Search Results - "Kang, Seokjo"

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease by Baik, Sung Hoon, Kang, Seokjo, Lee, Woochan, Choi, Hayoung, Chung, Sunwoo, Kim, Jong-Il, Mook-Jung, Inhee

“…Reactive microglia are a major pathological feature of Alzheimer's disease (AD). However, the exact role of microglia in AD pathogenesis is still unclear…”
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Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease by Son, Sung Min, Cha, Moon-Yong, Choi, Heesun, Kang, Seokjo, Choi, Hyunjung, Lee, Myung-Shik, Park, Sun Ah, Mook-Jung, Inhee

“…The secretion of proteins that lack a signal sequence to the extracellular milieu is regulated by their transition through the unconventional secretory…”
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Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging by Kang, Seokjo, Ko, Emily Y, Andrews, Amelia E, Shin, Juliana E, Nance, Karina J, Barman, Pijus K, Heeger, Peter S, Freeman, Willard M, Benayoun, Bérénice A, Goodridge, Helen S

“…Microglia, the brain's resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but…”
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Close Correlation of Monoamine Oxidase Activity with Progress of Alzheimer’s Disease in Mice, Observed by in Vivo Two-Photon Imaging by Kim, Dokyoung, Baik, Sung Hoon, Kang, Seokjo, Cho, Seo Won, Bae, Juryang, Cha, Moon-Yong, Sailor, Michael J, Mook-Jung, Inhee, Ahn, Kyo Han

“…Monoamine oxidases (MAOs) play an important role in Alzheimer’s disease (AD) pathology. We report in vivo comonitoring of MAO activity and amyloid-β (Aβ)…”
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Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease by Kang, Seokjo, Moser, V. Alexandra, Svendsen, Clive N., Goodridge, Helen S.

“…Parabiosis, blood exchange and plasma transfer experiments have highlighted the rejuvenating properties of young blood. Our Communications Biology study…”
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PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer's Disease by Kang, Seokjo, Jeong, Hyobin, Baek, Je-Hyun, Lee, Seung-Jin, Han, Sun-Ho, Cho, Hyun Jin, Kim, Hee, Hong, Hyun Seok, Kim, Young Ho, Yi, Eugene C, Seo, Sang Won, Na, Duk L, Hwang, Daehee, Mook-Jung, Inhee

“…Development of a simple, non-invasive early diagnosis platform of Alzheimer's disease (AD) using blood is urgently required. Recently, PiB-PET imaging has been…”
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SGIP1α, but Not SGIP1, is an Ortholog of FCHo Proteins and Functions as an Endocytic Regulator by Lee, Sang-Eun, Cho, Eunji, Jeong, Soomin, Song, Yejij, Kang, Seokjo, Chang, Sunghoe

“…Src homology 3-domain growth factor receptor-bound 2-like interacting protein 1 (SGIP1), originally known as a regulator of energy homeostasis, was later found…”
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Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model by Baik, Sung Hoon, Kang, Seokjo, Son, Sung Min, Mook-Jung, Inhee

“…Pathological hallmarks of Alzheimer's disease (AD) include extracellularly accumulated amyloid β (Aβ) plaques and intracellular neurofibrillary tangles in the…”
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Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway by Son, Sung Min, Kang, Seokjo, Choi, Heesun, Mook-Jung, Inhee

“…Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer's disease (AD) pathogenesis. Previous…”
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Impact of aging on monocyte subset production by bone marrow progenitors by Goodridge, Helen Sara, Barman, Pijus K, Shin, Juliana, Wu, Di, Kang, Seokjo

“…Monocytes can patrol the circulation or be recruited into tissues to become macrophages or monocyte-derived dendritic cells (moDCs). We previously showed that…”
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Production of MHCII‐expressing classical monocytes increases during aging in mice and humans by Barman, Pijus K., Shin, Juliana E., Lewis, Sloan A., Kang, Seokjo, Wu, Di, Wang, Yizhou, Yang, Xiaoming, Nagarkatti, Prakash S., Nagarkatti, Mitzi, Messaoudi, Ilhem, Benayoun, Bérénice A., Goodridge, Helen S.

“…Aging is associated with increased monocyte production and altered monocyte function. Classical monocytes are heterogenous and a shift in their subset…”
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Thrombospondin-1 protects against Aβ-induced mitochondrial fragmentation and dysfunction in hippocampal cells by Kang, Seokjo, Byun, Jayoung, Son, Sung Min, Mook-Jung, Inhee

“…Alzheimer’s disease (AD) is often characterized by the impairment of mitochondrial function caused by excessive mitochondrial fragmentation. Thrombospondin-1…”
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Microglia contributes to plaque growth by cell death due to uptake of amyloid [beta] in the brain of Alzheimer's disease mouse model by Baik, Sung Hoon, Kang, Seokjo, Son, Sung Min, Mook-Jung, Inhee

“…Pathological hallmarks of Alzheimer's disease (AD) include extracellularly accumulated amyloid [beta] (A[beta]) plaques and intracellular neurofibrillary…”
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Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model: Aβ Plaque Formation and Microglial Activation by Baik, Sung Hoon, Kang, Seokjo, Son, Sung Min, Mook-Jung, Inhee

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Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition by Park, Jong-Chan, Han, Sun-Ho, Cho, Hyun Jin, Byun, Min Soo, Yi, Dahyun, Choe, Young Min, Kang, Seokjo, Jung, Eun Sun, Won, Su Jin, Kim, Eun Hye, Kim, Yu Kyeong, Lee, Dong Young, Mook-Jung, Inhee

“…Plasma β-amyloid (Aβ) is a potential candidate for an Alzheimer's disease (AD) biomarker because blood is an easily accessible bio-fluid, which can be…”
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Chemically treated plasma ABeta is a potential blood-based biomarker for screening cerebral amyloid deposition by Jong-Chan, Park, Sun-Ho, Han, Hyun Jin Cho, Byun, Min Soo, Yi, Dahyun, Choe, Young Min, Kang, Seokjo, Eun Sun Jung, Su, Jin Won, Kim, Eun Hye, Kim, Yu Kyeong, Dong Young Lee, Mook-Jung, Inhee

“…Background Plasma β-amyloid (Aβ) is a potential candidate for an Alzheimer’s disease (AD) biomarker because blood is an easily accessible bio-fluid, which can…”
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