Search Results - "Kanojia, Deepak"

FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis by Cordero, Alex, Kanojia, Deepak, Miska, Jason, Panek, Wojciech K., Xiao, Annie, Han, Yu, Bonamici, Nicolas, Zhou, Weidong, Xiao, Ting, Wu, Meijing, Ahmed, Atique U., Lesniak, Maciej S.

“…Overexpression of human epidermal growth factor receptor 2 (HER2) in breast cancer patients is associated with increased incidence of breast cancer brain…”
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GCN2 is essential for CD8+ T cell survival and function in murine models of malignant glioma by Rashidi, Aida, Miska, Jason, Lee-Chang, Catalina, Kanojia, Deepak, Panek, Wojciech K., Lopez-Rosas, Aurora, Zhang, Peng, Han, Yu, Xiao, Ting, Pituch, Katarzyna C., Kim, Julius W., Talebian, Mahsa, Fares, Jawad, Lesniak, Maciej S.

“…Amino acid deprivation is a strategy that malignancies utilize to blunt anti-tumor T-cell immune responses. It has been proposed that amino acid insufficiency…”
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Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade by Dmello, Crismita, Zhao, Junfei, Chen, Li, Gould, Andrew, Castro, Brandyn, Arrieta, Victor A., Zhang, Daniel Y., Kim, Kwang-Soo, Kanojia, Deepak, Zhang, Peng, Miska, Jason, Yeeravalli, Ragini, Habashy, Karl, Saganty, Ruth, Kang, Seong Jae, Fares, Jawad, Liu, Connor, Dunn, Gavin, Bartom, Elizabeth, Schipma, Matthew J., Hsu, Patrick D., Alghamri, Mahmoud S., Lesniak, Maciej S., Heimberger, Amy B., Rabadan, Raul, Lee-Chang, Catalina, Sonabend, Adam M.

“…Whereas the contribution of tumor microenvironment to the profound immune suppression of glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that…”
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Neural Stem Cells Secreting Anti‐HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases by Kanojia, Deepak, Balyasnikova, Irina V., Morshed, Ramin A., Frank, Richard T., Yu, Dou, Zhang, Lingjiao, Spencer, Drew A., Kim, Julius W., Han, Yu, Yu, Dihua, Ahmed, Atique U., Aboody, Karen S., Lesniak, Maciej S.

“…The treatment of human epidermal growth factor receptor 2 (HER2)‐overexpressing breast cancer has been revolutionized by trastuzumab. However, longer survival…”
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Targeting BET Proteins Decreases Hyaluronidase-1 in Pancreatic Cancer by Kumar, Krishan, Kanojia, Deepak, Bentrem, David J, Hwang, Rosa F, Butchar, Jonathan P, Tridandapani, Susheela, Munshi, Hidayatullah G

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of dense stroma that is enriched in hyaluronan (HA), with increased HA levels…”
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Nonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy by Liu, Xinfeng, Johnson, Sara, Liu, Shou, Kanojia, Deepak, Yue, Wei, Singh, Udai P., Wang, Qian, Wang, Qi, Nie, Qing, Chen, Hexin

“…Cancer stem cells (CSCs) have been identified in primary breast cancer tissues and cell lines. The CSC population varies widely among cancerous tissues and…”
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Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma by Dey, Mahua, Yu, Dou, Kanojia, Deepak, Li, Gina, Sukhanova, Madina, Spencer, Drew A., Pituch, Katatzyna C., Zhang, Lingjiao, Han, Yu, Ahmed, Atique U., Aboody, Karen S., Lesniak, Maciej S., Balyasnikova, Irina V.

“…The challenges to effective drug delivery to brain tumors are twofold: (1) there is a lack of non-invasive methods of local delivery and (2) the blood-brain…”
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S100A8/A9 predicts response to PIM kinase and PD-1/PD-L1 inhibition in triple-negative breast cancer mouse models by Begg, Lauren R., Orriols, Adrienne M., Zannikou, Markella, Yeh, Chen, Vadlamani, Pranathi, Kanojia, Deepak, Bolin, Rosemary, Dunne, Sara F., Balakrishnan, Sanjeev, Camarda, Roman, Roth, Diane, Zielinski-Mozny, Nicolette A., Yau, Christina, Vassilopoulos, Athanassios, Huang, Tzu-Hsuan, Kim, Kwang-Youn A., Horiuchi, Dai

“…Background Understanding why some triple-negative breast cancer (TNBC) patients respond poorly to existing therapies while others respond well remains a…”
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Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model by Rincón, Esther, Cejalvo, Teresa, Kanojia, Deepak, Alfranca, Arantzazu, Rodríguez-Milla, Miguel Ángel, Hoyos, Raul Andrés Gil, Han, Yu, Zhang, Lingjiao, Alemany, Ramón, Lesniak, Maciej S., García-Castro, Javier

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A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model by Kim, Julius W., Miska, Jason, Young, Jacob S., Rashidi, Aida, Kane, J. Robert, Panek, Wojciech K., Kanojia, Deepak, Han, Yu, Balyasnikova, Irina V., Lesniak, Maciej S.

“…Oncolytic virotherapy is a treatment approach with increasing clinical relevance, as indicated by the marked survival benefit seen in animal models and its…”
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Landscape of combination therapy trials in breast cancer brain metastasis by Fares, Jawad, Kanojia, Deepak, Rashidi, Aida, Ulasov, Ilya, Lesniak, Maciej S.

“…Combination therapy has become a cornerstone in cancer treatment to potentiate therapeutic effectiveness and overcome drug resistance and metastasis. In this…”
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CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells by Chang, Alan L, Miska, Jason, Wainwright, Derek A, Dey, Mahua, Rivetta, Claudia V, Yu, Dou, Kanojia, Deepak, Pituch, Katarzyna C, Qiao, Jian, Pytel, Peter, Han, Yu, Wu, Meijing, Zhang, Lingjiao, Horbinski, Craig M, Ahmed, Atique U, Lesniak, Maciej S

“…In many aggressive cancers, such as glioblastoma multiforme, progression is enabled by local immunosuppression driven by the accumulation of regulatory T cells…”
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Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma by Zhang, Peng, Miska, Jason, Lee-Chang, Catalina, Rashidi, Aida, Panek, Wojciech K., An, Shejuan, Zannikou, Markella, Lopez-Rosas, Aurora, Han, Yu, Xiao, Ting, Pituch, Katarzyna C., Kanojia, Deepak, Balyasnikova, Irina V., Lesniak, Maciej S.

“…Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to…”
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Repurposing autophagy regulators in brain tumors by Petrosyan, Edgar, Fares, Jawad, Cordero, Alex, Rashidi, Aida, Arrieta, Víctor A., Kanojia, Deepak, Lesniak, Maciej S.

“…Malignant brain tumors, such as glioblastoma multiforme (GBM) and brain metastases, continue to be an unmet medical challenge. Despite advances in cancer…”
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The Network of Cytokines in Brain Metastases by Fares, Jawad, Cordero, Alex, Kanojia, Deepak, Lesniak, Maciej S

“…Brain metastases are the most common of all intracranial tumors and a major cause of death in patients with cancer. Cytokines, including chemokines,…”
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4-Nitroquinoline-1-oxide induced experimental oral carcinogenesis by Kanojia, Deepak, Vaidya, Milind M.

“…Human oral cancer is the sixth largest group of malignancies worldwide and single largest group of malignancies in the Indian subcontinent. Seventy percent of…”
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Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma by Cheng, Shih-Hsun, Yu, Dou, Tsai, Hsiu-Ming, Morshed, Ramin A, Kanojia, Deepak, Lo, Leu-Wei, Leoni, Lara, Govind, Yureve, Zhang, Lingjiao, Aboody, Karen S, Lesniak, Maciej S, Chen, Chin-Tu, Balyasnikova, Irina V

“…There is strong clinical interest in using neural stem cells (NSCs) as carriers for targeted delivery of therapeutics to glioblastoma. Multimodal dynamic in…”
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EXTH-16. RATIONAL DESIGN OF COMBINATION THERAPY AGAINST HER2+ BRAIN METASTASES OF BREAST CANCER USING JQ-1 AND VINORELBINE by Panek, Wojciech K, Kanojia, Deepak, Xiao, Annie, Lesniak, Maciej S

“…Brain metastasis is a late complication of breast cancer progression and portends poor survival, in part due to an absence of targeted therapies. Our previous…”
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Abstract 1907: MYTX-011: A pH-dependent anti-cMET ADC with increased payload delivery in vivo and potent activity against cMET-expressing tumors of various epithelial origins by Kanojia, Deepak, Comb, William, Israelsen, William, Colombo, Federico, Nie, Lin, Gera, Nimish, Chittenden, Thomas, Fiske, Brian

“…Abstract cMET is an oncogenic receptor tyrosine kinase overexpressed in multiple types of solid tumors, including non-small cell lung cancer (NSCLC), gastric,…”
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CD49f and CD61 identify Her2 neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling by Lo, P-K, Kanojia, D, Liu, X, Singh, U P, Berger, F G, Wang, Q, Chen, H

“…Human epidermal growth factor receptor 2 (HER2)/Neu is overexpressed in 20–30% of breast cancers and associated with aggressive phenotypes and poor prognosis…”
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