Search Results - "Kaniecki, Kyle"

A change of view: homologous recombination at single-molecule resolution by Kaniecki, Kyle, De Tullio, Luisina, Greene, Eric C.

“…Key Points Homologous recombination (HR) is an important pathway that enables the exchange of genetic information between DNA molecules. Single-molecule (SM)…”
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Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene by Sosnay, Patrick R, Siklosi, Karen R, Van Goor, Fredrick, Kaniecki, Kyle, Yu, Haihui, Sharma, Neeraj, Ramalho, Anabela S, Amaral, Margarida D, Dorfman, Ruslan, Zielenski, Julian, Masica, David L, Karchin, Rachel, Millen, Linda, Thomas, Philip J, Patrinos, George P, Corey, Mary, Lewis, Michelle H, Rommens, Johanna M, Castellani, Carlo, Penland, Christopher M, Cutting, Garry R

“…Garry Cutting and colleagues report a comprehensive functional and clinical analysis of CFTR variants reported in cystic fibrosis. They determine that 128 of…”
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Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase by Crickard, J. Brooks, Kaniecki, Kyle, Kwon, Youngho, Sung, Patrick, Greene, Eric C.

“…Cross-over recombination products are a hallmark of meiosis because they are necessary for accurate chromosome segregation and they also allow for increased…”
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Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2 by Kaniecki, Kyle, De Tullio, Luisina, Gibb, Bryan, Kwon, Youngho, Sung, Patrick, Greene, Eric C.

“…Srs2 is a superfamily 1 (SF1) helicase and antirecombinase that is required for genome integrity. However, the mechanisms that regulate Srs2 remain poorly…”
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Yeast Srs2 Helicase Promotes Redistribution of Single-Stranded DNA-Bound RPA and Rad52 in Homologous Recombination Regulation by De Tullio, Luisina, Kaniecki, Kyle, Kwon, Youngho, Crickard, J. Brooks, Sung, Patrick, Greene, Eric C.

“…Srs2 is a super-family 1 helicase that promotes genome stability by dismantling toxic DNA recombination intermediates. However, the mechanisms by which Srs2…”
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Monitoring Replication Protein A (RPA) dynamics in homologous recombination through site-specific incorporation of non-canonical amino acids by Pokhrel, Nilisha, Origanti, Sofia, Davenport, Eric Parker, Gandhi, Disha, Kaniecki, Kyle, Mehl, Ryan A, Greene, Eric C, Dockendorff, Chris, Antony, Edwin

“…An essential coordinator of all DNA metabolic processes is Replication Protein A (RPA). RPA orchestrates these processes by binding to single-stranded DNA…”
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Single-Stranded DNA Curtains for Studying the Srs2 Helicase Using Total Internal Reflection Fluorescence Microscopy by De Tullio, Luisina, Kaniecki, Kyle, Greene, Eric C

“…Helicases are crucial participants in many types of DNA repair reactions, including homologous recombination. The properties of these enzymes can be assayed by…”
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Regulation of Hed1 and Rad54 binding during maturation of the meiosis‐specific presynaptic complex by Crickard, J Brooks, Kaniecki, Kyle, Kwon, YoungHo, Sung, Patrick, Lisby, Michael, Greene, Eric C

“…Most eukaryotes have two Rad51/RecA family recombinases, Rad51, which promotes recombination during mitotic double‐strand break (DSB) repair, and the…”
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Spontaneous self-segregation of Rad51 and Dmc1 DNA recombinases within mixed recombinase filaments by Crickard, J. Brooks, Kaniecki, Kyle, Kwon, YoungHo, Sung, Patrick, Greene, Eric C.

“…During meiosis, the two DNA recombinases Rad51 and Dmc1 form specialized presynaptic filaments that are adapted for performing recombination between homologous…”
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Rapid tolerance to behavioral effects of ethanol in rats: Prevention by R-(−)-ketamine by Shafique, Hana, Witkin, Jeffrey M., Smith, Jodi L., Kaniecki, Kyle, Sporn, Jonathan, Holuj, Malgorzata, Krawczyk, Martyna, Kuziak, Agata, Popik, Piotr

“…R-(−)-ketamine has emerged as a potentially improved medication over that of the (S)-isomer (marketed as Spravato for depression). Recent data have suggested…”
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Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates by Xue, Chaoyou, Molnarova, Lucia, Steinfeld, Justin B, Zhao, Weixing, Ma, Chujian, Spirek, Mario, Kaniecki, Kyle, Kwon, Youngho, Beláň, Ondrej, Krejci, Katerina, Boulton, Simon J, Sung, Patrick, Greene, Eric C, Krejci, Lumir

“…Abstract RECQ5 is one of five RecQ helicases found in humans and is thought to participate in homologous DNA recombination by acting as a negative regulator of…”
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The Saccharomyces cerevisiae Srs2 Helicase Regulates Homologous Recombination through the Disassembly of Recombination Intermediates by Kaniecki, Kyle S

“…Life on Earth relies on a set of instructions encoded within an organism’s genome that is passed along from one generation to the next. Inherent to this…”
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