Search Results - "Kao, W.‐Y."

Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of mucopolysaccharidosis VII mice by Coulson‐Thomas, Vivien Jane, Caterson, Bruce, Kao, Winston W.‐Y.

“…Mucopolysaccharidosis (MPS) are a family of related disorders caused by a mutation in one of the lysosomal exoglycosidases which leads to the accumulation of…”
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Letter: the role of direct‐acting anti‐virals in determining the risk of hepatocellular carcinoma development in patients with hepatitis C virus‐induced cirrhosis by Kao, W.‐Y., Su, C.‐W.

“…Linked content This article is linked to Mettke et al and Mettke and Wedemeyer papers. To view these articles visit https://doi.org/10.1111/apt.14427 and…”
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Stem Cell Therapy Restores Transparency to Defective Murine Corneas by Du, Yiqin, Carlson, Eric C., Funderburgh, Martha L., Birk, David E., Pearlman, Eric, Guo, Naxin, Kao, Winston W.‐Y., Funderburgh, James L.

“…Corneal scarring from trauma and inflammation disrupts vision for millions worldwide, but corneal transplantation, the primary therapy for corneal blindness,…”
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Cell Therapy of Corneal Diseases by Kao, Winston W.-Y, Coulson-Thomas, Vivien J

“…Mesenchymal stem cells isolated from connective tissues are pluripotent and differentiate into phenotypes of connective tissue cell lineages (osteoblasts,…”
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Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice by Liu, Hongshan, Zhang, Jianhua, Liu, Chia-Yang, Wang, I-Jong, Sieber, Martin, Chang, John, Jester, James V, Kao, Winston W Y

“…Keratoplasty is the most effective treatment for corneal blindness, but suboptimal medical conditions and lack of qualified medical personnel and donated…”
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Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype by Liu, Hongshan, Zhang, Jianhua, Liu, Chia‐Yang, Hayashi, Yasuhito, Kao, Winston W.‐Y.

“…It remains elusive as to what bone marrow (BM) cell types infiltrate into injured and/or diseased tissues and subsequently differentiate to assume the…”
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Updated thresholds for serum alanine aminotransferase level in a large-scale population study composed of 34 346 subjects by Wu, W.-C., Wu, C.-Y., Wang, Y.-J., Hung, H.-H., Yang, H.-I., Kao, W.-Y., Su, C.-W., Wu, J.-C., Chan, W.-L., Lin, H.-C., Lee, F.-Y., Lee, S.-D.

“…Summary Background The sensitivity of current upper limit of normal (ULN) of serum alanine aminotransferase (ALT) levels for detecting chronic liver disease…”
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Transient expression of Wnt5a elicits ocular features of pseudoexfoliation syndrome in mice by Yuan, Yong, Schlötzer-Schrehardt, Ursula, Ritch, Robert, Call, Mindy, Chu, Fred B, Dong, Fei, Rice, Taylor, Zhang, Jianhua, Kao, Winston W-Y

“…Pseudoexfoliation (PEX) syndrome is an age-related systemic disease with ocular manifestations. The development of animal models is critical in order to…”
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Keratin expression by corneal and limbal stem cells during development by Kao, Winston W.-Y.

“…Keratins are the forming units of intermediate filaments (IF) that provide mechanical support, and formation of desmosomes between cells and hemi desmosomes…”
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Role of EGF receptor signaling on morphogenesis of eyelid and meibomian glands by Dong, Fei, Call, Mindy, Xia, Ying, Kao, Winston W-Y.

“…The epidermal growth factor receptor (EGFR) signaling has a pivotal role in the regulation of morphogenesis during development and maintenance of homeostasis…”
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Lumican Peptides: Rational Design Targeting ALK5/TGFBRI by Gesteira, Tarsis Ferreira, Coulson-Thomas, Vivien J., Yuan, Yong, Zhang, Jianhua, Nader, Helena B., Kao, Winston W.-Y.

“…Lumican, a small leucine rich proteoglycan (SLRP), is a component of extracellular matrix which also functions as a matrikine regulating multiple cell…”
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Expression and role of lumican in acute aortic dissection: A human and mouse study by Chen, Shao-Wei, Chou, Shing-Hsien, Tung, Ying-Chang, Hsiao, Fu-Chih, Ho, Chien-Te, Chan, Yi-Hsin, Wu, Victor Chien-Chia, Chou, An-Hsun, Hsu, Ming-En, Lin, Pyng-Jing, Kao, Winston W. Y, Chu, Pao-Hsien

“…Introduction Aortic dissection (AD) is a life-threatening emergency, and lumican (LUM) is a potential Biomarker for AD diagnosis. We investigated LUM…”
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Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling by Yuan, Yong, Call, Mindy K, Yuan, Yan, Zhang, Yujin, Fischesser, Katy, Liu, Chia-Yang, Kao, Winston W-Y

“…Dexamethasone (DEX) regulates aqueous humor outflow by inducing a reorganization of the cytoskeleton to form cross-linked actin networks (CLANs) in trabecular…”
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Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System by Coulson-Thomas, Vivien J., PhD, Coulson-Thomas, Yvette M., PhD, Gesteira, Tarsis F., PhD, Kao, Winston W.-Y., PhD

“…Abstract Mesenchymal stem cells (MSCs) are a group of fibroblast-like multipotent mesenchymal stromal cells that have the ability to differentiate into…”
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TRPV1 Involvement in Inflammatory Tissue Fibrosis in Mice by Okada, Yuka, Reinach, Peter S, Shirai, Kumi, Kitano, Ai, Kao, Winston W.-Y, Flanders, Kathleen C, Miyajima, Masayasu, Liu, Hongshan, Zhang, Jianhua, Saika, Shizuya

“…We examined whether absence or blocking of transient receptor potential vanilloid subtype 1 (TRPV1) affects the level of inflammation and fibrosis/scarring…”
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Generation and Characterization of a Novel Mouse Line, Keratocan-rtTA (KeraRT), for Corneal Stroma and Tendon Research by Zhang, Yujin, Kao, Winston W-Y, Hayashi, Yasuhito, Zhang, Lingling, Call, Mindy, Dong, Fei, Yuan, Yong, Zhang, Jianhua, Wang, Yen-Chiao, Yuka, Okada, Shiraishi, Atsushi, Liu, Chia-Yang

“…We created a novel inducible mouse line Keratocan-rtTA (KeraRT) that allows specific genetic modification in corneal keratocytes and tenocytes during…”
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Lumican expression, localization and antitumor activity in prostate cancer by Coulson-Thomas, Vivien J., Coulson-Thomas, Yvette M., Gesteira, Tarsis F., Andrade de Paula, Claudia A., Carneiro, Celia R.W., Ortiz, Valdemar, Toma, Leny, Kao, Winston W.-Y., Nader, Helena B.

“…The stromal reaction surrounding tumors leads to the formation of a tumor-specific microenvironment, which may play either a restrictive role or a supportive…”
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Cancer risk in patients with pyogenic liver abscess: a nationwide cohort study by Kao, W.-Y., Hwang, C.-Y., Chang, Y.-T., Su, C.-W., Hou, M.-C., Lin, H.-C., Lee, F.-Y., Lee, S.-D., Wu, J.-C.

“…Summary Background There has been no large‐scale population‐based study on the relationship between pyogenic liver abscesses (PLA) and subsequent cancer risk…”
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Serum alpha-fetoprotein response can predict prognosis in hepatocellular carcinoma patients undergoing radiofrequency ablation therapy by Kao, W.-Y, Chiou, Y.-Y, Hung, H.-H, Su, C.-W, Chou, Y.-H, Wu, J.-C, Huo, T.-I, Huang, Y.-H, Wu, W.-C, Lin, H.-C, Lee, S.-D

“…Aims To evaluate the clinical inference of serum alpha-fetoprotein (AFP) response in hepatocellular carcinoma (HCC) patients undergoing percutaneous…”
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Lumican is required for neutrophil extravasation following corneal injury and wound healing by Hayashi, Yasuhito, Call, Mindy K, Chikama, Tai-ichiro, Liu, Hongshan, Carlson, Eric C, Sun, Yan, Pearlman, Eric, Funderburgh, James L, Babcock, George, Liu, Chia-Yang, Ohashi, Yuichi, Kao, Winston W.-Y

“…An important aspect of wound healing is the recruitment of neutrophils to the site of infection or tissue injury. Lumican, an extracellular matrix component…”
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