Search Results - "Kantorow, M"

Deletion of mouse MsrA results in HBO-induced cataract: MsrA repairs mitochondrial cytochrome c by Brennan, L A, Lee, W, Cowell, T, Giblin, F, Kantorow, M

“…Considerable evidence indicates a role for methionine sulfoxide reductase A (MsrA) in lens cell resistance to oxidative stress through its maintenance of…”
Get full text

Identification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses by Hawse, J.R., Hejtmancik, J.F., Horwitz, J., Kantorow, M.

“…We have examined the gene expression profiles of young, old and cataractous human lenses in order to differentiate those gene expression changes specific for…”
Get full text

Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina by Lee, J.W., Gordiyenko, N.V., Marchetti, M., Tserentsoodol, N., Sagher, D., Alam, S., Weissbach, H., Kantorow, M., Rodriguez, I.R.

“…MSRA (EC 1.8.4.6) is a member of the methionine sulfoxide reductase family that can reduce methionine sulfoxide (MetO) in proteins. This repair function has…”
Get full text

α-Crystallin/Small Heat Shock Protein has Autokinase Activity by KANTOROW, M, PIATIGORSKY, J

“…The α-crystallins (α A and α B) are major water-soluble proteins of the transparent eye lens that are expressed in a variety of tissues and can function as…”
Get full text

Evidence for Gelsolin as a Corneal Crystallin in Zebrafish by Xu, Yong-Sheng, Kantorow, Marc, Davis, Janine, Piatigorsky, Joram

“…We have shown that gelsolin is one of the most prevalent water-soluble proteins in the transparent cornea of zebrafish. There are also significant amounts of…”
Get full text

Identification and Spatial Analysis of Metallothioneins Expressed by the Adult Human Lens by Oppermann, Brian, Zhang, Weiyan, Magabo, Kristine, Kantorow, Marc

“…Metallothioneins (MTs) are a large family of proteins involved in multiple protective pathways including binding of toxic metals, free radical scavenging, and…”
Get full text

Up-regulation of osteonectin/SPARC in age-related cataractous human lens epithelia by Kantorow, M, Horwitz, J, Carper, D

“…To characterize gene expression patterns between epithelia isolated from cataractous and normal human lenses. Reverse transcriptase differential display was…”
Get full text

Estrogen potentiates the combined effects of transforming growth factor-beta and tumor necrosis factor-alpha on adult human osteoblast-like cell prostaglandin E2 biosynthesis by Secreto, F J, Grover, A, Pacurari, M, Rice, M B, Kantorow, M, Bidwai, A P, Blaha, J D, Keeting, P E

“…Reports that estrogen treatment modulates arachidonic acid metabolism by bone and bone cells are found in the literature. However, conflicting indications of…”
Get full text

Osteonectin/SPARC Secreted by RPE and Localized to the Outer Plexiform Layer of the Monkey Retina by Rodriguez, Ignacio R, Moreira, Ernesto F, Bok, Dean, Kantorow, Marc

“…Osteonectin/SPARC is a secreted protein that has been implicated in ocular disease. Deletion of osteonectin/SPARC causes age-onset cataract in mice and the…”
Get full text

Escherichia coli cyclic AMP receptor protein mutants provide evidence for ligand contacts important in activation by MOORE, J, KANTOROW, M, VANDERZWAAG, D, MCKENNEY, K

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Molecular genetics of age-related cataract by Hejtmancik, J.Fielding, Kantorow, Marc

“…Advances in molecular biological and genetic technology have greatly accelerated elucidation of the genetic contribution to age-related cataract…”
Get full text

Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells by Brennan, Lisa Ann, Kantorow, Wanda Lee, Chauss, Daniel, McGreal, Rebecca, He, Shuying, Mattucci, Lyndzie, Wei, Jianning, Riazuddin, S Amer, Cvekl, Ales, Hejtmancik, J Fielding, Kantorow, Marc

“…Mutation of the autophagy gene FYVE (named after the four cysteine-rich proteins: Fab 1 [yeast orthologue of PIKfyve], YOTB, Vac 1 [vesicle transport protein],…”
Get full text

Methionine Sulfoxide Reductase A Is Important for Lens Cell Viability and Resistance to Oxidative Stress by Kantorow, Marc, Hawse, John R., Cowell, Tracy L., Benhamed, Sonia, Pizarro, Gresin O., Reddy, Venkat N., Hejtmancik, J. F., Weissbach, Herbert

“…Age-related cataract, an opacity of the eye lens, is the leading cause of visual impairment in the elderly, the etiology of which is related to oxidative…”
Get full text

Thioredoxin‐like protein 6 (TXNL6) is an H2O2‐inducible reducing system for methionine sulfoxide reductase A (MsrA) repair of oxidized proteins whose expression increases upon aging in the human lens by LEE KANTOROW, W, BRENNAN, L, MCGREAL, R, KANTOROW, M

“…Purpose TXNL6 is a thioredoxin‐like protein and we hypothesized that it could function as a reducing system for MsrA repair of methionine sulfoxide inactivated…”
Get full text

Methionine Sulfoxide Reductases B1, B2, and B3 Are Present in the Human Lens and Confer Oxidative Stress Resistance to Lens Cells by Marchetti, Maria A, Pizarro, Gresin O, Sagher, Daphna, DeAmicis, Candida, Brot, Nathan, Hejtmancik, J. Fielding, Weissbach, Herbert, Kantorow, Marc

“…Methionine-sulfoxide reductases are unique, in that their ability to repair oxidized proteins and MsrA, which reduces S-methionine sulfoxide, can protect lens…”
Get full text

MsrA repair of Cytochrome c and α‐crystallin links chaperone and oxidative repair pathways with mitochondrial protection and apoptotic control in lens cells by KANTOROW, M, BRENNAN, L, MCGREAL, R, LEE, W, DAVID, L, GIBLIN, F

“…Purpose Methionine sulfoxide reductase A (MsrA) is essential for lens defense against oxidative stress and cataract formation through its ability to repair…”
Get full text

Spectrum and Range of Oxidative Stress Responses of Human Lens Epithelial Cells to H2O2 Insult by Goswami, Sumanta, Sheets, Nancy L, Zavadil, Jiri, Chauhan, Bharesh K, Bottinger, Erwin P, Reddy, Venkat N, Kantorow, Marc, Cvekl, Ales

“…Oxidative stress (OS) is believed to be a major contributor to age-related cataract and other age-related diseases. cDNA microarrays were used to identify the…”
Get full text

Identification of global gene expression differences between human lens epithelial and cortical fiber cells reveals specific genes and their associated pathways important for specialized lens cell functions by Hawse, John R, DeAmicis-Tress, Candida, Cowell, Tracy L, Kantorow, Marc

“…In order to identify specific genes that may play important roles in maintaining the specialized functions of lens epithelial and fiber cells, we have analyzed…”
Get full text

Expression of βB2-Crystallin mRNA and protein in retina, brain, and testis by MAGABO, Kristine S, HORWITZ, Joseph, PIATIGORSKY, Joram, KANTOROW, Marc

Get full text

Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses by Hawse, John R, Hejtmancik, James F, Huang, Quingling, Sheets, Nancy L, Hosack, Douglas A, Lempicki, Richard A, Horwitz, Joseph, Kantorow, Marc

“…Age-related cataract is a multi-factorial disease with a poorly understood etiology. Numerous studies provide evidence that the human eye lens has evolved…”
Get full text