Search Results - "Kang, Min Jong"

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases by Dela Cruz, Charles S, Kang, Min-Jong

“…Inflammation represents a comprehensive host response to external stimuli for the purpose of eliminating the offending agent, minimizing injury to host tissues…”
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Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury by Lee, Chun Geun, Da Silva, Carla A, Dela Cruz, Charles S, Ahangari, Farida, Ma, Bing, Kang, Min-Jong, He, Chuan-Hua, Takyar, Seyedtaghi, Elias, Jack A

“…The 18 glycosyl hydrolase family of chitinases is an ancient gene family that is widely expressed from prokaryotes to eukaryotes. In mammals, despite the…”
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Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains by Hao, Zichen, Li, Jun, Li, Bo, Alder, Kareme D, Cahill, Sean V, Munger, Alana M, Lee, Inkyu, Kwon, Hyuk‐Kwon, Back, JungHo, Xu, Shuogui, Kang, Min‐Jong, Lee, Francis Y

“…ABSTRACT Smokers are at a higher risk of delayed union or nonunion after fracture repair. Few specific interventions are available for prevention because the…”
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Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis by Jang, Yoon Ok, Lee, Se Hee, Choi, Jong Jin, Kim, Do-Hyun, Choi, Je-Min, Kang, Min-Jong, Oh, Yeon-Mok, Park, Young-Jun, Shin, Yong, Lee, Sei Won

“…Recent work has suggested a microbial dysbiosis association between the lung and gut in respiratory diseases. Here, we demonstrated that gut microbiome…”
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Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis by Kim, Do-Hyun, Park, Hong-Jai, Lim, Sangho, Koo, Ja-Hyun, Lee, Hong-Gyun, Choi, Jin Ouk, Oh, Ji Hoon, Ha, Sang-Jun, Kang, Min-Jong, Lee, Chang-Min, Lee, Chun Geun, Elias, Jack A., Choi, Je-Min

“…Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T…”
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Nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung‐like changes by Shin, Hyeon Jun, Kim, Sang‐Hun, Park, Hong‐Jai, Shin, Min‐Sun, Kang, Insoo, Kang, Min‐Jong

“…Mitochondrial dysfunction has long been implicated to have a causative role in organismal aging. A mitochondrial molecule, nucleotide‐binding domain and…”
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Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases by Kang, Min Jong

“…Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our…”
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Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis by Kim, Sang-Hun, Lee, Jung Yeon, Yoon, Chang Min, Shin, Hyeon Jun, Lee, Sei Won, Rosas, Ivan, Herzog, Erica, Dela Cruz, Charles S, Kaminski, Naftali, Kang, Min-Jong

“…Danger signals, or damage-associated molecular patterns (DAMPs), instigate mitochondrial innate immune responses wherein mitochondrial antiviral signaling…”
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NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury by Kim, Hye Rin, Kim, Mi Na, Kim, Eun Gyul, Leem, Ji Su, Baek, Seung Min, Lee, Yu Jin, Kim, Kyung Won, Kang, Min-Jong, Song, Tae Won, Sohn, Myung Hyun

“…Hyperoxia is frequently used for treating acute respiratory failure, but it can cause acute lung injury. Nucleotide-binding domain and…”
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LRR domain of NLRX1 protein delivery by dNP2 inhibits T cell functions and alleviates autoimmune encephalomyelitis by Koo, Ja-Hyun, Kim, Do-Hyun, Cha, Donghun, Kang, Min-Jong, Choi, Je-Min

“…Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system (CNS), which is a chronic progressive disease and is caused by…”
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Role of Chitinase 3-Like-1 in Interleukin-18-Induced Pulmonary Type 1, Type 2, and Type 17 Inflammation; Alveolar Destruction; and Airway Fibrosis in the Murine Lung by Kang, Min-Jong, Yoon, Chang Min, Nam, Milang, Kim, Do-Hyun, Choi, Je-Min, Lee, Chun Geun, Elias, Jack A

“…Chitinase 3-like 1 (Chi3l1), which is also called YKL-40 in humans and BRP-39 in mice, is the prototypic chitinase-like protein. Recent studies have…”
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MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury by Mannam, Praveen, Shinn, Amanda S, Srivastava, Anup, Neamu, Radu F, Walker, Wendy E, Bohanon, Michael, Merkel, Jane, Kang, Min-Jong, Dela Cruz, Charles S, Ahasic, Amy M, Pisani, Margaret A, Trentalange, Mark, West, A Phillip, Shadel, Gerald S, Elias, Jack A, Lee, Patty J

“…Sepsis is a systemic inflammatory response to infection and a major cause of death worldwide. Because specific therapies to treat sepsis are limited, and…”
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The Chitinase-like Proteins Breast Regression Protein-39 and YKL-40 Regulate Hyperoxia-induced Acute Lung Injury by MYUNG HYUN SOHN, KANG, Min-Jong, MATSUURA, Hiroshi, BHANDARI, Vineet, CHEN, Ning-Yuan, CHUN GEUN LEE, ELIAS, Jack A

“…Prolonged exposure to 100% O(2) causes hyperoxic acute lung injury (HALI), characterized by alveolar epithelial cell injury and death. We previously…”
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Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma by Koh, Byung Hee, Hwang, Soo Seok, Kim, Joo Young, Lee, Wonyong, Kang, Min-Jong, Lee, Chun Geun, Park, Jung-Won, Flavell, Richard A, Lee, Gap Ryol

“…Previous studies have shown that Th2 cytokine genes on mouse chromosome 11 are coordinately regulated by the Th2 locus control region (LCR). To examine the in…”
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The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study by Kim, Jae Yeol, Jung, Jae-Woo, Kang, Min-Jong, Kim, Deog Kyeom, Choi, Hayoung, Cho, Young-Jae, Jang, Seung Hun, Lee, Chang-Hoon, Oh, Yeon Mok, Park, Ji Sook

“…Background/Aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired…”
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Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury by Harris, Zachary M., Sun, Ying, Joerns, John, Clark, Brian, Hu, Buqu, Korde, Asawari, Sharma, Lokesh, Shin, Hyeon Jun, Manning, Edward P., Placek, Lindsey, Unutmaz, Derya, Stanley, Gail, Chun, Hyung, Sauler, Maor, Rajagopalan, Govindarajan, Zhang, Xuchen, Kang, Min-Jong, Koff, Jonathan L.

“…Aims. Studies have linked severe hyperoxia, or prolonged exposure to very high oxygen levels, with worse clinical outcomes. This study investigated the role of…”
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Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19 by Kamle, Suchitra, Ma, Bing, He, Chuan Hua, Akosman, Bedia, Zhou, Yang, Lee, Chang-Min, El-Deiry, Wafik S, Huntington, Kelsey, Liang, Olin, Machan, Jason T, Kang, Min-Jong, Shin, Hyeon Jun, Mizoguchi, Emiko, Lee, Chun Geun, Elias, Jack A

“…COVID-19 is caused by SARS-CoV-2 (SC2) and is more prevalent and severe in elderly and patients with comorbid diseases (CM). Because chitinase 3-like-1…”
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Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases by Kang, Min-Jong

“…Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our…”
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Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema by Matsuura, Hiroshi, Hartl, Dominik, Kang, Min-Jong, Dela Cruz, Charles S, Koller, Barbara, Chupp, Geoffrey L, Homer, Robert J, Zhou, Yang, Cho, Won-Kyung, Elias, Jack A, Lee, Chun Geun

“…The exaggerated expression of chitinase-like protein YKL-40, the human homologue of breast regression protein-39 (BRP-39), was reported in a number of…”
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IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension by Cho, Won-Kyung, Lee, Chang-Min, Kang, Min-Jong, Huang, Yan, Giordano, Frank J, Lee, Patty J, Trow, Terence K, Homer, Robert J, Sessa, William C, Elias, Jack A, Lee, Chun Geun

“…Although previous literature suggests that interleukin (IL)-13, a T-helper type 2 cell effector cytokine, might be involved in the pathogenesis of pulmonary…”
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