Search Results - "Kanki, P"

The Tol2kit: A multisite gateway‐based construction kit for Tol2 transposon transgenesis constructs by Kwan, Kristen M., Fujimoto, Esther, Grabher, Clemens, Mangum, Benjamin D., Hardy, Melissa E., Campbell, Douglas S., Parant, John M., Yost, H. Joseph, Kanki, John P., Chien, Chi‐Bin

“…Transgenesis is an important tool for assessing gene function. In zebrafish, transgenesis has suffered from three problems: the labor of building complex…”
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Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis by Zhu, Shizhen, Lee, Jeong-Soo, Guo, Feng, Shin, Jimann, Perez-Atayde, Antonio R., Kutok, Jeffery L., Rodig, Scott J., Neuberg, Donna S., Helman, Daniel, Feng, Hui, Stewart, Rodney A., Wang, Wenchao, George, Rani E., Kanki, John P., Look, A. Thomas

“…Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting…”
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Interplay of Pu.1 and Gata1 Determines Myelo-Erythroid Progenitor Cell Fate in Zebrafish by Rhodes, Jennifer, Hagen, Andreas, Hsu, Karl, Deng, Min, Liu, Ting Xi, Look, A.Thomas, Kanki, John P.

“…The zebrafish is a powerful model system for investigating embryonic vertebrate hematopoiesis, allowing for the critical in vivo analysis of cell lineage…”
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On semiparametric estimation of a path-specific effect in the presence of mediator-outcome confounding by Miles, C H, Shpitser, I, Kanki, P, Meloni, S, Tchetgen Tchetgen, E J

“…Summary Path-specific effects constitute a broad class of mediated effects from an exposure to an outcome via one or more causal pathways along a set of…”
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Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish by Rodríguez-Marí, Adriana, Wilson, Catherine, Titus, Tom A, Cañestro, Cristian, BreMiller, Ruth A, Yan, Yi-Lin, Nanda, Indrajit, Johnston, Adam, Kanki, John P, Gray, Erin M, He, Xinjun, Spitsbergen, Jan, Schindler, Detlev, Postlethwait, John H

“…Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate…”
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In vivo Tracking of T Cell Development, Ablation, and Engraftment in Transgenic Zebrafish by Langenau, David M., Ferrando, Adolfo A., Traver, David, Kutok, Jeffery L., Hezel, John-Paul D., Kanki, John P., Zon, Leonard I., Look, A. Thomas, Trede, Nikolaus S., Alt, Frederick W.

“…Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (lck) promoter were used to analyze critical aspects of the immune…”
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tp53 Mutant Zebrafish Develop Malignant Peripheral Nerve Sheath Tumors by Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Christopher D. M. Fletcher, Morris, John P., Liu, Ting Xi, Schulte-Merker, Stefan, Kanki, John P., Plasterk, Ronald, Zon, Leonard I., Look, A. Thomas, Vogelstein, Bert

“…TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further…”
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Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3 by Sidi, Samuel, Sanda, Takaomi, Kennedy, Richard D., Hagen, Andreas T., Jette, Cicely A., Hoffmans, Raymond, Pascual, Jennifer, Imamura, Shintaro, Kishi, Shuji, Amatruda, James F., Kanki, John P., Green, Douglas R., D'Andrea, Alan A., Look, A. Thomas

“…Evasion of DNA damage-induced cell death, via mutation of the p53 tumor suppressor or overexpression of prosurvival Bcl-2 family proteins, is a key step toward…”
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Cre/Lox-Regulated Transgenic Zebrafish Model with Conditional Myc-Induced T Cell Acute Lymphoblastic Leukemia by Langenau, David M., Feng, Hui, Berghmans, Stephane, Kanki, John P., Kutok, Jeffery L., Look, A. Thomas, Cooper, Max D.

“…We have created a stable transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled T cell acute lymphoblastic leukemia (T-ALL), allowing visualization…”
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Myc-Induced T Cell Leukemia in Transgenic Zebrafish by Langenau, David M., Traver, David, Ferrando, Adolfo A., Kutok, Jeffery L., Aster, Jon C., Kanki, John P., Lin, Shuo, Prochownik, Ed, Trede, Nikolaus S., Zon, Leonard I., Look, A. Thomas

“…The zebrafish is an attractive model organism for studying cancer development because of its genetic accessibility. Here we describe the induction of clonally…”
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Myelopoiesis in the zebrafish, Danio rerio by Bennett, Carolyn M., Kanki, John P., Rhodes, Jennifer, Liu, Ting X., Paw, Barry H., Kieran, Mark W., Langenau, David M., Delahaye-Brown, Anne, Zon, Leonard I., Fleming, Mark D., Look, A. Thomas

“…Genome-wide chemical mutagenesis screens in the zebrafish(Danio rerio) have led to the identification of novel genes affecting vertebrate erythropoiesis. In…”
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Zebrafish foxd3 is selectively required for neural crest specification, migration and survival by Stewart, Rodney A., Arduini, Brigitte L., Berghmans, Stephane, George, Rani E., Kanki, John P., Henion, Paul D., Look, A. Thomas

“…The vertebrate neural crest is a pluripotent cell population that generates a large variety of cell types, including peripheral neurons, cartilage and pigment…”
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Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish by Bolli, Niccolò, Payne, Elspeth M., Grabher, Clemens, Lee, Jeong-Soo, Johnston, Adam B., Falini, Brunangelo, Kanki, John P., Look, A. Thomas

“…Mutations in the human nucleophosmin (NPM1) gene are the most frequent genetic alteration in adult acute myeloid leukemias (AMLs) and result in aberrant…”
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Making waves in cancer research: new models in the zebrafish by Berghmans, Stephane, Jette, Cicely, Langenau, David, Hsu, Karl, Stewart, Rodney, Look, Thomas, Kanki, John P

“…The zebrafish (Danio rerio) has proven to be a powerful vertebrate model system for the genetic analysis of developmental pathways and is only beginning to be…”
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Live imaging of chronic inflammation caused by mutation of zebrafish Hai1 by Mathias, Jonathan R, Dodd, M Ernest, Walters, Kevin B, Rhodes, Jennifer, Kanki, John P, Look, A Thomas, Huttenlocher, Anna

“…The hallmark of chronic inflammation is the infiltration and persistence of leukocytes within inflamed tissue. Here, we describe the first zebrafish chronic…”
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Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb by Grabher, C, Payne, E M, Johnston, A B, Bolli, N, Lechman, E, Dick, J E, Kanki, J P, Look, A T

“…Precise regulatory mechanisms are required to appropriately modulate the cellular levels of transcription factors controlling cell fate decisions during blood…”
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Patients who present late to HIV care and associated risk factors in Nigeria by Agaba, PA, Meloni, ST, Sule, HM, Agbaji, OO, Ekeh, PN, Job, GC, Nyango, N, Ugoagwu, PO, Imade, GE, Idoko, JA, Kanki, PJ

“…Objectives Our objectives were to assess trends in late presentation and advanced HIV disease (AHD) and determine associated risk factors. Methods We conducted…”
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Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development by Shin, Jimann, Padmanabhan, Arun, de Groh, Eric D, Lee, Jeong-Soo, Haidar, Sam, Dahlberg, Suzanne, Guo, Feng, He, Shuning, Wolman, Marc A, Granato, Michael, Lawson, Nathan D, Wolfe, Scot A, Kim, Seok-Hyung, Solnica-Krezel, Lilianna, Kanki, John P, Ligon, Keith L, Epstein, Jonathan A, Look, A Thomas

“…Neurofibromatosis type 1 (NF1) is a common, dominantly inherited genetic disorder that results from mutations in the neurofibromin 1 (NF1) gene. Affected…”
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Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression by Anderson, Heidi, Patch, Taylor C., Reddy, Pavankumar N.G., Hagedorn, Elliott J., Kim, Peter G., Soltis, Kathleen A., Chen, Michael J., Tamplin, Owen J., Frye, Maike, MacLean, Glenn A., Hübner, Kathleen, Bauer, Daniel E., Kanki, John P., Vogin, Guillaume, Huston, Nicholas C., Nguyen, Minh, Fujiwara, Yuko, Paw, Barry H., Vestweber, Dietmar, Zon, Leonard I., Orkin, Stuart H., Daley, George Q., Shah, Dhvanit I.

“…Rare endothelial cells in the aorta-gonad-mesonephros (AGM) transition into hematopoietic stem cells (HSCs) during embryonic development. Lineage tracing…”
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NOTCH1-induced T-cell leukemia in transgenic zebrafish by CHEN, J, JETTE, C, KANKI, J. P, ASTER, J. C, LOOK, A. T, GRIFFIN, J. D

“…Activating mutations in the NOTCH1 gene have been found in about 60% of patients with T-cell acute lymphoblastic leukemia (T-ALL). In order to study the…”
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