Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review)
KIM-1 (kidney injury molecule 1) is a transmembrane glycoprotein also known as HAVcr-1 and TIM-1 belongs to the T-cell immunoglobulin and mucin domain family (TIM) of proteins. TIM glycoproteins are presented on the immune cells and participate in the regulation of immune reactions. KIM-1 differs fr...
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| Published in: | Sovremennye tekhnologii v medit͡s︡ine Vol. 13; no. 3; pp. 64 - 78 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Russia (Federation)
Privolzhsky Research Medical University
01-01-2021
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | KIM-1 (kidney injury molecule 1) is a transmembrane glycoprotein also known as HAVcr-1 and TIM-1 belongs to the T-cell immunoglobulin and mucin domain family (TIM) of proteins. TIM glycoproteins are presented on the immune cells and participate in the regulation of immune reactions. KIM-1 differs from other members of its family in that it is expressed not only by immunocompetent cells but epithelial cells as well. Cellular and humoral effects mediated by KIM-1 are involved in a variety of physiological and pathophysiological processes. Current understanding of the mechanisms determining the participation of KIM-1 in viral invasion, the immune response regulation, adaptive reactions of the kidney epithelium to acute ischemic or toxic injury, in progression of chronic renal diseases, and kidney cancer development have been presented in this review. Data of clinical researches demonstrating the association of KIM-1 with viral diseases and immune disorders have also been analyzed. Potential application of KIM-1 as urinary or serological marker in renal and cardiovascular diseases has been considered. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Conflicts of interest. The authors have no conflicts of interest to declare. Authors’ contribution: T.A. Karmakova analyzed scientific information on molecular biological and immunological aspects of the problem, wrote appropriate sections for the manuscript; N.S. Sergeeva worked out the conception and design of the review, analyzed scientific information on medico-biological aspects, wrote appropriate sections of the manuscript; K.Yu. Kanukoev analyzed scientific information on clinical aspects of the problem, wrote appropriate sections of the manuscript; B.Ya. Alekseev was responsible for critical analysis and revision of the clinical sections; A.D. Kaprin was involved in the critical analysis of the manuscript and introduction of a valuable intellectual content. How to cite: Karmakova Т.А., Sergeeva N.S., Kanukoev К.Yu., Alekseev B.Ya., Kaprin А.D. Kidney injury molecule 1 (KIM-1): a multifunctional glycoprotein and biological marker (review). Sovremennye tehnologii v medicine 2021; 13(3): 64, https://doi.org/10.17691/stm2021.13.3.08 |
| ISSN: | 2076-4243 2309-995X |
| DOI: | 10.17691/stm2021.13.3.08 |