Search Results - "Kanzok, Stefan M"

The evolutionarily conserved PhLP3 is essential for sperm development in Drosophila melanogaster by Petit, Christopher, Kojak, Elizabeth, Webster, Samantha, Marra, Michela, Sweeney, Brendan, Chaikin, Claire, Jemc, Jennifer C, Kanzok, Stefan M

“…Phosducin-like proteins (PhLP) are thioredoxin domain-containing proteins that are highly conserved across unicellular and multicellular organisms. PhLP family…”
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Transposon mutagenesis identifies genes essential for Plasmodium falciparum gametocytogenesis by Ikadai, Hiromi, Shaw Saliba, Kathryn, Kanzok, Stefan M., McLean, Kyle J., Tanaka, Takeshi Q., Cao, Jun, Williamson, Kim C., Jacobs-Lorena, Marcelo

“…Gametocytes are essential for Plasmodium transmission, but little is known about the mechanisms that lead to their formation. Using piggyBac…”
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Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut by Vega-Rodríguez, Joel, Ghosh, Anil K, Kanzok, Stefan M, Dinglasan, Rhoel R, Wang, Sibao, Bongio, Nicholas J, Kalume, Dario E, Miura, Kazutoyo, Long, Carole A, Pandey, Akhilesh, Jacobs-Lorena, Marcelo

“…Plasmodium ookinete invasion of the mosquito midgut is a crucial step of the parasite life cycle but little is known about the molecular mechanisms involved…”
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Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen by Dinglasan, Rhoel R, Kalume, Dario E, Kanzok, Stefan M, Ghosh, Anil K, Muratova, Olga, Pandey, Akhilesh, Jacobs-Lorena, Marcelo

“…Malaria parasites must undergo development within mosquitoes to be transmitted to a new host. Antivector transmission-blocking vaccines inhibit parasite…”
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Characterization of a protozoan Phosducin-like protein-3 (PhLP-3) reveals conserved redox activity by Kooistra, Rachel L, David, Robin, Ruiz, Ana C, Powers, Sean W, Haselton, Kyle J, Kiernan, Kaitlyn, Blagborough, Andrew M, Solamen, Ligin, Olsen, Kenneth W, Putonti, Catherine, Kanzok, Stefan M

“…We recently identified three novel thioredoxin-like genes in the genome of the protozoan parasite Plasmodium that belong to the Phosducin-like family of…”
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The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca2+ Homeostasis by Targeting a Unique Ion Channel by Gupta, Yash, Sharma, Neha, Singh, Snigdha, Romero, Jesus G., Rajendran, Vinoth, Mogire, Reagan M., Kashif, Mohammad, Beach, Jordan, Jeske, Walter, Poonam, Ogutu, Bernhards R., Kanzok, Stefan M., Akala, Hoseah M., Legac, Jennifer, Rosenthal, Philip J., Rademacher, David J., Durvasula, Ravi, Singh, Agam P., Rathi, Brijesh, Kempaiah, Prakasha

“…Malaria elimination urgently needs novel antimalarial therapies that transcend resistance, toxicity, and high costs. Our multicentric international…”
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Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae by Meister, S, Kanzok, S.M, Zheng, X.I, Luna, C, Li, T.R, Hoa, N.T, Clayton, J.R, White, K.P, Kafatos, F.C, Christophides, G.K

“…We show that, in the malaria vector Anopheles gambiae, expression of Cecropin 1 is regulated by REL2, an NF-kappaB-like transcription factor orthologous to…”
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Ribosomal/nucleolar stress induction regulates tert-Butyl hydroperoxide (tBHP) mediated oxidative stress in Anopheles gambiae midguts by Tarimo, Brian B, Hritzo, Bernadette A, Law, Henry Chun Hin, Tao, Dingyin, Pastrana-Mena, Rebecca, Kanzok, Stefan M, Buza, Joram J, Dinglasan, Rhoel R

“…A fundamental understanding of redox homeostasis in Anopheles gambiae midgut cells under different oxidative conditions is missing. Such knowledge can aid in…”
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Expression of cytosolic peroxiredoxins in Plasmodium berghei ookinetes is regulated by environmental factors in the mosquito bloodmeal by Turturice, Benjamin A, Lamm, Michael A, Tasch, James J, Zalewski, Angelika, Kooistra, Rachel, Schroeter, Eric H, Sharma, Sapna, Kawazu, Shin-Ichiro, Kanzok, Stefan M

“…The Plasmodium ookinete develops over several hours in the bloodmeal of its mosquito vector where it is exposed to exogenous stresses, including cytotoxic…”
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Entomopathogenic fungi as biological insecticides to control malaria by Kanzok, Stefan M., Jacobs-Lorena, Marcelo

“…Malaria is arguably the most serious vector-borne disease worldwide. The already-alarming number of deaths caused by malaria is increasing, caused in part by…”
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Molecular cloning, characterization and expression profile of a glutathione peroxidase-like thioredoxin peroxidase (TPxGl ) of the rodent malaria parasite Plasmodium berghei by Haselton, Kyle J, David, Robin, Fell, Katherine, Schulte, Emily, Dybas, Matthew, Olsen, Kenneth W, Kanzok, Stefan M

“…Abstract Glutathione peroxidases (GPx) comprise an important group of redox active proteins with diverse functions, including antioxidant defense and…”
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Paraquat-Mediated Oxidative Stress in Anopheles gambiae Mosquitoes Is Regulated by An Endoplasmic Reticulum (ER) Stress Response by Tarimo, Brian B, Law, Henry Chun Hin, Tao, Dingyin, Pastrana-Mena, Rebecca, Kanzok, Stefan M, Buza, Joram J, Dinglasan, Rhoel R

“…Paraquat is a potent superoxide (O₂ )-inducing agent that is capable of inducing an oxidative imbalance in the mosquito midgut. This oxidative imbalance can…”
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The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites by Gupta, Yash, Goicoechea, Steven, Pearce, Catherine M., Mathur, Raman, Romero, Jesus G., Kwofie, Samuel K., Weyenberg, Matthew C., Daravath, Bharathi, Sharma, Neha, Poonam, Akala, Hoseah M., Kanzok, Stefan M., Durvasula, Ravi, Rathi, Brijesh, Kempaiah, Prakasha

“…Calcium channels (CCs), a group of ubiquitously expressed membrane proteins, are involved in many pathophysiological processes of protozoan parasites. Our…”
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Origin of Toll-like receptor-mediated innate immunity by Kanzok, Stefan M, Hoa, Ngo T, Bonizzoni, Mariangela, Luna, Coralia, Huang, Yaming, Malacrida, Anna R, Zheng, Liangbiao

“…Toll-related receptors (TLR) have been found in four animal phyla: Nematoda, Arthropoda, Echinodermata, and Chordata. No TLR has been identified thus far in…”
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The Thioredoxin System of the Malaria Parasite Plasmodium falciparum by Kanzok, Stefan M., Schirmer, R. Heiner, Türbachova, Ivana, Iozef, Rimma, Becker, Katja

“…In most living cells, redox homeostasis is based both on the glutathione and the thioredoxin system. In the malaria parasite Plasmodium falciparum…”
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Stress response pathways in protozoan parasites by Vonlaufen, Nathalie, Kanzok, Stefan M., Wek, Ronald C., Sullivan Jr, William J.

“…Summary Diseases caused by protozoan parasites have a dramatic impact on world health. Emerging drug resistance and a general lack of experimental…”
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Substitution of the Thioredoxin System for Glutathione Reductase in Drosophila melanogaster by Kanzok, Stefan M., Fechner, Anke, Bauer, Holger, Ulschmid, Julia K., Müller, Hans-Michael, Botella-Munoz, José, Schneuwly, Stephan, Schirmer, R. Heiner, Becker, Katja

“…The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins…”
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The evolution and putative function of phosducin-like proteins in the malaria parasite Plasmodium by Putonti, Catherine, Quach, Bryan, Kooistra, Rachel L., Kanzok, Stefan M.

“…► Characterized three Plasmodium genes belonging to the phosducin-like protein family. ► Identified evidence of gene loss and duplication in PhLP gene family…”
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Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin peroxidase-1 from Drosophila melanogaster: isolation and characterization of a second thioredoxin in D. Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2 by Bauer, Holger, Kanzok, Stefan M, Schirmer, R Heiner

“…As Drosophila melanogaster does not contain glutathione reductase, the thioredoxin system has a key function for glutathione disulfide reduction in insects…”
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Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum by Kanzok, Stefan M, Rahlfs, Stefan, Becker, Katja, Schirmer, R Heiner

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