Search Results - "Kannangara, Timal S"

NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice by Eadie, Brennan D., Cushman, Jesse, Kannangara, Timal S., Fanselow, Michael S., Christie, Brian R.

“…Fragile X syndrome (FXS) is the most common form of inherited intellectual disability in humans. This X‐linked disorder is caused by the transcriptional…”
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GluN2A-/- Mice Lack Bidirectional Synaptic Plasticity in the Dentate Gyrus and Perform Poorly on Spatial Pattern Separation Tasks by Kannangara, Timal S, Eadie, Brennan D, Bostrom, Crystal A, Morch, Kristin, Brocardo, Patricia S, Christie, Brian R

“…The different secondary subunits of the N-methyl-d-aspartate (NMDA) receptor each convey unique biophysical properties to the receptor complex, and may be key…”
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Deletion of the NMDA receptor GluN2A subunit significantly decreases dendritic growth in maturing dentate granule neurons by Kannangara, Timal S, Bostrom, Crystal A, Ratzlaff, Andrea, Thompson, Lee, Cater, Robyn M, Gil-Mohapel, Joana, Christie, Brian R

“…It is known that NMDA receptors can modulate adult hippocampal neurogenesis, but the contribution of specific regulatory GluN2 subunits has been difficult to…”
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Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampus by Dahlhaus, Regina, Hines, Rochelle M., Eadie, Brennan D., Kannangara, Timal S., Hines, Dustin J., Brown, Craig E., Christie, Brian R., El-Husseini, Alaa

“…Trans‐synaptic cell‐adhesion molecules have been implicated in regulating CNS synaptogenesis. Among these, the Neuroligin (NL) family (NLs 1–4) of postsynaptic…”
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Excitable Adult-Generated GABAergic Neurons Acquire Functional Innervation in the Cortex after Stroke by Kannangara, Timal S., Carter, Anthony, Xue, Yingben, Dhaliwal, Jagroop S., Béïque, Jean-Claude, Lagace, Diane C.

“…Ischemic stroke enhances the proliferation of adult-generated precursor cells that ectopically migrate toward the infarct. Studies have correlated precursor…”
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The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery by Gouveia, Ayden, Seegobin, Matthew, Kannangara, Timal S., He, Ling, Wondisford, Fredric, Comin, Cesar H., Costa, Luciano da F., Béïque, Jean-Claude, Lagace, Diane C., Lacoste, Baptiste, Wang, Jing

“…Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity. Since…”
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Exercising Our Brains: How Physical Activity Impacts Synaptic Plasticity in the Dentate Gyrus by Christie, Brian R., Eadie, Brennan D., Kannangara, Timal S., Robillard, Julie M., Shin, James, Titterness, Andrea K.

“…Exercise that engages the cardiovascular system has a myriad of effects on the body; however, we usually do not give much consideration to the benefits it may…”
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The Multi-pronged Regulation of Adult Neurogenesis by Forkhead Box O Family Members by Kannangara, Timal S., Lagace, Diane C.

“…In this issue of Neuron, Schäffner et al. (2018) discover multiple effects of the Forkhead Box O (FoxO) transcription factor family on the different stages of…”
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Delayed Treatment with Histone Deacetylase Inhibitors Promotes Stroke Recovery by Kannangara, Timal S, Vani, Marc A

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The muscles’ grip on neurogenesis: contributions of skeletal muscle‐derived vascular endothelial growth factor to running‐induced stem cell proliferation by Kannangara, Timal S., Vani, Marc A.

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Running reduces stress and enhances cell genesis in aged mice by Kannangara, Timal S, Lucero, Melanie J, Gil-Mohapel, Joana, Drapala, Robert J, Simpson, Jessica M, Christie, Brian R, van Praag, Henriette

“…Abstract Cell proliferation and neurogenesis are diminished in the aging mouse dentate gyrus. However, it is not known whether isolated or social living…”
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Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2 by Dhaliwal, Jagroop, Kannangara, Timal S., Vaculik, Michael, Xue, Yingben, Kumar, Keren L., Maione, Amanda, Béïque, Jean-Claude, Shen, Jie, Lagace, Diane C.

“…Mutations in the presenilin genes ( PS1 and PS2 ) are a major cause of familial-Alzheimer’s disease (FAD). Presenilins regulate neurogenesis in the developing…”
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Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1 by Parkinson, Pamela F, Kannangara, Timal S, Eadie, Brennan D, Burgess, Braydon L, Wellington, Cheryl L, Christie, Brian R

“…Cognitive deficits are a hallmark feature of both Down Syndrome (DS) and Alzheimer's Disease (AD). Extra copies of the genes on chromosome 21 may also play an…”
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Stress differentially regulates the effects of voluntary exercise on cell proliferation in the dentate gyrus of mice by Kannangara, Timal S., Webber, Alina, Gil-Mohapel, Joana, Christie, Brian R.

“…It has been well‐established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent…”
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GluN2A super(-/-) Mice Lack Bidirectional Synaptic Plasticity in the Dentate Gyrus and Perform Poorly on Spatial Pattern Separation Tasks by Kannangara, Timal S, Eadie, Brennan D, Bostrom, Crystal A, Morch, Kristin, Brocardo, Patricia S, Christie, Brian R

“…The different secondary subunits of the N-methyl-d-aspartate (NMDA) receptor each convey unique biophysical properties to the receptor complex, and may be key…”
Get full text