Search Results - "Kaoma, Tony"

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures by Sousa, Carole, Golebiewska, Anna, Poovathingal, Suresh K, Kaoma, Tony, Pires‐Afonso, Yolanda, Martina, Silvia, Coowar, Djalil, Azuaje, Francisco, Skupin, Alexander, Balling, Rudi, Biber, Knut, Niclou, Simone P, Michelucci, Alessandro

“…Microglia are specialized parenchymal‐resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural…”
Get full text

Assessing cellular and circulating miRNA recovery: the impact of the RNA isolation method and the quantity of input material by El-Khoury, Victoria, Pierson, Sandrine, Kaoma, Tony, Bernardin, François, Berchem, Guy

“…MicroRNAs (miRNAs) have emerged as promising cancer biomarkers. However, exploiting their informative potential requires careful optimization of their…”
Get full text

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas by Zeiner, Pia S., Preusse, Corinna, Golebiewska, Anna, Zinke, Jenny, Iriondo, Ane, Muller, Arnaud, Kaoma, Tony, Filipski, Katharina, Müller‐Eschner, Monika, Bernatz, Simon, Blank, Anna‐Eva, Baumgarten, Peter, Ilina, Elena, Grote, Anne, Hansmann, Martin L., Verhoff, Marcel A., Franz, Kea, Feuerhake, Friedrich, Steinbach, Joachim P., Wischhusen, Jörg, Stenzel, Werner, Niclou, Simone P., Harter, Patrick N., Mittelbronn, Michel

“…While the central nervous system is considered an immunoprivileged site and brain tumors display immunosuppressive features, both innate and adaptive immune…”
Get full text

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology by Golebiewska, Anna, Hau, Ann-Christin, Oudin, Anaïs, Stieber, Daniel, Yabo, Yahaya A., Baus, Virginie, Barthelemy, Vanessa, Klein, Eliane, Bougnaud, Sébastien, Keunen, Olivier, Wantz, May, Michelucci, Alessandro, Neirinckx, Virginie, Muller, Arnaud, Kaoma, Tony, Nazarov, Petr V., Azuaje, Francisco, De Falco, Alfonso, Flies, Ben, Richart, Lorraine, Poovathingal, Suresh, Arns, Thais, Grzyb, Kamil, Mock, Andreas, Herold-Mende, Christel, Steino, Anne, Brown, Dennis, May, Patrick, Miletic, Hrvoje, Malta, Tathiane M., Noushmehr, Houtan, Kwon, Yong-Jun, Jahn, Winnie, Klink, Barbara, Tanner, Georgette, Stead, Lucy F., Mittelbronn, Michel, Skupin, Alexander, Hertel, Frank, Bjerkvig, Rolf, Niclou, Simone P.

“…Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the…”
Get full text

Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma by Sanzey, Morgane, Abdul Rahim, Siti Aminah, Oudin, Anais, Dirkse, Anne, Kaoma, Tony, Vallar, Laurent, Herold-Mende, Christel, Bjerkvig, Rolf, Golebiewska, Anna, Niclou, Simone P

“…Major efforts have been put in anti-angiogenic treatment for glioblastoma (GBM), an aggressive and highly vascularized brain tumor with dismal prognosis…”
Get full text

Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas by Zhang, Lu, Fritah, Sabrina, Nazarov, Petr V, Kaoma, Tony, Van Dyck, Eric

“…By generating protein diversity, alternative splicing provides an important oncogenic pathway. Isocitrate dehydrogenase ( ) 1 and 2 mutations and 1p/19q…”
Get full text

RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples by Nazarov, Petr V, Muller, Arnaud, Kaoma, Tony, Nicot, Nathalie, Maximo, Cristina, Birembaut, Philippe, Tran, Nhan L, Dittmar, Gunnar, Vallar, Laurent

“…RNA sequencing (RNA-seq) and microarrays are two transcriptomics techniques aimed at the quantification of transcribed genes and their isoforms. Here we…”
Get full text

Reference-free deconvolution, visualization and interpretation of complex DNA methylation data using DecompPipeline, MeDeCom and FactorViz by Scherer, Michael, Nazarov, Petr V., Toth, Reka, Sahay, Shashwat, Kaoma, Tony, Maurer, Valentin, Vedeneev, Nikita, Plass, Christoph, Lengauer, Thomas, Walter, Jörn, Lutsik, Pavlo

“…DNA methylation profiling offers unique insights into human development and diseases. Often the analysis of complex tissues and cell mixtures is the only…”
Get full text

Neurodegeneration and neuroinflammation are linked, but independent of alpha‐synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease by Garcia, Pierre, Jürgens‐Wemheuer, Wiebke, Uriarte Huarte, Oihane, Michelucci, Alessandro, Masuch, Annette, Brioschi, Simone, Weihofen, Andreas, Koncina, Eric, Coowar, Djalil, Heurtaux, Tony, Glaab, Enrico, Balling, Rudi, Sousa, Carole, Kaoma, Tony, Nicot, Nathalie, Pfander, Tatjana, Schulz‐Schaeffer, Walter, Allouche, Ahmad, Fischer, Nicolas, Biber, Knut, Kleine‐Borgmann, Felix, Mittelbronn, Michel, Ostaszewski, Marek, Schmit, Kristopher J., Buttini, Manuel

“…A key pathological process in Parkinson's disease (PD) is the transneuronal spreading of α‐synuclein. Alpha‐synuclein (α‐syn) is a presynaptic protein that, in…”
Get full text

Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells by Larrue, Clément, Guiraud, Nathan, Mouchel, Pierre-Luc, Dubois, Marine, Farge, Thomas, Gotanègre, Mathilde, Bosc, Claudie, Saland, Estelle, Nicolau-Travers, Marie-Laure, Sabatier, Marie, Serhan, Nizar, Sahal, Ambrine, Boet, Emeline, Mouche, Sarah, Heydt, Quentin, Aroua, Nesrine, Stuani, Lucille, Kaoma, Tony, Angenendt, Linus, Mikesch, Jan-Henrik, Schliemann, Christoph, Vergez, François, Tamburini, Jérôme, Récher, Christian, Sarry, Jean-Emmanuel

“…Drug tolerant/resistant leukemic stem cell (LSC) subpopulations may explain frequent relapses in acute myeloid leukemia (AML), suggesting that these…”
Get full text

Machine learning-assisted neurotoxicity prediction in human midbrain organoids by Monzel, Anna S., Hemmer, Kathrin, Kaoma, Tony, Smits, Lisa M., Bolognin, Silvia, Lucarelli, Philippe, Rosety, Isabel, Zagare, Alise, Antony, Paul, Nickels, Sarah L., Krueger, Rejko, Azuaje, Francisco, Schwamborn, Jens C.

“…Brain organoids are highly complex multi-cellular tissue proxies, which have recently risen as novel tools to study neurodegenerative diseases such as…”
Get full text

Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles by Merz, Myriam P., Seal, Snehaa V., Grova, Nathalie, Mériaux, Sophie, Guebels, Pauline, Kanli, Georgia, Mommaerts, Elise, Nicot, Nathalie, Kaoma, Tony, Keunen, Olivier, Nazarov, Petr V., Turner, Jonathan D.

“…Early-life adversity covers a range of physical, social and environmental stressors. Acute viral infections in early life are a major source of such adversity…”
Get full text

A New Synuclein-Transgenic Mouse Model for Early Parkinson’s Reveals Molecular Features of Preclinical Disease by Hendrickx, Diana M., Garcia, Pierre, Ashrafi, Amer, Sciortino, Alessia, Schmit, Kristopher J., Kollmus, Heike, Nicot, Nathalie, Kaoma, Tony, Vallar, Laurent, Buttini, Manuel, Glaab, Enrico

“…Understanding Parkinson’s disease (PD), in particular in its earliest phases, is important for diagnosis and treatment. However, human brain samples are…”
Get full text

The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray by Moussay, Etienne, Kaoma, Tony, Baginska, Joanna, Muller, Arnaud, Van Moer, Kris, Nicot, Nathalie, Nazarov, Petr V., Vallar, Laurent, Chouaib, Salem, Berchem, Guy, Janji, Bassam

“…While the autophagic process is mainly regulated at the post-translational level, a growing body of evidence suggests that autophagy might also be regulated at…”
Get full text

PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation by Lind-Holm Mogensen, Frida, Sousa, Carole, Ameli, Corrado, Badanjak, Katja, Pereira, Sandro L, Muller, Arnaud, Kaoma, Tony, Coowar, Djalil, Scafidi, Andrea, Poovathingal, Suresh K, Tziortziou, Maria, Antony, Paul M A, Nicot, Nathalie, Ginolhac, Aurélien, Vogt Weisenhorn, Daniela M, Wurst, Wolfgang, Poli, Aurélie, Nazarov, Petr V, Skupin, Alexander, Grünewald, Anne, Michelucci, Alessandro

“…Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson's disease (PD)…”
Get full text

The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs by Bossis, Guillaume, Sarry, Jean-Emmanuel, Kifagi, Chamseddine, Ristic, Marko, Saland, Estelle, Vergez, François, Salem, Tamara, Boutzen, Héléna, Baik, Hayeon, Brockly, Frédérique, Pelegrin, Mireia, Kaoma, Tony, Vallar, Laurent, Récher, Christian, Manenti, Stéphane, Piechaczyk, Marc

“…Chemotherapeutic drugs used in the treatment of acute myeloid leukemias (AMLs) are thought to induce cancer cell death through the generation of DNA…”
Get full text

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts by Yabo, Yahaya A, Moreno-Sanchez, Pilar M, Pires-Afonso, Yolanda, Kaoma, Tony, Nosirov, Bakhtiyor, Scafidi, Andrea, Ermini, Luca, Lipsa, Anuja, Oudin, Anaïs, Kyriakis, Dimitrios, Grzyb, Kamil, Poovathingal, Suresh K, Poli, Aurélie, Muller, Arnaud, Toth, Reka, Klink, Barbara, Berchem, Guy, Berthold, Christophe, Hertel, Frank, Mittelbronn, Michel, Heiland, Dieter H, Skupin, Alexander, Nazarov, Petr V, Niclou, Simone P, Michelucci, Alessandro, Golebiewska, Anna

“…A major contributing factor to glioblastoma (GBM) development and progression is its ability to evade the immune system by creating an immune-suppressive…”
Get full text

Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach by Tranchevent, Léon-Charles, Nazarov, Petr V, Kaoma, Tony, Schmartz, Georges P, Muller, Arnaud, Kim, Sang-Yoon, Rajapakse, Jagath C, Azuaje, Francisco

“…One of the main current challenges in computational biology is to make sense of the huge amounts of multidimensional experimental data that are being produced…”
Get full text

Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus by Mgrditchian, Takouhie, Brown-Clay, Joshua, Hoffmann, Céline, Müller, Tanja, Filali, Liza, Ockfen, Elena, Mao, Xianqing, Moreau, Flora, Casellas, Carla Pou, Kaoma, Tony, Mittelbronn, Michel, Thomas, Clément

“…The actin cytoskeleton plays a critical role in cancer cell invasion and metastasis; however, the coordination of its multiple functions remains unclear. Actin…”
Get full text

Hub genes in a pan-cancer co-expression network show potential for predicting drug responses [version 2; peer review: 2 approved] by Azuaje, Francisco, Kaoma, Tony, Jeanty, Céline, Nazarov, Petr V, Muller, Arnaud, Kim, Sang-Yoon, Dittmar, Gunnar, Golebiewska, Anna, Niclou, Simone P

“…Background: The topological analysis of networks extracted from different types of "omics" data is a useful strategy for characterizing biologically meaningful…”
Get full text