Search Results - "Kanoo, Sadhana"

Wnt-β Catenin Signaling Pathway: A Major Player in the Injury Induced Fibrosis and Dysfunction of the External Anal Sphincter by Rajasekaran, M. Raj, Kanoo, Sadhana, Fu, Johnny, Bhargava, Valmik, Mittal, Ravinder K.

“…Wnt-β catenin is an important signaling pathway in the genesis of fibrosis in many organ systems. Our goal was to examine the role of Wnt pathway in the…”
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Involvement of phospholipase A2 pathway for the Indian red scorpion venom-induced augmentation of cardiopulmonary reflexes elicited by phenyldiguanide by KANOO, Sadhana, DESHPANDE, Shripad B

“…The present study was conducted to examine the role of phospholipase A(2) and prostaglandins in Indian red scorpion (Mesobuthus tamulus; MBT) venom-induced…”
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Transcriptomics of SGLT2-Positive Proximal Tubule S1 Segments in Mice: Response to Diabetes, SGLT1/2 Inhibition, or GLP1 Receptor Agonist: FR-OR40 by Kim, Young Chul, Das, Vivek, Kanoo, Sadhana, Stanford, Stephanie, Bottini, Nunzio, Karihaloo, Anil K., Vallon, Volker

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Western diet exacerbates aristolochic acid-induced nephropathy in mice by Oe, Yuji, Kim, Young Chul, Kanoo, Sadhana, A Goodluck, Helen, Lopez, Natalia, Maher, Pamela, Vallon, Volker

“…Abstract only Aristolochic acid (AA) ingestion causes Balkan nephropathy, characterized by tubular injury and progression to chronic kidney disease (CKD). AA…”
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Enhanced sensitivity to ischemia reperfusion injury in a mouse model of accelerated aging is associated with blunted upregulation of urine KIM1 by Goodluck, Helen, Lopez, Natalia, Oe, Yuji, Kanoo, Sadhana, Chul Kim, Young, Maher, Pamela, Vallon, Volker

“…Abstract only Objective: Advanced age enhances the risk of acute kidney injury (AKI) but the mechanisms remain unclear. Kidney injury molecule 1 (KIM1) is a…”
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SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy by Oe, Yuji, Kim, Young Chul, Sidorenko, Viktoriya S, Zhang, Haiyan, Kanoo, Sadhana, Lopez, Natalia, Goodluck, Helen A, Crespo-Masip, Maria, Vallon, Volker

“…Proximal tubular uptake of aristolochic acid (AA) forms aristolactam (AL)-DNA adducts, which cause a p53/p21-mediated DNA damage response and acute tubular…”
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399-P: Dapagliflozin Is Protective in a Murine Model of Balkan Nephropathy by OE, YUJI, CHUL KIM, YOUNG, SIDORENKO, VIKTORIYA S., KANOO, SADHANA, LOPEZ, NATALIA, GOODLUCK, HELEN A., VALLON, VOLKER

“…Episodes of acute kidney injury (AKI) increase the risk of chronic kidney disease (CKD). Proximal tubular uptake of aristolochic acid (AA) induces aristolactam…”
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Basal renal phenotype and response to induction of aristolochic acid nephropathy in mice lacking the neutral amino acid transporter B0AT1 (SLC6A19) by Navarro Garrido, Aleix, Kim, Young Chul, Goodluck, Helen, Kanoo, Sadhana, Crespo‐Masip, Maria, Bröer, Stefan, Vallon, Volker

“…Background B0AT1 (SLC6A19) mediates the reabsorption of neutral amino acids, including branched‐chain amino acids (BCAA), in the intestine and kidney…”
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Deletion of eNOS enhances kidney injury in BTBR ob/ob mice by Kanoo, Sadhana, Goodluck, Helen, Kim, Young Chul, Garrido, Aleix Navarro, Crespo‐Masip, Maria, Zhang, Haiyan, Villalobos, Romer Gonzalez, Ma, Li‐Jun, Vallon, Volker

“…Background ob/ob mice are a leptin deficient murine model of type 2 diabetes mellitus (T2DM), characterized by hyperphagia, obesity and hyperglycemia. ob/ob…”
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Age-related external anal sphincter muscle dysfunction and fibrosis: possible role of Wnt/β-catenin signaling pathways by Rajasekaran, M Raj, Kanoo, Sadhana, Fu, Johnny, Nguyen, My-Uyen Lilly, Bhargava, Valmik, Mittal, Ravinder K

“…Studies show an age-related increase in the prevalence of anal incontinence and sphincter muscle atrophy. The Wnt/β-catenin signaling pathway has been recently…”
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Involvement of phospholipase A sub(2) pathway for the Indian red scorpion venom-induced augmentation of cardiopulmonary reflexes elicited by phenyldiguanide by Kanoo, Sadhana, Deshpande, Shripad B

“…The present study was conducted to examine the role of phospholipase A sub(2) and prostaglandins in Indian red scorpion (Mesobuthus tamulus; MBT) venom-induced…”
Get full text

Involvement of phospholipase A 2 pathway for the Indian red scorpion venom-induced augmentation of cardiopulmonary reflexes elicited by phenyldiguanide by Kanoo, Sadhana, Deshpande, Shripad B.

“…The present study was conducted to examine the role of phospholipase A 2 and prostaglandins in Indian red scorpion ( Mesobuthus tamulus; MBT) venom-induced…”
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Sildenafil increases the force of right atrial contractions in vitro via the NO-guanylyl cyclase pathway involving β-adrenoceptor linked mechanisms by Kanoo, Sadhana, Deshpande, Shripad B.

“…Sildenafil, a drug used in the treatment of erectile dysfunction, is a phosphodiesterase 5A inhibitor that increases cyclic guanosine monophosphate (cGMP)…”
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Cardiac dysrhythmia produced by Mesobuthus tamulus venom involves NO-dependent G-Cyclase signaling pathway by Kanoo, Sadhana, Mandal, Maloy B., Alex, Anitha B., Deshpande, Shripad B.

“…Role of G-protein coupled pathways in modulating the cardiotoxic effects produced by Indian red scorpion ( Mesobuthus tamulus ) venom were examined. The…”
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Estrogen modulates in vitro atrial bradycardia induced by Indian red scorpion venom via G-protein coupled mechanisms by Alex, Anitha B., Kanoo, Sadhana, Deshpande, Shripad B.

“…Role of estrogen on cardiac dysrhythmia produced by Indian red scorpion ( Mesobuthus tamulus) venom was examined using rat right atrial preparations in vitro…”
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Bradycardia induced by Mesobuthus tamulus scorpion venom involves muscarinic receptor-G-protein-coupled cell signaling pathways by Deshpande, Shripad B, Kanoo, Sadhana, Alex, Anitha B

“…Indian red scorpion (Mesobuthus tamulus; MBT) envenomation produces various cardio-respiratory abnormalities including cardiac dysrhythmias. The underlying…”
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