Search Results - "Kanoh, Hirotaka"

Homeostatic and pathogenic roles of the GM3 ganglioside by Inokuchi, Jin‐ichi, Kanoh, Hirotaka, Inamori, Kei‐ichiro, Nagafuku, Masakazu, Nitta, Takahiro, Fukase, Koichi

“…Two decades ago, we achieved molecular cloning of ganglioside GM3 synthase (GM3S; ST3GAL5), the enzyme responsible for initiating biosynthesis of complex…”
Get full text

Globo-series glycosphingolipids enhance Toll-like receptor 4-mediated inflammation and play a pathophysiological role in diabetic nephropathy by Nitta, Takahiro, Kanoh, Hirotaka, Inamori, Kei-ichiro, Suzuki, Akemi, Takahashi, Tomoko, Inokuchi, Jin-ichi

“…Abstract Alteration of glycosphingolipid (GSL) expression plays key roles in the pathogenesis and pathophysiology of many important human diseases, including…”
Get full text

Dual comprehensive approach to decipher the Drosophila Toll pathway, ex vivo RNAi screenings and immunoprecipitation-mass spectrometry by Kanoh, Hirotaka, Kato, Hiroyuki, Suda, Yamato, Hori, Aki, Kurata, Shoichiro, Kuraishi, Takayuki

“…The Drosophila Toll pathway is involved in embryonic development, innate immunity, and cell-cell interactions. However, compared to the mammalian Toll-like…”
Get full text

Pathophysiological Significance of GM3 Ganglioside Molecular Species With a Particular Attention to the Metabolic Syndrome Focusing on Toll-Like Receptor 4 Binding by Inokuchi, Jin-ichi, Kanoh, Hirotaka

“…GM3 ganglioside, the first molecule in ganglioside family biosynthesis, is formed by transfer of sialic acid to lactosylceramide. Several dozen GM3 molecular…”
Get full text

Dietary gangliosides rescue GM3 synthase deficiency outcomes in mice accompanied by neurogenesis in the hippocampus by Inokuchi, Jin-Ichi, Go, Shinji, Suzuki, Akemi, Nakagawasai, Osamu, Odaira-Satoh, Takayo, Veillon, Lucas, Nitta, Takahiro, McJarrow, Paul, Kanoh, Hirotaka, Inamori, Kei-Ichiro, Tan-No, Koichi, Collett, Michael

“…Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3SD) causes an absence of GM3 and all…”
Get full text

Serum GM3(d18:1-16:0) and GM3(d18:1-24:1) levels may be associated with lymphoma: An exploratory study with haematological diseases by Nishikawa, Masako, Kurano, Makoto, Nitta, Takahiro, Kanoh, Hirotaka, Inokuchi, Jin-ichi, Yatomi, Yutaka

“…GM3 (monosialodihexosylganglioside) is a type of ganglioside, which is a molecule composed of ceramide and oligosaccharide containing one or more sialic acids…”
Get full text

NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains by Nihei, Wataru, Nagafuku, Masakazu, Hayamizu, Hirotaka, Odagiri, Yuta, Tamura, Yumi, Kikuchi, Yui, Veillon, Lucas, Kanoh, Hirotaka, Inamori, Kei-ichiro, Arai, Kenta, Kabayama, Kazuya, Fukase, Koichi, Inokuchi, Jin-ichi

“…Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to…”
Get full text

内因性リガンドによるToll様受容体制御と慢性炎症疾患への関与の解明─ガングリオシドによるTLR4シグナルの恒常性維持と破綻のメカニズム by 狩野, 裕考

“…「はじめに」ガングリオシドを始めとするスフィンゴ糖脂質は, 一般に, 細胞膜に含まれる機能性脂質として知られている. 細胞膜には, 細胞膜自体を構成する役割を持つリン脂質が多く含まれており, スフィンゴ糖脂質の相対的な存在比率は小さい. しかし, スフィンゴ糖脂質は,…”
Get full text

Ex vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract by Kanoh, Hirotaka, Kuraishi, Takayuki, Tong, Li-Li, Watanabe, Ryo, Nagata, Shinji, Kurata, Shoichiro

“…Damage-associated molecular patterns (DAMPs), so-called “danger signals,” play important roles in host defense and pathophysiology in mammals and insects. In…”
Get full text

A Receptor Guanylate Cyclase, Gyc76C, Mediates Humoral, and Cellular Responses in Distinct Ways in Drosophila Immunity by Iwashita, Shinzo, Suzuki, Hiroaki, Goto, Akira, Oyama, Tomohito, Kanoh, Hirotaka, Kuraishi, Takayuki, Fuse, Naoyuki, Yano, Tamaki, Oshima, Yoshiteru, Dow, Julian A T, Davies, Shireen-Anne, Kurata, Shoichiro

“…Innate immunity is an evolutionarily conserved host defense system against infections. The fruit fly relies solely on innate immunity for infection defense,…”
Get full text

cGMP signaling pathway that modulates NF-κB activation in innate immune responses by Kanoh, Hirotaka, Iwashita, Shinzo, Kuraishi, Takayuki, Goto, Akira, Fuse, Naoyuki, Ueno, Haruna, Nimura, Mariko, Oyama, Tomohito, Tang, Chang, Watanabe, Ryo, Hori, Aki, Momiuchi, Yoshiki, Ishikawa, Hiroki, Suzuki, Hiroaki, Nabe, Kumiko, Takagaki, Takeshi, Fukuzaki, Masataka, Tong, Li-Li, Yamada, Sinya, Oshima, Yoshiteru, Aigaki, Toshiro, Dow, Julian A.T., Davies, Shireen-Anne, Kurata, Shoichiro

“…The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation…”
Get full text

Homeostatic and Pathophysiological Regulation of Toll-like Receptor 4 Signaling by GM3 Ganglioside Molecular Species by Kanoh, Hirotaka

“…Chronic inflammation plays an important role in the pathogenesis of obesity and metabolic disorders. In obesity, pattern-recognition receptors in innate immune…”
Get full text

De Novo Glycan Display on Cell Surfaces Using HaloTag: Visualizing the Effect of the Galectin Lattice on the Lateral Diffusion and Extracellular Vesicle Loading of Glycosylated Membrane Proteins by Miura, Ayane, Manabe, Yoshiyuki, Suzuki, Kenichi G. N., Shomura, Hiroki, Okamura, Soichiro, Shirakawa, Asuka, Yano, Kumpei, Miyake, Shuto, Mayusumi, Koki, Lin, Chun-Cheng, Morimoto, Kenta, Ishitobi, Jojiro, Nakase, Ikuhiko, Arai, Kenta, Kobayashi, Shouhei, Ishikawa, Ushio, Kanoh, Hirotaka, Miyoshi, Eiji, Yamaji, Toshiyuki, Kabayama, Kazuya, Fukase, Koichi

“…Glycans cover the cell surface to form the glycocalyx, which governs a myriad of biological phenomena. However, understanding and regulating glycan functions…”
Get full text

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion by Kofuji, Satoshi, Wolfe, Kara, Sumita, Kazutaka, Kageyama, Shun, Yoshino, Hirofumi, Hirota, Yoshihisa, Ogawa-Iio, Aki, Kanoh, Hirotaka, Sasaki, Mika, Kofuji, Kaori, Davis, Mindy I., Pragani, Rajan, Shen, Min, Boxer, Matthew B., Nakatsu, Fubito, Nigorikawa, Kiyomi, Sasaki, Takehiko, Takeuchi, Koh, Senda, Toshiya, Kim, Seong M., Edinger, Aimee L., Simeonov, Anton, Sasaki, Atsuo T.

“…In animal cells, vacuoles are absent, but can be induced by diseases and drugs. While phosphoinositides are critical for membrane trafficking, their role in…”
Get full text

Perioperative changes in ganglioside monosialodihexosylganglioside (GM3) molecular species for benign prostatic hyperplasia: a preliminary report by Anan, Go, Nitta, Takahiro, Kanoh, Hirotaka, Sato, Makoto, Inokuchi, Jin-Ichi

“…Benign prostatic hyperplasia (BPH) progresses with age and is associated with chronic inflammation. We focused on the relationship between BPH and ganglioside…”
Get full text

Chronic encephalomyelitis virus exhibits cellular tropism and evades pDCs by binding to sialylated integrins as the cell surface receptors by Takeda, Kazuya, Kaifu, Tomonori, Michihata, Ryunosuke, Kinugawa, Naotaka, Fujioka, Atushi, Tateno, Ayaka, Toshima, Kaoru, Kanoh, Hirotaka, Inamori, Kei‐Ichiro, Kamijo, Keiju, Himeda, Toshiki, Ohara, Yoshiro, Inokuchi, Jin‐Ichi, Nakamura, Akira

“…Theiler's murine encephalomyelitis virus (TMEV) causes a chronic demyelinating disease similar to multiple sclerosis in mice. Although sialic acids have been…”
Get full text

Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity by Kanoh, Hirotaka, Nitta, Takahiro, Go, Shinji, Inamori, Kei‐ichiro, Veillon, Lucas, Nihei, Wataru, Fujii, Mayu, Kabayama, Kazuya, Shimoyama, Atsushi, Fukase, Koichi, Ohto, Umeharu, Shimizu, Toshiyuki, Watanabe, Taku, Shindo, Hiroki, Aoki, Sorama, Sato, Kenichi, Nagasaki, Mika, Yatomi, Yutaka, Komura, Naoko, Ando, Hiromune, Ishida, Hideharu, Kiso, Makoto, Natori, Yoshihiro, Yoshimura, Yuichi, Zonca, Asia, Cattaneo, Anna, Letizia, Marilena, Ciampa, Maria, Mauri, Laura, Prinetti, Alessandro, Sonnino, Sandro, Suzuki, Akemi, Inokuchi, Jin‐ichi

“…Innate immune signaling via TLR4 plays critical roles in pathogenesis of metabolic disorders, but the contribution of different lipid species to metabolic…”
Get full text

Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults by Kanoh, Hirotaka, Tong, Li-Li, Kuraishi, Takayuki, Suda, Yamato, Momiuchi, Yoshiki, Shishido, Fumi, Kurata, Shoichiro

“…The Drosophila Toll pathway plays important roles in innate immune responses against Gram-positive bacteria and fungi. To identify previously uncharacterized…”
Get more information

Biology of GM3 Ganglioside by Inokuchi, Jin-Ichi, Inamori, Kei-Ichiro, Kabayama, Kazuya, Nagafuku, Masakazu, Uemura, Satoshi, Go, Shinji, Suzuki, Akemi, Ohno, Isao, Kanoh, Hirotaka, Shishido, Fumi

“…Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides,…”
Get full text

Homeostatic and pathogenic roles of GM 3 ganglioside molecular species in TLR 4 signaling in obesity by Kanoh, Hirotaka, Nitta, Takahiro, Go, Shinji, Inamori, Kei‐ichiro, Veillon, Lucas, Nihei, Wataru, Fujii, Mayu, Kabayama, Kazuya, Shimoyama, Atsushi, Fukase, Koichi, Ohto, Umeharu, Shimizu, Toshiyuki, Watanabe, Taku, Shindo, Hiroki, Aoki, Sorama, Sato, Kenichi, Nagasaki, Mika, Yatomi, Yutaka, Komura, Naoko, Ando, Hiromune, Ishida, Hideharu, Kiso, Makoto, Natori, Yoshihiro, Yoshimura, Yuichi, Zonca, Asia, Cattaneo, Anna, Letizia, Marilena, Ciampa, Maria, Mauri, Laura, Prinetti, Alessandro, Sonnino, Sandro, Suzuki, Akemi, Inokuchi, Jin‐ichi

Get full text