Search Results - "Kanick, Stephen C."

Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection by Roberts, David W, Olson, Jonathan D, Evans, Linton T, Kolste, Kolbein K, Kanick, Stephen C, Fan, Xiaoyao, Bravo, Jaime J, Wilson, Brian C, Leblond, Frederic, Marois, Mikael, Paulsen, Keith D

“…OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field…”
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Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance by Kolste, Kolbein K, Kanick, Stephen C, Valdés, Pablo A, Jermyn, Michael, Wilson, Brian C, Roberts, David W, Paulsen, Keith D, Leblond, Frederic

“…A diffuse imaging method is presented that enables wide-field estimation of the depth of fluorescent molecular markers in turbid media by quantifying the…”
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Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers by Kanick, Stephen C., Schneider, Peter A., Klitzman, Bruce, Wisniewski, Natalie A., Rebrin, Kerstin

“…Measurements of regional tissue oxygen serve as a proxy to monitor local perfusion and have the potential to guide therapeutic decisions in multiple clinical…”
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Revisiting photodynamic therapy dosimetry: reductionist & surrogate approaches to facilitate clinical success by Pogue, Brian W, Elliott, Jonathan T, Kanick, Stephen C, Davis, Scott C, Samkoe, Kimberley S, Maytin, Edward V, Pereira, Stephen P, Hasan, Tayyaba

“…Photodynamic therapy (PDT) can be a highly complex treatment, with many parameters influencing treatment efficacy. The extent to which dosimetry is used to…”
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Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging by Tichauer, Kenneth M, Samkoe, Kimberley S, Gunn, Jason R, Kanick, Stephen C, Hoopes, P Jack, Barth, Richard J, Kaufman, Peter A, Hasan, Tayyaba, Pogue, Brian W

“…Tichauer et al . describe a dual-tracer approach to quantify cancer cell receptor concentrations, in this case epidermal growth factor receptor, in lymph…”
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Special Section Guest Editorial: Wearable, Implantable, Mobile, and Remote Biomedical Optics and Photonics by Ramella-Roman, Jessica, Gandjbakhche, Amir H, Kanick, Stephen C, Shadgan, Babak, Tromberg, Bruce J

“…Guest editors Jessica Ramella-Roman, Amir H. Gandjbakhche, Stephen C. Kanick, Babak Shadgan, and Bruce J. Tromberg introduce and summarize the articles…”
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Hyperspectral dark-field microscopy of human breast lumpectomy samples for tumor margin detection in breast-conserving surgery by Hwang, Jeeseong, Cheney, Philip, Kanick, Stephen C., Le, Hanh N. D., McClatchy, David M., Zhang, Helen, Liu, Nian, John Lu, Zhan-Qian, Cho, Tae Joon, Briggman, Kimberly, Allen, David W., Wells, Wendy A., Pogue, Brian W.

“…Hyperspectral dark-field microscopy (HSDFM) and data cube analysis algorithms demonstrate successful detection and classification of various tissue types,…”
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Sub-diffuse optical biomarkers characterize localized microstructure and function of cortex and malignant tumor by Bravo, Jaime J, Paulsen, Keith D, Roberts, David W, Kanick, Stephen C

“…This study uses a sub-diffusive light transport model to analyze fiber-optic measurements of reflectance spectra to recover endogenous tissue biomarkers and to…”
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A GAMOS plug-in for GEANT4 based Monte Carlo simulation of radiation-induced light transport in biological media by Glaser, Adam K, Kanick, Stephen C, Zhang, Rongxiao, Arce, Pedro, Pogue, Brian W

“…We describe a tissue optics plug-in that interfaces with the GEANT4/GAMOS Monte Carlo (MC) architecture, providing a means of simulating radiation-induced…”
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Light scattering measured with spatial frequency domain imaging can predict stromal versus epithelial proportions in surgically resected breast tissue by McClatchy, David M, Rizzo, Elizabeth J, Wells, Wendy A, Black, Candice C, Paulsen, Keith D, Kanick, Stephen C, Pogue, Brian W

“…This study aims to determine if light scatter parameters measured with spatial frequency domain imaging (SFDI) can accurately predict stromal, epithelial, and…”
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Wide-field quantitative imaging of tissue microstructure using sub-diffuse spatial frequency domain imaging by McClatchy, 3rd, David M, Rizzo, Elizabeth J, Wells, Wendy A, Cheney, Philip P, Hwang, Jeeseong C, Paulsen, Keith D, Pogue, Brian W, Kanick, Stephen C

“…Localized measurements of scattering in biological tissue provide sensitivity to microstructural morphology but have limited utility to wide-field…”
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Pulsed-light imaging for fluorescence guided surgery under normal room lighting by Sexton, Kristian, Davis, Scott C, McClatchy, 3rd, David, Valdes, Pablo A, Kanick, Stephen C, Paulsen, Keith D, Roberts, David W, Pogue, Brian W

“…Fluorescence guided surgery (FGS) is an emerging technology that has demonstrated improved surgical outcomes. However, dim lighting conditions required by…”
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Separation of Solid Stress From Interstitial Fluid Pressure in Pancreas Cancer Correlates With Collagen Area Fraction by Nieskoski, Michael D, Marra, Kayla, Gunn, Jason R, Kanick, Stephen C, Doyley, Marvin M, Hasan, Tayyaba, Pereira, Stephen P, Stuart Trembly, B, Pogue, Brian W

“…Elevated total tissue pressure (TTP) in pancreatic adenocarcinoma is often associated with stress applied by cellular proliferation and hydrated hyaluronic…”
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Method to quantitatively estimate wavelength-dependent scattering properties from multidiameter single fiber reflectance spectra measured in a turbid medium by Kanick, Stephen C, Gamm, Ute A, Sterenborg, Henricus J C M, Robinson, Dominic J, Amelink, Arjen

“…This study utilizes experimentally validated Monte Carlo simulations to identify a mathematical formulation of the reflectance intensity collected by a single…”
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Method to quantitate absorption coefficients from single fiber reflectance spectra without knowledge of the scattering properties by Kanick, Stephen C, Robinson, Dominic J, Sterenborg, Henricus J C M, Amelink, Arjen

“…This study presents a methodology to accurately extract the absorption coefficient from single fiber reflectance spectra measured in turbid media without a…”
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Mathematical model to interpret localized reflectance spectra measured in the presence of a strong fluorescence marker by Bravo, Jaime J, Davis, Scott C, Roberts, David W, Paulsen, Keith D, Kanick, Stephen C

“…Quantification of multiple fluorescence markers during neurosurgery has the potential to provide complementary contrast mechanisms between normal and malignant…”
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Extraction of intrinsic fluorescence from single fiber fluorescence measurements on a turbid medium by Kanick, Stephen C, Robinson, Dominic J, Sterenborg, Henricus J C M, Amelink, Arjen

“…This study utilizes Monte Carlo simulations of single fiber fluorescence to develop an empirical model that corrects for the influence of scattering and…”
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Pixel-based absorption correction for dual-tracer fluorescence imaging of receptor binding potential by Kanick, Stephen C, Tichauer, Kenneth M, Gunn, Jason, Samkoe, Kimberley S, Pogue, Brian W

“…Ratiometric approaches to quantifying molecular concentrations have been used for decades in microscopy, but have rarely been exploited in vivo until recently…”
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Pharmacokinetic modeling of motexafin gadolinium disposition in mouse tissues using optical pharmacokinetic system measurements by Kanick, Stephen C., PhD, Eiseman, Julie L., PhD, Parker, Robert S., PhD

“…Summary Clinical use of radio- or photo-sensitizing agents in anti-cancer treatments may be limited by patient specific variability in the pharmacokinetics…”
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White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX by Flynn, Brendan P, DSouza, Alisha V, Kanick, Stephen C, Davis, Scott C, Pogue, Brian W

“…Subsurface fluorescence imaging is desirable for medical applications, including protoporphyrin-IX (PpIX)-based skin tumor diagnosis, surgical guidance, and…”
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