction of Progressive Demyelinating Autoimmune Encephalomyelitis in Common Marmoset Monkeys Using MOG34-56 Peptide in Incomplete Freund Adjuvant by Jagessar, S. Anwar, Kap, Yolanda S, Heijmans, Nicole, van Driel, Nikki, van Straalen, Linda, Bajramovic, Jeffrey J, Brok, Herbert P.M, Blezer, Erwin L.A, Bauer, Jan, Laman, Jon D, 't Hart, Bert A

“…Experimental autoimmune encephalomyelitis in the neotropical primate common marmoset (Callithrix jacchus) is a relevant autoimmune animal model of multiple…”
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Late B cell depletion with a human anti-human CD20 IgG1κ monoclonal antibody halts the development of experimental autoimmune encephalomyelitis in marmosets by Kap, Yolanda S, van Driel, Nikki, Blezer, Erwin, Parren, Paul W H I, Bleeker, Wim K, Laman, Jon D, Craigen, Jenny L, 't Hart, Bert A

“…Depletion of CD20(+) B cells has been related to reduced clinical activity in relapsing-remitting multiple sclerosis. The underlying mechanism is not…”
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Improvement of preclinical animal models for autoimmune-mediated disorders via reverse translation of failed therapies by ‘t Hart, Bert A., Jagessar, S. Anwar, Kap, Yolanda S., Haanstra, Krista G., Philippens, Ingrid H.C.H.M., Serguera, Che, Langermans, Jan, Vierboom, Michel

“…•The high attrition of new therapies for AIMID calls for action.•The cause is the poor translation from inbred/SPF mice models to the patient.•Microbially…”
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