Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus

Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus

•Sleep deprivation enhances the expression of hippocampal 5-HT1A receptors.•5-HT induced depression of hippocampal CA1 pEPSPs is larger in SD rats.•A 24 or 48h sleep recovery diminished the effect of 5-HT. A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in...

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Bibliographic Details
Published in:Neuroscience letters Vol. 655; pp. 151 - 155
Main Authors: Azizi, H., Hwang, J., Suen, V., Kang, N.Z., Somvanshi, R., Tadavarty, R., Kumar, U., Sastry, B.R.
Format: Journal Article
Language:English
Published: Elsevier B.V 10-08-2017
Subjects:
5-HT
CA1
EPSP
Hippocampus
Serotonin
Sleep deprivation
EPSP
CA1
Serotonin
5-HT
Hippocampus
Sleep deprivation
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Summary:•Sleep deprivation enhances the expression of hippocampal 5-HT1A receptors.•5-HT induced depression of hippocampal CA1 pEPSPs is larger in SD rats.•A 24 or 48h sleep recovery diminished the effect of 5-HT. A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.
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ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2017.06.053