Data on somatic mutations obtained by whole exome sequencing of FFPE tissue samples from Russian patients with prostate cancer

Prostate cancer (PCa) is the most frequently diagnosed among men malignant disease that remains poorly characterized at the molecular level. Advanced PCa is not curable, and the current treatment methods can only increase the life expectancy by several months. Identification of the genetic aberratio...

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Bibliographic Details
Published in:	Data in brief Vol. 25; p. 104022
Main Authors:	Nikitina, A.S., Sharova, E.I., Danilenko, S.A., Selezneva, O.V., Skorodumova, L.O., Kanygina, A.V., Babalyan, K.A., Vasiliev, A.O., Govorov, A.V., Prilepskaya, E.A., Pushkar, D.Y., Kostryukova, E.S., Generozov, E.V.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-08-2019 Elsevier
Subjects:	Biochemistry, Genetics and Molecular Biology Prostate cancer Somatic variants Whole exome Somatic variants Prostate cancer Whole exome
Online Access:	Get full text
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Summary:	Prostate cancer (PCa) is the most frequently diagnosed among men malignant disease that remains poorly characterized at the molecular level. Advanced PCa is not curable, and the current treatment methods can only increase the life expectancy by several months. Identification of the genetic aberrations in tumor cells provides clues to understanding the mechanisms of PCa pathogenesis and the basis for developing new therapeutic approaches. Here we present data on somatic mutations, namely single nucleotide variations (SNVs), small insertions and deletions, detected in prostate tumor tissue obtained from Russian patients with PCa. Moreover, we provide a raw dataset on the whole exome and targeted DNA sequencing of tumor and non-tumor prostate tissue obtained from Russian patients with PCa and benign prostatic hyperplasia (BPH). This data is available at NCBI Sequence Read Archive under Accession No. PRJNA506922.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2352-3409 2352-3409
DOI:	10.1016/j.dib.2019.104022