Search Results - "Kang, Po Wei"

Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation by Hou, Panpan, Kang, Po Wei, Kongmeneck, Audrey Deyawe, Yang, Nien-Du, Liu, Yongfeng, Shi, Jingyi, Xu, Xianjin, White, Kelli McFarland, Zaydman, Mark A., Kasimova, Marina A., Seebohm, Guiscard, Zhong, Ling, Zou, Xiaoqin, Tarek, Mounir, Cui, Jianmin

“…In voltage-gated potassium (K V ) channels, the voltage-sensing domain (VSD) undergoes sequential activation from the resting state to the intermediate state…”
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Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state by Taylor, Keenan C, Kang, Po Wei, Hou, Panpan, Yang, Nien-Du, Kuenze, Georg, Smith, Jarrod A, Shi, Jingyi, Huang, Hui, White, Kelli McFarland, Peng, Dungeng, George, Alfred L, Meiler, Jens, McFeeters, Robert L, Cui, Jianmin, Sanders, Charles R

“…Voltage-gated ion channels feature voltage sensor domains (VSDs) that exist in three distinct conformations during activation: resting, intermediate, and…”
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Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels by Ben-Johny, Manu, Dick, Ivy E, Sang, Lingjie, Limpitikul, Worawan B, Kang, Po Wei, Niu, Jacqueline, Banerjee, Rahul, Yang, Wanjun, Babich, Jennifer S, Issa, John B, Lee, Shin Rong, Namkung, Ho, Li, Jiangyu, Zhang, Manning, Yang, Philemon S, Bazzazi, Hojjat, Adams, Paul J, Joshi-Mukherjee, Rosy, Yue, Daniel N, Yue, David T

“…Voltage-gated Na and Ca(2+) channels represent two major ion channel families that enable myriad biological functions including the generation of action…”
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Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation by Angsutararux, Paweorn, Kang, Po Wei, Zhu, Wandi, Silva, Jonathan R.

“…Voltage-gated Na+ (NaV) channels underlie the initiation and propagation of action potentials (APs). Rapid inactivation after NaV channel opening, known as…”
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A Gain‐of‐Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy by Zhang, Guohui, Gibson, Rebecca A., McDonald, Marie, Liang, Pengfei, Kang, Po Wei, Shi, Jingyi, Yang, Huanghe, Cui, Jianmin, Mikati, Mohamad A.

“…Background The mutations of KCNMA1 BK‐type K+ channel have been identified in patients with various movement disorders. The underlying pathophysiology and…”
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Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening by Kang, Po Wei, Westerlund, Annie M, Shi, Jingyi, White, Kelli McFarland, Dou, Alex K, Cui, Amy H, Silva, Jonathan R, Delemotte, Lucie, Cui, Jianmin

“…Calmodulin (CaM) and phosphatidylinositol 4,5-bisphosphate (PIP ) are potent regulators of the voltage-gated potassium channel KCNQ1 (K 7.1), which conducts…”
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Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia by Schiffhauer, Eric S, Vij, Neeraj, Kovbasnjuk, Olga, Kang, Po Wei, Walker, Doug, Lee, Seakwoo, Zeitlin, Pamela L

“…Multiple sodium and chloride channels on the apical surface of nasal epithelial cells contribute to periciliary fluid homeostasis, a function that is disrupted…”
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Aberrant QRS morphologies during atrial tachycardia: What is the mechanism? by Kang, Po wei, Wong, Kristen E., Smith, Timothy W.

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Elementary mechanisms of calmodulin regulation of NaV1.5 producing divergent arrhythmogenic phenotypes by Kang, Po Wei, Chakouri, Nourdine, Diaz, Johanna, Tomaselli, Gordon F., Yue, David T., Ben-Johny, Manu

“…In cardiomyocytes, NaV1.5 channels mediate initiation and fast propagation of action potentials. The Ca2+-binding protein calmodulin (CaM) serves as a de facto…”
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B-PO03-016 DISEASE-ASSOCIATED CALMODULIN VARIANTS INTERACTION WITH THE KCNQ1 POTASSIUM CHANNEL by Kang, Po Wei, Angsutararux, Paweorn, Shi, Jingyi, Marras, Martina, Abella, Carlota, Cui, Jianmin, Silva, Jonathan

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Aberrant Calmodulin Regulation of NaV1.5 Channels Linked to Inherited Cardiac Arrhythmia by Chakouri, Nourdine, wei Kang, Po, Diaz, Johanna, Tomaselli, Gordon F., Johny, Manu B.

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Disease associated CaM variants interact with KCNQ1 to confer aberrant membrane trafficking and function by Wei Kang, Po, Woodbury, Lucy S., Angsutararux, Paweorn, Sambare, Namit, Shi, Jingyi, Marras, Martina, Abella, Carlota, Bedi, Anish, Zinn, DeShawn, Cui, Jianmin, Silva, Jonathan R.

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Mutations affecting electro-mechanical coupling in KCNQ channels alter kinetics and voltage dependence of activation by Yang, Nien-Du, Zhao, Lu, Kanyo, Richard, Li, Jingru, Wei Kang, Po, Dou, Alex K., McFarland White, Kelli, Shi, Jingyi, Nerbonne, Jeanne M., Kurata, Harley T., Cui, Jianmin

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Elementary mechanisms of calmodulin regulation of Na V 1.5 producing divergent arrhythmogenic phenotypes by Kang, Po Wei, Chakouri, Nourdine, Diaz, Johanna, Tomaselli, Gordon F, Yue, David T, Ben-Johny, Manu

“…In cardiomyocytes, Na 1.5 channels mediate initiation and fast propagation of action potentials. The Ca -binding protein calmodulin (CaM) serves as a de facto…”
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Gating Mechanisms of Cardiac and Neuronal KCNQ Potassium Channels by Yang, Nien-Du, Dou, Alex, Kang, Po Wei, Hou, Panpan, McFarland White, Kelli, Shi, Jingyi, Cui, Jianmin

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Mechanisms of KCNQ1-Calmodulin Channel Complex Activation to Dual Open States by Kang, Po wei

“…Voltage-gated potassium channels (KV) facilitate cellular excitability essential for cardiac contraction and neuronal spiking. In response to changes in the…”
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Calmodulin Functionally Couples the KCNQ1 Channel Voltage-Sensing and Pore Domains by Kang, Po Wei, Westerlund, Annie M., Shi, Jingyi, McFarland White, Kelli, Dou, Alex K., Silva, Jonathan R., Delemotte, Lucie, Cui, Jianmin

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Structure and Physiological Function of the KCNQ1 Channel Voltage Sensor Intermediate State by Sanders, Charles R., Taylor, Keenan C., Wei Kang, Po, Hou, Panpan, Yang, Nien-Du, Kuenze, Georg, George, Alfred L., Meiler, Jens, McFeeters, Robert L., Cui, Jianmin

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Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects by Lin, Yangyang, Grinter, Sam Z., Lu, Zhongju, Xu, Xianjin, Wang, Hong Zhan, Liang, Hongwu, Hou, Panpan, Gao, Junyuan, Clausen, Chris, Shi, Jingyi, Zhao, Wenshan, Ma, Zhiwei, Liu, Yongfeng, White, Kelli McFarland, Zhao, Lu, Kang, Po Wei, Zhang, Guohui, Cohen, Ira S., Zou, Xiaoqin, Cui, Jianmin

“…Cardiac arrhythmias are the most common cause of sudden cardiac death worldwide. Lengthening the ventricular action potential duration (APD), either…”
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Robust, Automated Analysis of Electrophysiology in Induced Pluripotent Stem Cell-Derived Micro-Heart Muscle for Drug Toxicity by Oguntuyo, Kasoorelope, Schuftan, David, Guo, Jingxuan, Simmons, Daniel, Bhagavan, Druv, Moreno, Jonathan D, Kang, Po Wei, Miller, Evan, Silva, Jonathan R, Huebsch, Nathaniel

“…Drugs are often removed from clinical trials or market progression owing to their unforeseen effects on cardiac action potential and calcium handling. Induced…”
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