Search Results - "Kantorow, Marc"

Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone by Gheyas, Rifah, Ortega-Alvarez, Ramon, Chauss, Daniel, Kantorow, Marc, Menko, A. Sue

“…The terminal steps of lens cell differentiation require elimination of all organelles to create a central Organelle Free Zone (OFZ) that is required for lens…”
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BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation by Brennan, Lisa A., McGreal-Estrada, Rebecca, Logan, Caitlin M., Cvekl, Ales, Menko, A. Sue, Kantorow, Marc

“…The formation and life-long growth of the ocular lens depends on the continuous differentiation of lens epithelial cells into lens fiber cells. To achieve…”
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A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis by Disatham, Joshua, Brennan, Lisa, Chauss, Daniel, Kantorow, Jason, Afzali, Behdad, Kantorow, Marc

“…During eye lens development the embryonic vasculature regresses leaving the lens without a direct oxygen source. Both embryonically and throughout adult life,…”
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Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency by Disatham, Joshua, Brennan, Lisa, Cvekl, Ales, Kantorow, Marc

“…Recent advances in next-generation sequencing and data analysis have provided new gateways for identification of novel genome-wide genetic determinants…”
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Mutations in FYCO1 Cause Autosomal-Recessive Congenital Cataracts by JIANJUN CHEN, ZHIWEI MA, AMER RIAZUDDIN, S, FIELDING HEJTMANCIK, J, XIAODONG JIAO, FARISS, Robert, LEE KANTOROW, Wanda, KANTOROW, Marc, PRAS, Eran, FRYDMAN, Moshe, PRAS, Elon, RIAZUDDIN, Sheikh

“…Congenital cataracts (CCs), responsible for about one-third of blindness in infants, are a major cause of vision loss in children worldwide…”
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Novel mitochondrial derived Nuclear Excisosome degrades nuclei during differentiation of prosimian Galago (bush baby) monkey lenses by Costello, M Joseph, Gilliland, Kurt O, Mohamed, Ashik, Schey, Kevin L, Johnsen, Sönke, Brennan, Lisa A, Kantorow, Marc

“…The unique cellular organization and transparent function of the ocular lens depend on the continuous differentiation of immature epithelial cells on the lens…”
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Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation by Disatham, Joshua, Brennan, Lisa, Jiao, Xiaodong, Ma, Zhiwei, Hejtmancik, J Fielding, Kantorow, Marc

“…Methylation at cytosines (mCG) is a well-known regulator of gene expression, but its requirements for cellular differentiation have yet to be fully elucidated…”
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Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation by He, Shuying, Limi, Saima, McGreal, Rebecca S, Xie, Qing, Brennan, Lisa A, Kantorow, Wanda Lee, Kokavec, Juraj, Majumdar, Romit, Hou, Jr, Harry, Edelmann, Winfried, Liu, Wei, Ashery-Padan, Ruth, Zavadil, Jiri, Kantorow, Marc, Skoultchi, Arthur I, Stopka, Tomas, Cvekl, Ales

“…Ocular lens morphogenesis is a model for investigating mechanisms of cellular differentiation, spatial and temporal gene expression control, and chromatin…”
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Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells by Costello, M Joseph, Brennan, Lisa A, Mohamed, Ashik, Gilliland, Kurt O, Johnsen, Sönke, Kantorow, Marc

“…An unresolved issue in structural biology is how the encapsulated lens removes membranous organelles to carry out its role as a transparent optical element. In…”
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Autophagy Requirements for Eye Lens Differentiation and Transparency by Brennan, Lisa, Costello, M Joseph, Hejtmancik, J Fielding, Menko, A Sue, Riazuddin, S Amer, Shiels, Alan, Kantorow, Marc

“…Recent evidence points to autophagy as an essential cellular requirement for achieving the mature structure, homeostasis, and transparency of the lens…”
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TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens by Brennan, Lisa A, Lee, Wanda, Kantorow, Marc

“…A key feature of many age-related diseases is the oxidative stress-induced accumulation of protein methionine sulfoxide (PMSO) which causes lost protein…”
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Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens by Chauss, Daniel, Basu, Subhasree, Rajakaruna, Suren, Ma, Zhiwei, Gau, Victoria, Anastas, Sara, Brennan, Lisa A, Hejtmancik, J Fielding, Menko, A Sue, Kantorow, Marc

“…The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the…”
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Thionein Can Serve as a Reducing Agent for the Methionine Sulfoxide Reductases by Sagher, Daphna, Brunell, David, Hejtmancik, J. Fielding, Kantorow, Marc, Brot, Nathan, Weissbach, Herbert

“…It has been generally accepted, primarily from studies on methionine sulfoxide reductase (Msr) A, that the biological reducing agent for the members of the Msr…”
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Methionine Sulfoxide Reductase A Is Important for Lens Cell Viability and Resistance to Oxidative Stress by Kantorow, Marc, Hawse, John R., Cowell, Tracy L., Benhamed, Sonia, Pizarro, Gresin O., Reddy, Venkat N., Hejtmancik, J. F., Weissbach, Herbert

“…Age-related cataract, an opacity of the eye lens, is the leading cause of visual impairment in the elderly, the etiology of which is related to oxidative…”
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Mechanisms of organelle elimination for lens development and differentiation by Brennan, Lisa, Disatham, Joshua, Kantorow, Marc

“…A hallmark feature of lens development and differentiation is the complete elimination of organelles from the center of the eye lens. A long unanswered…”
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Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a by Brennan, Lisa, Disatham, Joshua, Kantorow, Marc

“…Formation of the eye lens depends on the continuous differentiation of lens epithelial cells into lens fiber cells. To attain their mature structure and…”
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α-Crystallin/Small Heat Shock Protein has Autokinase Activity by KANTOROW, M, PIATIGORSKY, J

“…The α-crystallins (α A and α B) are major water-soluble proteins of the transparent eye lens that are expressed in a variety of tissues and can function as…”
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Parkin elimination of mitochondria is important for maintenance of lens epithelial cell ROS levels and survival upon oxidative stress exposure by Brennan, Lisa, Khoury, Josef, Kantorow, Marc

“…Age-related cataract is associated with oxidative stress and death of lens epithelial cells (LECs) whose survival is dependent on functional mitochondrial…”
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Evidence for Gelsolin as a Corneal Crystallin in Zebrafish by Xu, Yong-Sheng, Kantorow, Marc, Davis, Janine, Piatigorsky, Joram

“…We have shown that gelsolin is one of the most prevalent water-soluble proteins in the transparent cornea of zebrafish. There are also significant amounts of…”
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Multiomic analysis implicates FOXO4 in genetic regulation of chick lens fiber cell differentiation by Brennan, Lisa, Disatham, Joshua, Menko, A. Sue, Kantorow, Marc

“…A classic model for identification of novel differentiation mechanisms and pathways is the eye lens that consists of a monolayer of quiescent epithelial cells…”
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