Search Results - "Kanthou, C"

Vascular endothelial growth factor (VEGF) isoform mediated tumour response to combination treatment with a blocking antibody to VEGFR-2 and radiotherapy by Mukherjee, D, Lunt, S.J, Fisher, M, English, W, Kanthou, C, Tozer, G

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An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A‐4 3‐O‐phosphate by Williams, L J, Mukherjee, D, Fisher, M, Reyes‐Aldasoro, C C, Akerman, S, Kanthou, C, Tozer, G M

“…Background and Purpose Combretastatin A‐4 3‐O‐phosphate (CA4P) is in clinical trial as a tumour vascular disrupting agent (VDA) but the cause of blood flow…”
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19. Activation of the endoplasmic reticulum stress pathway and the radiosensitivity of human colorectal adenocarcinoma by Drake, T, Ritchie, J.E, Kanthou, C, Wyld, L

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Acute intraoperative heparin-induced thrombocytopenia (HIT) and thrombosis during coronary artery bypass grafting: Two case reports providing evidence for the role of preoperative LMWH in triggering sensitization by Khoury, M, Pitsis, A, Poumpouridou-Kioura, H, Soufla, G, Kanthou, C, Matoula, N, Angelidis, A, Melissari, E

“…Abstract Introduction Systemic anticoagulation is necessary during cardiac surgery. To date, the only well established anticoagulation protocol involves the…”
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An automatic algorithm for the segmentation and morphological analysis of microvessels in immunostained histological tumour sections by REYES‐ALDASORO, C.C., WILLIAMS, L.J., AKERMAN, S., KANTHOU, C., TOZER, G.M.

“…Summary A fully automatic segmentation and morphological analysis algorithm for the analysis of microvessels from CD31 immunostained histological tumour…”
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Targeting the endoplasmic reticulum mediates radiation sensitivity in colorectal cancer by Drake, T.M., Ritchie, J.E., Kanthou, C., Staves, J.J., Narramore, R., Wyld, L.

“…Radiotherapy is an established treatment modality for early and locally advanced rectal cancer as part of short course radiotherapy and long course…”
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Tumour vascular disrupting agents : combating treatment resistance by TOZER, G. M, KANTHOU, C, LEWIS, G, PRISE, V. E, VOJNOVIC, B, HILL, S. A

“…A large group of tubulin-binding microtubule-depolymerizing agents act as tumour vascular disrupting agents (VDAs). Several members of this group are now in…”
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Limitations of the reporter green fluorescent protein under simulated tumor conditions by CORALLI, Claudia, CEMAZAR, Maja, KANTHOU, Chryso, TOZER, Gillian M, DACHS, Gabi U

“…This paper reports a detailed analysis of the effect of low oxygen conditions (hypoxia) on the reporter green fluorescent protein (GFP). It questions the…”
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Disrupting tumour blood vessels by Tozer, Gillian M, Kanthou, Chryso, Baguley, Bruce C

“…Low-molecular-weight vascular-disrupting agents (VDAs) cause a pronounced shutdown in blood flow to solid tumours, resulting in extensive tumour-cell necrosis,…”
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Use of low molecular weight heparin in pregnancy by Melissari, E, Parker, C J, Wilson, N V, Monte, G, Kanthou, C, Pemberton, K D, Nicolaides, K H, Barrett, J J, Kakkar, V V

“…In a controlled study of 15 pregnant patients undergoing therapeutic termination of pregnancy, seven received subcutaneously 5,000 anti-FXa units of low…”
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The proliferative responsiveness of human vascular smooth muscle cells to endothelin correlates with endothelin receptor density by Kanse, S M, Wijelath, E, Kanthou, C, Newman, P, Kakkar, V V

“…Endothelin (ET), a potent vasoconstrictor peptide, is implicated in disorders of intimal hyperplasia such as atherosclerosis and restenosis. Data from animal…”
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649 - Vascular endothelial growth factor (VEGF) isoform mediated tumour response to combination treatment with a blocking antibody to VEGFR-2 and radiotherapy by Mukherjee, D., Lunt, S.J., Fisher, M., English, W., Kanthou, C., Tozer, G.

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The tumor vascular targeting agent combretastatin A–4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells by Kanthou, Chryso, Tozer, Gillian M.

“…Combretastatin A–4-phosphate (CA-4-P) is a tubulin-binding compound currently in clinical trial as a tumor vascular-targeting agent. In endothelial cells,…”
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The Tubulin-Binding Agent Combretastatin A-4-Phosphate Arrests Endothelial Cells in Mitosis and Induces Mitotic Cell Death by Kanthou, Chryso, Greco, Olga, Stratford, Anna, Cook, Ian, Knight, Richard, Benzakour, Omar, Tozer, Gillian

“…The tubulin-binding agent combretastatin A-4-phosphate (CA-4-P), rapidly disrupts the vascular network of tumors leading to secondary tumor cell death. In…”
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Evidence for a protein S receptor(s) on human vascular smooth muscle cells. Analysis of the binding characteristics and mitogenic properties of protein S on human vascular smooth muscle cells by Benzakour, O, Formstone, C, Rahman, S, Kanthou, C, Dennehy, U, Scully, M F, Kakkar, V V, Cooper, D N

“…The presence of specific binding sites for the coagulation factor protein S (PS) on the surface of human vascular smooth muscle cells (HVSMC) is described. The…”
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Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells by Kanthou, C, Benzakour, O, Patel, G, Deadman, J, Kakkar, V V, Lupu, F

“…The synthetic peptide SFLLRNPNDKYEPF, identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage of thrombin, acts a…”
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An in vivo role for R ho kinase activation in the tumour vascular disrupting activity of combretastatin A ‐4 3‐ O ‐phosphate by Williams, L J, Mukherjee, D, Fisher, M, Reyes‐Aldasoro, C C, Akerman, S, Kanthou, C, Tozer, G M

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Evaluation of the use of the luciferase-reporter-gene system for gene-regulation studies involving cyclic AMP-elevating agents by Benzakour, O, Kanthou, C, Dennehy, U, al Haq, A, Berg, L P, Kakkar, V V, Cooper, D N

“…The effects of cyclic AMP (cAMP)-elevating agents on the activity of cis-acting gene promoter sequences are frequently studied using the…”
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The biology of the combretastatins as tumour vascular targeting agents by TOZER, GILLIAN M., KANTHOU, CHRYSO, PARKINS, CHARLES S., HILL, SALLY A.

“…Summary The tumour vasculature is an attractive target for therapy. Combretastatin A‐4 (CA‐4) and A‐1 (CA‐1) are tubulin binding agents, structurally related…”
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Structural domains of thrombin involved in the induction of mitogenesis in cultured human vascular smooth muscle cells by Kanthou, C, Dennehy, U, Kakkar, V V, Benzakour, O

“…Human alpha-thrombin is a known human vascular smooth muscle cell (HVSMC) mitogen. We have previously reported that gamma-thrombin, in which the anion binding…”
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