Search Results - "Kano, Taichi"

Asymmetric Synthesis of Chiral Sulfimides through the O‐Alkylation of Enantioenriched Sulfinamides and Addition of Carbon Nucleophiles by Tsuzuki, Saori, Kano, Taichi

“…Chiral sulfimides, the aza‐analogues of sulfoxides, are valuable compounds in organic synthesis and medicinal chemistry. Herein, we report an efficient method…”
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Cu-Catalyzed Enantioselective Alkylarylation of Vinylarenes Enabled by Chiral Binaphthyl–BOX Hybrid Ligands by Sakurai, Shunya, Matsumoto, Akira, Kano, Taichi, Maruoka, Keiji

“…Transition-metal-catalyzed radical relay coupling reactions have recently emerged as one of the most powerful methods to achieve difunctionalization of…”
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Diethylzinc‐Mediated Cross‐Coupling Reactions between Dibromoketones and Monobromo Carbonyl Compounds by Takeshima, Aika, Kano, Taichi

“…A novel route to synthesize 1,4‐dicarbonyl compounds is described. α,α‐Dibromoketones generate zinc enolates through a diethylzinc‐mediated halogen‐metal…”
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Efficient Synthesis of Cyclic Sulfoximines from N‐Propargylsulfinamides through Sulfur–Carbon Bond Formation by Aota, Yusuke, Maeda, Yoshiaki, Kano, Taichi, Maruoka, Keiji

“…Cyclic sulfoximines were readily synthesized by the cyclization of N‐propargylsulfinamides without using expensive and toxic metal catalysts. This cyclization…”
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Stereocontrolled Synthesis of Vicinal Diamines by Organocatalytic Asymmetric Mannich Reaction of N-Protected Aminoacetaldehydes: Formal Synthesis of (−)-Agelastatin A by Kano, Taichi, Sakamoto, Ryu, Akakura, Matsujiro, Maruoka, Keiji

“…The 1,2-diamine (vicinal diamine) motif is present in a number of natural products with interesting biological activity and in many chiral molecular catalysts…”
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Construction of Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 3‐Arylpiperidin‐2‐ones Under Phase‐Transfer Conditions by Inukai, Tomoaki, Kano, Taichi, Maruoka, Keiji

“…A highly enantioselective synthesis of δ‐lactams having a chiral quaternary carbon center at the α‐position has been developed through an asymmetric alkylation…”
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Versatile In Situ Generated N-Boc-Imines: Application to Phase-Transfer-Catalyzed Asymmetric Mannich-Type Reactions by Kano, Taichi, Kobayashi, Ryohei, Maruoka, Keiji

“…The efficient construction of nitrogen‐containing organic compounds is a major challenge in chemical synthesis. Imines are one of the most important classes of…”
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One-Pot Synthesis of Less Accessible N‑Boc-Propargylic Amines through BF3‑Catalyzed Alkynylation and Allylation Using Boronic Esters by Yasumoto, Kento, Kano, Taichi, Maruoka, Keiji

“…An efficient synthesis of α-alkynyl- or α-allyl-substituted N-Boc-propargylic amines is described via an alkynylation or allylation of alkynyl-substituted…”
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Practical Asymmetric Synthesis of Chiral Sulfoximines via Sulfur-Selective Alkylation by Maeda, Yoshiaki, Hamada, Suguru, Aota, Yusuke, Otsubo, Kazuya, Kano, Taichi, Maruoka, Keiji

“…Chiral sulfoximines have recently been considered as promising bioisosteres in medicinal chemistry. However, methods for preparing chiral sulfoximines in a…”
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Construction of a Chiral Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 2‑Arylcyclohexanones under Phase-Transfer Conditions by Kano, Taichi, Hayashi, Yumi, Maruoka, Keiji

“…In this paper, we present an asymmetric alkylation of modified 2-arylcyclohexanones that employs a novel chiral ammonium bromide as a phase-transfer catalyst…”
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Organocatalytic Formal (3 + 2) Cycloaddition toward Chiral Pyrrolo[1,2‑a]indoles via Dynamic Kinetic Resolution of Allene Intermediates by Bai, Jian-Fei, Zhao, Lulu, Wang, Fang, Yan, Fachao, Kano, Taichi, Maruoka, Keiji, Li, Yuehui

“…We report the chiral phosphoric acid catalyzed formal (3 + 2) cycloaddition of 3-substituted 1H-indoles and propargylic alcohols containing a functional…”
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Acid-Catalyzed In Situ Generation of Less Accessible or Unprecedented N-Boc Imines from N-Boc Aminals by Kano, Taichi, Yurino, Taiga, Asakawa, Daisuke, Maruoka, Keiji

“…Crafty aminals: The in situ generation of hitherto unattainable alkynyl‐substituted N‐Boc‐protected imines was realized by the acid‐catalyzed elimination of…”
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A Designer Axially Chiral Amino Sulfonamide as an Efficient Organocatalyst for Direct Asymmetric anti‐Selective Mannich Reactions and syn‐Selective Cross‐Aldol Reactions by Kano, Taichi, Yamaguchi, Yukako, Maruoka, Keiji

“…Amino sulfonamide catalyst: A distal proton of the axially chiral amino sulfonamide (S)‐1 realized the opposite diastereoselectivity in Mannich and cross‐aldol…”
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Designer Axially Chiral Amino Sulfonamide as an Efficient Organocatalyst for Direct Asymmetric Mannich Reactions of N-Boc-Protected Imines by Kano, Taichi, Yamaguchi, Yukako, Maruoka, Keiji

“…The moderate nucleophilicity of the axially chiral amino sulfonamide (S)-1 suppresses the problematic side reactions, including aldol reactions, in the…”
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N-Boc-aminals as easily accessible precursors for less accessible N-Boc-imines: facile synthesis of optically active propargylamine derivatives using Mannich-type reactions by Yurino, Taiga, Aota, Yusuke, Asakawa, Daisuke, Kano, Taichi, Maruoka, Keiji

“…We developed a facile and practical synthesis of N-Boc-aminals, which can be used as precursors for less accessible N-Boc-imines. Aminals were obtained via…”
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Metal-Free Direct Asymmetric Aminoxylation of Aldehydes Catalyzed by a Binaphthyl-Based Chiral Amine by Kano, Taichi, Mii, Haruka, Maruoka, Keiji

“…And I'm free, metal‐free fallin': A metal‐free direct asymmetric aminoxylation of aldehydes with the oxoammonium salt 1, generated in situ from TEMPO and…”
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Catalyst‐Controlled, Enantioselective, and Diastereodivergent Conjugate Addition of Aldehydes to Electron‐Deficient Olefins by Kan, S. B. Jennifer, Maruyama, Hiroki, Akakura, Matsujiro, Kano, Taichi, Maruoka, Keiji

“…A chiral‐amine‐catalyzed enantioselective and diastereodivergent method for aldehyde addition to electron‐deficient olefins is presented. Hydrogen bonding was…”
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Design of chiral bifunctional secondary amine catalysts for asymmetric enamine catalysis by Kano, Taichi, Maruoka, Keiji

“…A series of binaphthyl-based secondary amine catalysts containing various functional groups have been designed as new chiral bifunctional amine catalysts…”
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syn-Selective and Enantioselective Direct Cross-Aldol Reactions between Aldehydes Catalyzed by an Axially Chiral Amino Sulfonamide by Kano, Taichi, Yamaguchi, Yukako, Tanaka, Youhei, Maruoka, Keiji

“…Complementary to proline: An axially chiral amino sulfonamide (S)‐1 was successfully applied as the catalyst to the direct cross‐aldol reaction between two…”
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Rate Acceleration of Solid-Liquid Phase-Transfer Catalysis by Rotor-Stator Homogenizer by Kano, Taichi, Aota, Yusuke, Maruoka, Keiji

“…A rotor‐stator homogenizer was found to be an effective mixing tool that accelerated solid‐liquid phase‐transfer reactions. In the asymmetric alkylation under…”
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