Search Results - "Kang, Ya'an"

MiR-21-mediated Metabolic Alteration of Cancer-associated Fibroblasts and Its Effect on Pancreatic Cancer Cell Behavior by Chen, Shuo, Chen, Xi, Shan, Tao, Ma, Jiancang, Lin, Wanrun, Li, Wei, Kang, Ya'an

“…In this study, we investigated whether the metabolic alteration of (CAFs) occurs via miR-21 remodeling and the effect of this alteration on pancreatic cancer…”
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Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism by Shan, Tao, Chen, Shuo, Chen, Xi, Lin, Wan Run, Li, Wei, Ma, Jiancang, Wu, Tao, Cui, Xijuan, Ji, Hong, Li, Yiming, Kang, Ya'An

“…We investigated the mechanism of cancer-associated fibroblasts (CAFs) in promoting the invasion and metastasis of pancreatic cancer cells in a non-vascular…”
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Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation by Wang, Yan, Hsu, Jung-Mao, Kang, Ya'an, Wei, Yongkun, Lee, Pei-Chih, Chang, Shing-Jyh, Hsu, Yi-Hsin, Hsu, Jennifer L, Wang, Hung-Ling, Chang, Wei-Chao, Li, Chia-Wei, Liao, Hsin-Wei, Chang, Shih-Shin, Xia, Weiya, Ko, How-Wen, Chou, Chao-Kai, Fleming, Jason B, Wang, Huamin, Hwang, Rosa F, Chen, Yue, Qin, Jun, Hung, Mien-Chie

“…The oncogenic transcription factor Gli1 is a critical effector in the Hedgehog (Hh) pathway, which is necessary for the development and progression of…”
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Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells by ZHE CHANG, ZHONGKUI LI, ABBRUZZESE, James L, CHIAO, Paul J, XIAOYANG WANG, YA'AN KANG, YUHUI YUAN, JIANGONG NIU, HUAMIN WANG, CHATTERJEE, Deyali, FLEMING, Jason B, MIN LI

“…The most common genetic lesions in pancreatic ductal adenocarcinoma (PDAC) have been identified. However, significant gaps still exist in our understanding of…”
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Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma by Mottini, Carla, Tomihara, Hideo, Carrella, Diego, Lamolinara, Alessia, Iezzi, Manuela, Huang, Justin K, Amoreo, Carla A, Buglioni, Simonetta, Manni, Isabella, Robinson, Frederick S, Minelli, Rosalba, Kang, Ya'an, Fleming, Jason B, Kim, Michael P, Bristow, Christopher A, Trisciuoglio, Daniela, Iuliano, Antonella, Del Bufalo, Donatella, Di Bernardo, Diego, Melisi, Davide, Draetta, Giulio F, Ciliberto, Gennaro, Carugo, Alessandro, Cardone, Luca

“…Mutated KRAS protein is a pivotal tumor driver in pancreatic cancer. However, despite comprehensive efforts, effective therapeutics that can target oncogenic…”
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SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium by Kang, Ya'an, Ling, Jianhua, Suzuki, Rei, Roife, David, Chopin-Laly, Xavier, Truty, Mark J, Chatterjee, Deyali, Wang, Huamin, Thomas, Ryan M, Katz, Matthew H, Chiao, Paul J, Fleming, Jason B

“…Expression of the cellular adhesion protein N-cadherin is a critical event during epithelial-mesenchymal transition (EMT). The SMAD4 protein has been…”
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CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop by Chen, Yihui, Capello, Michela, Rios Perez, Mayrim V., Vykoukal, Jody V., Roife, David, Kang, Ya'an, Prakash, Laura R., Katayama, Hiroyuki, Irajizad, Ehsan, Fleury, Alia, Ferri-Borgogno, Sammy, Baluya, Dodge L., Dennison, Jennifer B., Do, Kim-Anh, Fiehn, Oliver, Maitra, Anirban, Wang, Huamin, Chiao, Paul J., Katz, Matthew H.G., Fleming, Jason B., Hanash, Samir M., Fahrmann, Johannes F.

“…Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal…”
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Clinical significance of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in pancreatic ductal adenocarcinoma by Waragai, Yuichi, Suzuki, Rei, Takagi, Tadayuki, Sugimoto, Mitsuru, Asama, Hiroyuki, Watanabe, Ko, Kikuchi, Hitomi, Hikichi, Takuto, Masamune, Atsushi, Kang, Ya'an, Fleming, Jason B, Ohira, Hiromasa

“…Abstract Background Wisteria floribunda agglutinin-positive mac-2 binding protein (WFA+ -M2BP) is an excellent biomarker for predicting hepatic fibrosis. We…”
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Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models by Rios Perez, Mayrim V., Roife, David, Dai, Bingbing, Pratt, Michael, Dobrowolski, Ryszard, Kang, Ya'an, Li, Xinqun, Augustine, Jithesh J., Zielinski, Rafal, Priebe, Waldemar, Fleming, Jason B.

“…Auranofin, a Food and Drug Administration–approved anti-rheumatic agent with anticancer properties for lung and ovarian cancer, has never been studied for…”
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Defective feedback regulation of NF-κB underlies Sjögren's syndrome in mice with mutated κB enhancers of the IκBα promoter by Peng, Bailu, Ling, Jianhua, Lee, Andrew Joon, Wang, Zilai, Chang, Zhe, Jin, Wei, Kang, Ya'an, Zhang, Richard, Shim, David, Wang, Huamin, Fleming, Jason B, Zheng, Hui, Sun, Shao-Cong, Chiao, Paul J

“…Feedback regulation of transcription factor NF-κB by its inhibitor IκBα plays an essential role in control of NF-κB activity. To understand the biological…”
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Clinical candidate and genistein analogue AXP107‐11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein‐coupled estrogen receptor signaling by Mesmar, Fahmi, Dai, Bingbing, Ibrahim, Ahmed, Hases, Linnea, Jafferali, Mohammed Hakim, Jose Augustine, Jithesh, DiLorenzo, Sebastian, Kang, Ya'an, Zhao, Yang, Wang, Jing, Kim, Michael, Lin, Chin‐Yo, Berkenstam, Anders, Fleming, Jason, Williams, Cecilia

“…Despite advances in cancer therapeutics, pancreatic cancer remains difficult to treat and often develops resistance to chemotherapies. We have evaluated a…”
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Silencing thioredoxin induces liver cancer cell senescence under hypoxia by Zhang, Ti, Liu, Heping, Zhu, Cihui, Briggs, Katrina, Kang, Ya'an, Fleming, Jason A., Curley, Steven A.

“…Aim:  Although thioredoxin 1 (TXN) has pleiotropic cellular functions as a redox‐sensitive protein, very little is known about its role in tumor survival and…”
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SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy by Wang, Feng, Xia, Xiaojun, Yang, Chunying, Shen, Jianliang, Mai, Junhua, Kim, Han-Cheon, Kirui, Dickson, Kang, Ya'an, Fleming, Jason B, Koay, Eugene J, Mitra, Sankar, Ferrari, Mauro, Shen, Haifa

“…Understanding the mechanism of radioresistance could help develop strategies to improve therapeutic response of patients with PDAC. The gene is frequently…”
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Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma by Li, Xinqun, Lee, Yeonju, Kang, Ya'an, Dai, Bingbing, Perez, Mayrim Rios, Pratt, Michael, Koay, Eugene J, Kim, Michael, Brekken, Rolf A, Fleming, Jason B

“…Lumican is secreted by pancreatic stellate cells and inhibits cancer progression. Extracellular lumican inhibits cancer cell replication and restrains growth…”
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IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway by Sun, Longhao, Zhang, Xuebin, Song, Qianqian, Liu, Liang, Forbes, Elizabeth, Tian, Weijun, Zhang, Zhixiang, Kang, Ya'an, Wang, Huamin, Fleming, Jason B., Pasche, Boris C., Zhang, Wei

“…Tumor-associated macrophages (TAMs) represent the M2-like phenotype with potent immunosuppressive activity, and play a pro-tumor role in pancreatic ductal…”
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Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI) by Schechter, Norman M, Choi, Eun-Jung, Wang, Zhe-Mei, Hanakawa, Yasushi, Stanley, John R, Kang, Ya'an, Clayman, Gary L, Jayakumar, Arumugam

“…LEKTI is a 120-kDa protein that plays an important role in skin development, as mutations affecting LEKTI synthesis underlie Netherton syndrome, an inherited…”
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Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis by Kim, Michael P, Li, Xinqun, Deng, Jenying, Zhang, Yun, Dai, Bingbing, Allton, Kendra L, Hughes, Tara G, Siangco, Christian, Augustine, Jithesh J, Kang, Ya'an, McDaniel, Joy M, Xiong, Shunbin, Koay, Eugene J, McAllister, Florencia, Bristow, Christopher A, Heffernan, Timothy P, Maitra, Anirban, Liu, Bin, Barton, Michelle C, Wasylishen, Amanda R, Fleming, Jason B, Lozano, Guillermina

“…Pancreatic ductal adenocarcinoma (PDAC) is almost uniformly fatal and characterized by early metastasis. Oncogenic mutations prevail in 95% of PDAC tumors and…”
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway by Son, Jaekyoung, Lyssiotis, Costas A., Ying, Haoqiang, Wang, Xiaoxu, Hua, Sujun, Ligorio, Matteo, Perera, Rushika M., Ferrone, Cristina R., Mullarky, Edouard, Shyh-Chang, Ng, Kang, Ya’an, Fleming, Jason B., Bardeesy, Nabeel, Asara, John M., Haigis, Marcia C., DePinho, Ronald A., Cantley, Lewis C., Kimmelman, Alec C.

“…Pancreatic cancers use a novel glutamine metabolism pathway, regulated by oncogenic KRAS, to maintain redox balance; these findings add to the understanding of…”
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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function by Viale, Andrea, Pettazzoni, Piergiorgio, Lyssiotis, Costas A., Ying, Haoqiang, Sánchez, Nora, Marchesini, Matteo, Carugo, Alessandro, Green, Tessa, Seth, Sahil, Giuliani, Virginia, Kost-Alimova, Maria, Muller, Florian, Colla, Simona, Nezi, Luigi, Genovese, Giannicola, Deem, Angela K., Kapoor, Avnish, Yao, Wantong, Brunetto, Emanuela, Kang, Ya’an, Yuan, Min, Asara, John M., Wang, Y. Alan, Heffernan, Timothy P., Kimmelman, Alec C., Wang, Huamin, Fleming, Jason B., Cantley, Lewis C., DePinho, Ronald A., Draetta, Giulio F.

“…KRAS mutations are a driver event of pancreatic ductal adenocarcinoma; here, a subpopulation of dormant tumour cells, relying on oxidative phosphorylation for…”
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Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition by Yan, Liang, Tu, Bo, Yao, Jun, Gong, Jing, Carugo, Alessandro, Bristow, Christopher A, Wang, Qiuyun, Zhu, Cihui, Dai, Bingbing, Kang, Ya'an, Han, Leng, Feng, Ningping, Jin, Yanqing, Fleming, Jason, Heffernan, Timothy P, Yao, Wantong, Ying, Haoqiang

“…Pancreatic ductal adenocarcinoma (PDAC) is almost universally lethal. A critical unmet need exists to explore essential susceptibilities in PDAC and to…”
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