Search Results - "Kaoru Toyoda"

Spontaneous histiocytic sarcoma originating from the epididymis in a CD-1 mouse by Shimazaki, Taishi, Yasui, Yuzo, Anagawa-Nakamura, Akiko, Toyoda, Kaoru, Yamazaki, Ryo, Onami, Saeko, Kemmochi, Yusuke, Shoda, Toshiyuki

“…We report a histiocytic sarcoma originating from the epididymis observed in a 110-week-old male CD-1 mouse in a carcinogenicity study. At necropsy, no lesions…”
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Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats by Kondo, Kazuma, Yamada, Naohito, Suzuki, Yusuke, Hashimoto, Tatsuji, Toyoda, Kaoru, Takahashi, Tadakazu, Kobayashi, Akio, Sugai, Shoichiro, Yoshinari, Kouichi

“…Some patients encounter hepatotoxicity after repeated acetaminophen (APAP) dosing even at therapeutic doses. In the present study, we focused on the diabetic…”
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High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats by Toyoda, Kaoru, Suzuki, Yusuke, Muta, Kyotaka, Masuyama, Taku, Kakimoto, Kochi, Kobayashi, Akio, Shoda, Toshiyuki, Sugai, Shoichiro

“…Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple…”
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Pressure loss prediction of gaseous flow in a conduit-system of microchannel heat exchanger by Shintaro MURAKAMI, Kaoru TOYODA, Yutaka ASAKO

“…Three methods for predicting pressure loss of gaseous flow in a conduit-system of microchannel heat exchanger are proposed and discussed. In the experiment,…”
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Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-Leprfa (SDT fatty) rats by Takahashi, Tadakazu, Matsuura, Chizuru, Toyoda, Kaoru, Suzuki, Yusuke, Yamada, Naohito, Kobayashi, Akio, Sugai, Shoichiro, Shimoi, Kayoko

“…In order to estimate the potential risk of chemicals including drug in patients with type 2 diabetes mellitus (T2DM), we investigated allyl alcohol induced…”
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Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats by Kemmochi, Yusuke, Ohta, Takeshi, Motohashi, Yu, Kaneshige, Akihiro, Katsumi, Sohei, Kakimoto, Kochi, Yasui, Yuzo, Anagawa-Nakamura, Akiko, Toyoda, Kaoru, Taniai-Riya, Eriko, Takahashi, Akemi, Shoda, Toshiyuki, Yamada, Takahisa

“…Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the…”
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Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model by SUZUKI, YUSUKE, KONDO, KAZUMA, TOYODA, KAORU, TANAKA, YUKI, KOBAYASHI, AKIO, YOKOYAMA, DAIGO, SAKAKIBARA, HIROYUKI

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Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin by KATSUDA, Yoshiaki, SASASE, Tomohiko, TADAKI, Hironobu, MERA, Yasuko, MOTOHASHI, Yu, Kemmochi, Yusuke, TOYODA, Kaoru, KAKIMOTO, Kochi, KUME, Shinichi, OHTA, Takeshi

“…The spontaneously diabetic torii (SDT) fatty rat is a new model of type 2 diabetes showing overt obesity, hyperglycemia and hyperlipidemia. With early onset of…”
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Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat by Taniai-Riya, Eriko, Miyajima, Katsuhiro, Kakimoto, Kochi, Ohta, Takeshi, Yasui, Yuzo, Kemmochi, Yusuke, Anagawa-Nakamura, Akiko, Toyoda, Kaoru, Takahashi, Akemi, Shoda, Toshiyuki

“…The Spontaneously Diabetic Torii (SDT) rat is a rat model of nonobese type 2 diabetes mellitus, and hepatocellular adenomas have not been reported in this…”
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Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients by Kondo, Kazuma, Yamada, Naohito, Suzuki, Yusuke, Toyoda, Kaoru, Hashimoto, Tatsuji, Takahashi, Akemi, Kobayashi, Akio, Shoda, Toshiyuki, Kuno, Hideyuki, Sugai, Shoichiro

“…Acetaminophen (APAP) is a commonly used and effective analgesic and antipyretic agent. However, some patients encounter hepatotoxicity after repeated APAP…”
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Ocular Inflammation in Uveal Tract in Aged Obese Type 2 Diabetic Rats (Spontaneously Diabetic Torii Fatty Rats) by Kakehashi, Akihiro, Shoda, Toshiyuki, Toyoda, Kaoru, Yasui, Yuzo, Sasase, Tomohiko, Ohta, Takeshi, Miyajima, Katsuhiro, Kemmochi, Yusuke, Kakimoto, Kochi

“…We report uveitis observed in an obese type 2 diabetes rat model, Spontaneously Diabetic Torii Leprfa (SDT fatty) rats aged over 50 weeks. The eyes of SDT…”
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Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats by Yusuke Kemmochi, Takeshi Ohta, Yu Motohashi, Akihiro Kaneshige, Sohei Katsumi, Kochi Kakimoto, Yuzo Yasui, Akiko Anagawa-Nakamura, Kaoru Toyoda, Eriko Taniai-Riya, Akemi Takahashi, Toshiyuki Shoda, Takahisa Yamada

“…[Abstract] : Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia,…”
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Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat by Eriko Taniai-Riya, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta, Yuzo Yasui, Yusuke Kemmochi, Akiko Anagawa-Nakamura, Kaoru Toyoda, Akemi Takahashi, Toshiyuki Shoda

“…[Abstract]: The Spontaneously Diabetic Torii (SDT) rat is a rat model of nonobese type 2 diabetes mellitus, and hepatocellular adenomas have not been reported…”
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Evaluation of the Carcinogenic Potential of Enarodustat (JTZ-951), a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor, in 26-Week Tg.rasH2 Mouse Study and 2-Year Sprague-Dawley Rat Study by Kemmochi, Yusuke, Toyoda, Kaoru, Ishida, Tomio, Yasui, Yuzo, Shoda, Toshiyuki

“…Enarodustat (JTZ-951) is an oral hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor for the treatment of anemia with chronic kidney disease…”
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Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model by Suzuki, Yusuke, Kondo, Kazuma, Toyoda, Kaoru, Tanaka, Yuki, Kobayashi, Akio, Yokoyama, Daigo, Sakakibara, Hiroyuki

“…The habitual consumption of excessive fructose is associated with the onset and progression of lifestyle-related diseases, such as nonalcoholic fatty liver…”
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A novel JAK inhibitor JTE‐052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents by Tanimoto, Atsuo, Shinozaki, Yuichi, Yamamoto, Yasuo, Katsuda, Yoshiaki, Taniai‐Riya, Eriko, Toyoda, Kaoru, Kakimoto, Kochi, Kimoto, Yukari, Amano, Wataru, Konishi, Noriko, Hayashi, Mikio

“…Janus kinases (JAKs) are required for several inflammatory cytokine signalling pathways and are implicated in the pathogenesis of chronic dermatitis, including…”
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Spontaneous histiocytic sarcoma originating from the epididymis in a CD-1 mouse by SHIMAZAKI, Taishi, YASUI, Yuzo, ANAGAWA-NAKAMURA, Akiko, TOYODA, Kaoru, YAMAZAKI, Ryo, ONAMI, Saeko, KEMMOCHI, Yusuke, SHODA, Toshiyuki

“…We report a histiocytic sarcoma originating from the epididymis observed in a 110-week-old male CD-1 mouse in a carcinogenicity study. At necropsy, no lesions…”
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Unilateral nephrectomized SHR/NDmcr-cp rat shows a progressive decline of glomerular filtration with tubular interstitial lesions by Shinozaki, Y, Fukui, K, Maekawa, M, Toyoda, K, Yoshiuchi, H, Inagaki, K, Uno, K, Miyajima, K, Ohta, T

“…In patients with diabetic kidney disease (DKD), the estimated glomerular filtration rate (eGFR) or creatinine clearance rate (Ccr) is always used as an index…”
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Pathophysiological analysis of uninephrectomized db/db mice as a model of severe diabetic kidney disease by Maekawa, M, Maekawa, T, Sasase, T, Takagi, K, Takeuchi, S, Kitamoto, M, Nakagawa, T, Toyoda, K, Konishi, N, Ohta, T, Yamada, T

“…Diabetic nephropathy, included in diabetic kidney disease (DKD), is the primary disease leading to end-stage renal disease (ESRD) or dialysis treatment,…”
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Immunohistochemical Characterization of Spontaneous Sertoli Cell Clusters in the Seminiferous Tubules of C57BL/6J Mice by Anagawa-Nakamura, Akiko, Kakimoto, Kochi, Miyajima, Katsuhiro, Yasui, Yuzo, Kemmochi, Yusuke, Toyoda, Kaoru, Taniai, Eriko, Takahashi, Akemi, Shoda, Toshiyuki

“…Cell clusters were observed in the seminiferous tubules of C57BL/6J mice as a spontaneous lesion in a 2-week toxicity study, and they were demonstrated to be…”
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