HLA antigens in microscopic polyarteritis (MP) with renal involvement

Serological HLA-A, B, C, DR and DQ typing was performed in 23 patients with microscopic polyarteritis and renal involvement and in 405 healthy individuals, all of Greek origin. An increased frequency of HLA-A26 (26% vs. 11.3%, x2 = 4.423, p < 0.05) and HLA-A11 (26% vs. 9.6%, x2 = 6.825, P < 0....

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Bibliographic Details
Published in:	Disease markers Vol. 13; no. 2; p. 117
Main Authors:	Papasteriades, C, Hatziyannakos, D, Siakotos, M, Pappas, H, Tarassi, K, Nikolopoulou, N, Michael, S, Kaninis, C H, Vosnides, G, Sotsiou, F, Billis, A
Format:	Journal Article
Language:	English
Published:	United States 01-04-1997
Subjects:	Adolescent Adult Aged Female Glomerulonephritis - immunology Glomerulonephritis - pathology HLA Antigens - blood HLA Antigens - physiology HLA-A Antigens - blood HLA-A Antigens - physiology HLA-DR Antigens - blood HLA-DR Antigens - physiology Humans Male Middle Aged Polyarteritis Nodosa - immunology Polyarteritis Nodosa - pathology
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Summary:	Serological HLA-A, B, C, DR and DQ typing was performed in 23 patients with microscopic polyarteritis and renal involvement and in 405 healthy individuals, all of Greek origin. An increased frequency of HLA-A26 (26% vs. 11.3%, x2 = 4.423, p < 0.05) and HLA-A11 (26% vs. 9.6%, x2 = 6.825, P < 0.02), and a decreased frequency of HLA-DR3 (4.3% vs. 24.1%, x2 = 5.935, p < 0.025) were found. Five out of six patients, who did not respond to treatment possessed HLA-DR5. These observations suggest that HLA gene products may influence the clinical expression, as well as the outcome of this disease.
ISSN:	0278-0240