Search Results - "Kang, Liang‐I"

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function by Winkler, Emma S., Bailey, Adam L., Kafai, Natasha M., Nair, Sharmila, McCune, Broc T., Yu, Jinsheng, Fox, Julie M., Chen, Rita E., Earnest, James T., Keeler, Shamus P., Ritter, Jon H., Kang, Liang-I, Dort, Sarah, Robichaud, Annette, Head, Richard, Holtzman, Michael J., Diamond, Michael S.

“…Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung…”
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Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response by Wang, Anthony Z, Bowman-Kirigin, Jay A, Desai, Rupen, Kang, Liang-I, Patel, Pujan R, Patel, Bhuvic, Khan, Saad M, Bender, Diane, Marlin, M Caleb, Liu, Jingxian, Osbun, Joshua W, Leuthardt, Eric C, Chicoine, Michael R, Dacey, Jr, Ralph G, Zipfel, Gregory J, Kim, Albert H, DeNardo, David G, Petti, Allegra A, Dunn, Gavin P

“…Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely…”
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Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli by Norris, Callie A, He, Mu, Kang, Liang-I, Ding, Michael Qi, Radder, Josiah E, Haynes, Meagan M, Yang, Yu, Paranjpe, Shirish, Bowen, William C, Orr, Anne, Michalopoulos, George K, Stolz, Donna B, Mars, Wendy M

“…Exogenous interleukin 6 (IL-6), synthesized at the initiation of the acute phase response, is considered responsible for signaling hepatocytes to produce acute…”
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Signals and cells involved in regulating liver regeneration by Kang, Liang-I, Mars, Wendy M, Michalopoulos, George K

“…Liver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in the event of injury resulting in loss of hepatic parenchyma. Partial…”
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Systemic Alterations in Type-2 Conventional Dendritic Cells Lead to Impaired Tumor Immunity in Pancreatic Cancer by James, C Alston, Baer, John M, Zou, Chong, Panni, Usman Y, Knolhoff, Brett L, Hogg, Graham D, Kingston, Natalie L, Kang, Liang-I, Lander, Varintra E, Luo, Jingqin, Tao, Yu, Watson, Mark A, Aft, Rebecca, Fields, Ryan C, Hawkins, William G, DeNardo, David G

“…Intratumoral T-cell dysfunction is a hallmark of pancreatic tumors, and efforts to improve dendritic cell (DC)-mediated T-cell activation may be critical in…”
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Correction: Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli by Norris, Callie A., He, Mu, Kang, Liang-I, Ding, Michael Qi, Radder, Josiah E., Haynes, Meagan M., Yang, Yu, Paranjpe, Shirish, Bowen, William C., Orr, Anne, Michalopoulos, George K., Stolz, Donna B., Mars, Wendy M.

“…[This corrects the article DOI: 10.1371/journal.pone.0096053.]…”
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Chemokine Receptor 2 Targeted PET/CT Imaging Distant Metastases in Pancreatic Ductal Adenocarcinoma by Zhang, Xiaohui, Detering, Lisa, Heo, Gyu Seong, Sultan, Deborah, Luehmann, Hannah, Li, Lin, Somani, Vikas, Lesser, Josie, Tao, Joan, Kang, Liang-I., Li, Alexandria, Lahad, Divangana, Rho, Shinji, Ruzinova, Marianna B., DeNardo, David G., Dehdashti, Farrokh, Lim, Kian-Huat, Liu, Yongjian

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and treatment-refractory malignancies. The lack of an effective screening tool results in…”
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Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4‐bis [2‐(3,5‐dichloropyridyloxy)] benzene is suppressed in hepatocyte‐targeted glypican 3 transgenic mice by Lin, Chih‐Wen, Mars, Wendy M., Paranjpe, Shirish, Donthamsetty, Shashikiran, Bhave, Vishakha S., Kang, Liang‐I, Orr, Anne, Bowen, William C., Bell, Aaron W., Michalopoulos, George K.

“…Glypican 3 (GPC3) is a family of glycosylphosphatidylinositol‐anchored, cell‐surface heparan sulfate proteoglycans. Loss‐of‐function mutations of GPC3 cause…”
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Emergent parotidectomy after parotid lymphatic malformation hematoma by Bhatt, Neel K, Kang, Liang-I, El-Mofty, Samir, Nussenbaum, Brian, Pipkorn, Patrik

“…Abstract Introduction Lymphatic malformations (LM) are non-malignant, congenital masses that contain fluid-filled lymph channels. These lesions typically…”
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Fibrinolytic factors in liver fibrosis by Kang, Liang-I, Mars, Wendy M

“…Dysregulation of coagulation and fibrinolytic factors is now being recognized as not just a late-stage sequelae of liver disease, but in fact one of the…”
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Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis by Bigley, Tarin M, Yang, Liping, Kang, Liang-I, Saenz, Jose B, Victorino, Francisco, Yokoyama, Wayne M

“…Infections with herpesviruses, including human roseoloviruses, have been proposed to cause autoimmune disease, but defining a causal relationship and mechanism…”
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Estrogen stimulates female biliary epithelial cell interleukin‐6 expression in mice and humans by Isse, Kumiko, Specht, Susan M., Lunz, John G., Kang, Liang‐I, Mizuguchi, Yoshiaki, Demetris, Anthony J.

“…Females are more susceptible than males to several biliary tract diseases. Interleukin‐6 (IL‐6) is critical to triggering autoimmune reactions and contributes…”
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity by Liu, Xiuting, Hogg, Graham D., Zuo, Chong, Borcherding, Nicholas C., Baer, John M., Lander, Varintra E., Kang, Liang-I, Knolhoff, Brett L., Ahmad, Faiz, Osterhout, Robin E., Galkin, Anna V., Bruey, Jean-Marie, Carter, Laura L., Mpoy, Cedric, Vij, Kiran R., Fields, Ryan C., Schwarz, Julie K., Park, Haeseong, Gupta, Vineet, DeNardo, David G.

“…Chronic activation of inflammatory pathways and suppressed interferon are hallmarks of immunosuppressive tumors. Previous studies have shown that CD11b…”
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Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer by Herzog, Brett H, Baer, John M, Borcherding, Nicholas, Kingston, Natalie L, Belle, Jad I, Knolhoff, Brett L, Hogg, Graham D, Ahmad, Faiz, Kang, Liang-I, Petrone, Jessica, Lin, Chieh-Yu, Govindan, Ramaswamy, DeNardo, David G

“…Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune checkpoint blockade has improved survival for many patients with NSCLC,…”
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Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade by Lander, Varintra E, Belle, Jad I, Kingston, Natalie L, Herndon, John M, Hogg, Graham D, Liu, Xiuting, Kang, Liang-I, Knolhoff, Brett L, Bogner, Savannah J, Baer, John M, Zuo, Chong, Borcherding, Nicholas C, Lander, Daniel P, Mpoy, Cedric, Scott, Jalen, Zahner, Michael, Rogers, Buck E, Schwarz, Julie K, Kim, Hyun, DeNardo, David G

“…The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma (PDAC) are not well understood. To better understand if RT can prime…”
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Improving Liver Graft Function Using CD47 Blockade in the Setting of Normothermic Machine Perfusion by Garcia-Aroz, Sandra, Xu, Min, Ahmed, Ola, Hollingshead, Joshua, Wang, Xuanchuan, Banan, Babak, Khan, Adeel, Kang, Liang-I, Zhang, Zhengyan, Upadhya, Gundumi, Manning, Pamela, Lin, Yiing, Chapman, William C.

“…Toward the goal of using more livers for transplantation, transplant centers are looking to increase the use of organs from "marginal" donors. Livers from…”
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Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC by Baer, John M., Zuo, Chong, Kang, Liang-I, de la Lastra, Angela Alarcon, Borcherding, Nicholas C., Knolhoff, Brett L., Bogner, Savannah J., Zhu, Yu, Yang, Liping, Laurent, Jennifer, Lewis, Mark A., Zhang, Nan, Kim, Ki-Wook, Fields, Ryan C., Yokoyama, Wayne M., Mills, Jason C., Ding, Li, Randolph, Gwendalyn J., DeNardo, David G.

“…Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be phenotypically distinct from monocyte-derived macrophages. Whether…”
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IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma by Somani, Vikas K., Zhang, Daoxiang, Dodhiawala, Paarth B., Lander, Varintra E., Liu, Xiuting, Kang, Liang-I, Chen, Hung-Po, Knolhoff, Brett L., Li, Lin, Grierson, Patrick M., Ruzinova, Marianna B., DeNardo, David G., Lim, Kian-Huat

“…Checkpoint immunotherapy is largely ineffective in pancreatic ductal adenocarcinoma (PDAC). The innate immune nuclear factor (NF)-κB pathway promotes PDAC cell…”
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Deletion of JAM-A causes morphological defects in the corneal epithelium by Kang, Liang I., Wang, Yan, Suckow, Arthur T., Czymmek, Kirk J., Cooke, Vesselina G., Naik, Ulhas P., Duncan, Melinda K.

“…Junctional adhesion molecule-A (JAM-A, JAM-1, F11R) is an Ig domain containing transmembrane protein that has been proposed to function in diverse processes…”
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Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury by Bailey, Adam L., Kang, Liang-I, de Assis Barros D’Elia Zanella, Luiz Gonzaga Francisco, Silveira, Cássia G. T., Ho, Yeh-Li, Foquet, Lander, Bial, Greg, McCune, Broc T., Duarte-Neto, Amaro Nunes, Thomas, Archana, Raué, Hans-Peter, Byrnes, Kathleen, Kallas, Esper G., Slifka, Mark K., Diamond, Michael S.

“…Yellow fever (YF) is a mosquito-transmitted viral disease that causes tens of thousands of deaths each year despite the long-standing deployment of an…”
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