Search Results - "Kanke, T"

Novel antagonists for proteinase‐activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo by Kanke, T, Kabeya, M, Kubo, S, Kondo, S, Yasuoka, K, Tagashira, J, Ishiwata, H, Saka, M, Furuyama, T, Nishiyama, T, Doi, T, Hattori, Y, Kawabata, A, Cunningham, MR, Plevin, R

“…Background and purpose:  Proteinase‐activated receptor 2 (PAR2) is a G‐protein coupled receptor associated with many pathophysiological functions. To date, the…”
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Cytokine upregulation of proteinase‐activated‐receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase β in human endothelial cells by Ritchie, E, Saka, M, MacKenzie, C, Drummond, R, Wheeler‐Jones, C, Kanke, T, Plevin, R

“…Background and purpose: Up‐regulation of proteinase‐activated receptor‐2 (PAR2) is a factor in a number of disease states and we have therefore examined the…”
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Effects of adenosine on adhesion molecule expression and cytokine production in human PBMC depend on the receptor subtype activated by Takahashi, H K, Iwagaki, H, Hamano, R, Wake, H, Kanke, T, Liu, K, Yoshino, T, Tanaka, N, Nishibori, M

“…Background and purpose: Adenosine suppresses immune responses through adenosine2A (A2A) receptors, by raising intracellular cAMP. Interleukin (IL)‐18…”
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Follicle Growth and Oocyte Developmental Competence in Cows With Liver Damage by Iwata, H, Tanaka, H, Kanke, T, Sakaguchi, Y, Shibano, K, Kuwayama, T, Monji, Y

“…Follicle growth, oocyte quality or oocyte growing environment (follicular fluid) were evaluated in cows with severe liver damage (haemorrhage, telangiectasis,…”
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Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats by Liu, Keyue, Mori, Shuji, Takahashi, Hideo K, Tomono, Yasuko, Wake, Hidenori, Kanke, Toru, Sato, Yasuharu, Hiraga, Norihito, Adachi, Naoto, Yoshino, Tadashi, Nishibori, Masahiro

“…The high mobility group box-1 (HMGB1), originally identified as an architectural nuclear protein, exhibits an inflammatory cytokine-like activity in the…”
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Proteinase-Activated Receptors by Macfarlane, S R, Seatter, M J, Kanke, T, Hunter, G D, Plevin, R

“…Proteinase-activated receptors are a recently described, novel family of seven-transmembrane G-protein-coupled receptors. Rather then being stimulated through…”
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Essential role for proteinase-activated receptor-2 in arthritis by Ferrell, William R., Lockhart, John C., Kelso, Elizabeth B., Dunning, Lynette, Plevin, Robin, Meek, Stephen E., Smith, Andrew J.H., Hunter, Gary D., McLean, John S., McGarry, Frances, Ramage, Robert, Jiang, Lu, Kanke, Toru, Kawagoe, Junichi

“…Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in…”
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The role of intracellular Ca2+ in the regulation of proteinase‐activated receptor‐2 mediated nuclear factor kappa B signalling in keratinocytes by Macfarlane, Scott R, Sloss, Callum M, Cameron, Pamela, Kanke, Toru, McKenzie, Roderick C, Plevin, Robin

“…1 In this study, we examined the role of Ca2+ in linking proteinase‐activated receptor‐2 (PAR2) to the nuclear factor kappa B (NFκB) pathway in a skin…”
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Suppression of pancreatitis‐related allodynia/hyperalgesia by proteinase‐activated receptor‐2 in mice by Kawabata, Atsufumi, Matsunami, Maho, Tsutsumi, Masahiro, Ishiki, Tsuyoshi, Fukushima, Osamu, Sekiguchi, Fumiko, Kawao, Naoyuki, Minami, Takeshi, Kanke, Toru, Saito, Naohiro

“…1 Proteinase‐activated receptor‐2 (PAR2), a receptor activated by trypsin and tryptase, is abundantly expressed in the gastrointestinal tract including the…”
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Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes by Kanke, T, Macfarlane, S R, Seatter, M J, Davenport, E, Paul, A, McKenzie, R C, Plevin, R

“…In this study we examined the regulation of the stress-activated protein (SAP) kinases and inhibitory kappa B kinases (IKKs) through stimulation of the novel…”
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Potent and metabolically stable agonists for protease-activated receptor-2: evaluation of activity in multiple assay systems in vitro and in vivo by Kawabata, Atsufumi, Kanke, Toru, Yonezawa, Daiki, Ishiki, Tsuyoshi, Saka, Masako, Kabeya, Mototsugu, Sekiguchi, Fumiko, Kubo, Satoko, Kuroda, Ryotaro, Iwaki, Masahiro, Katsura, Kousaku, Plevin, Robin

“…To develop potent and metabolically stable agonists for protease-activated receptor-2 (PAR-2), we prepared 2-furoylated (2f) derivatives of native…”
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Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: Involvement of endogenous bradykinin by Kawabata, Atsufumi, Kawao, Naoyuki, Kitano, Tomoko, Matsunami, Maho, Satoh, Reiko, Ishiki, Tsuyoshi, Masuko, Takashi, Kanke, Toru, Saito, Naohiro

“…Intracolonic (i.col.) administration of the PAR2-activating peptide (PAR2AP) SLIGRL-NH 2 slowly develops visceral hypersensitivity to i.col. capsaicin in ddY…”
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Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase [beta] in human endothelial cells by Ritchie, E, Saka, M, MacKenzie, C, Drummond, R, Wheeler-Jones, C, Kanke, T, Plevin, R

“…BACKGROUND AND PURPOSE: Up-regulation of proteinase-activated receptor-2 (PAR2) is a factor in a number of disease states and we have therefore examined the…”
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Binding of a highly potent protease‐activated receptor‐2 (PAR2) activating peptide, [3H]2‐furoyl‐LIGRL‐NH2, to human PAR2 by Kanke, Toru, Ishiwata, Hiroyuki, Kabeya, Mototsugu, Saka, Masako, Doi, Takeshi, Hattori, Yukio, Kawabata, Atsufumi, Plevin, Robin

“…1 To determine the binding characteristics of a highly potent agonist for protease‐activated receptor‐2 (PAR2), 2‐furoyl‐Leu‐Ile‐Gly‐Arg‐Leu‐amide…”
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Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity by Kawabata, Atsufumi, Kubo, Satoko, Ishiki, Tsuyoshi, Kawao, Naoyuki, Sekiguchi, Fumiko, Kuroda, Ryotaro, Hollenberg, Morley D, Kanke, Toru, Saito, Naohiro

“…We characterized the tracheal and bronchial relaxation caused by proteinase-activated receptor-2 (PAR-2) activation in ddY mice and/or in wild-type and…”
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2‐Furoyl‐LIGRL‐NH2, a potent agonist for proteinase‐activated receptor‐2, as a gastric mucosal cytoprotective agent in mice by Kawabata, Atsufumi, Oono, Yuko, Yonezawa, Daiki, Hiramatsu, Kaori, Inoi, Naoki, Sekiguchi, Fumiko, Honjo, Masami, Hirofuchi, Michiko, Kanke, Toru, Ishiwata, Hiroyuki

“…1 Proteinase‐activated receptor‐2 (PAR2), expressed in capsaicin‐sensitive sensory neurons, plays a protective role in gastric mucosa. The present study…”
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Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target by Kanke, Toru, Takizawa, Toshiaki, Kabeya, Mototsugu, Kawabata, Atsufumi

“…PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases. In order to…”
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The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity by Seatter, Michael J, Drummond, Robert, Kanke, Toru, Macfarlane, Scott R, Hollenberg, Morley D, Plevin, Robin

“…C-terminal truncation mutants were made to investigate the role of the C-terminus in coupling proteinase-activated receptor-2 (PAR-2) to various signalling…”
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Abrogation of Bronchial Eosinophilic Inflammation and Attenuated Eotaxin Content in Protease-Activated Receptor 2-Deficient Mice by Takizawa, Toshiaki, Tamiya, Masaki, Hara, Takuya, Matsumoto, Jiro, Saito, Naohiro, Kanke, Toru, Kawagoe, Junichi, Hattori, Yukio

“…Protease-activated receptor 2 (PAR2) belongs to the PAR family (PAR1 to PAR4), which is activated by serine proteases (trypsin, tryptase, etc.). In this study,…”
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Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro by Sekiguchi, Fumiko, Hasegawa, Naomi, Inoshita, Keiko, Yonezawa, Daiki, Inoi, Naoki, Kanke, Toru, Saito, Naohiro, Kawabata, Atsufumi

“…Proteinase-activated receptor (PAR)-1 or -2 modulates gastrointestinal transit in vivo. To clarify the underlying mechanisms, we characterized…”
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