Search Results - "Kang, Hoon Chul"

Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids by Cho, Ann-Na, Jin, Yoonhee, An, Yeonjoo, Kim, Jin, Choi, Yi Sun, Lee, Jung Seung, Kim, Junghoon, Choi, Won-Young, Koo, Dong-Jun, Yu, Weonjin, Chang, Gyeong-Eon, Kim, Dong-Yoon, Jo, Sung-Hyun, Kim, Jihun, Kim, Sung-Yon, Kim, Yun-Gon, Kim, Ju Young, Choi, Nakwon, Cheong, Eunji, Kim, Young-Joon, Je, Hyunsoo Shawn, Kang, Hoon-Chul, Cho, Seung-Woo

“…Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological…”
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The use of technical replication for detection of low-level somatic mutations in next-generation sequencing by Kim, Junho, Kim, Dachan, Lim, Jae Seok, Maeng, Ju Heon, Son, Hyeonju, Kang, Hoon-Chul, Nam, Hojung, Lee, Jeong Ho, Kim, Sangwoo

“…Accurate genome-wide detection of somatic mutations with low variant allele frequency (VAF, <1%) has proven difficult, for which generalized, scalable methods…”
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Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy by Lim, Jae Seok, Kim, Woo-il, Kang, Hoon-Chul, Kim, Se Hoon, Park, Ah Hyung, Park, Eun Kyung, Cho, Young-Wook, Kim, Sangwoo, Kim, Ho Min, Kim, Jeong A, Kim, Junho, Rhee, Hwanseok, Kang, Seok-Gu, Kim, Heung Dong, Kim, Daesoo, Kim, Dong-Seok, Lee, Jeong Ho

“…Deep sequencing identifies somatic activating mutations of MTOR in affected brain regions of FCDII patients that are sufficient to cause neuronal migration…”
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Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy by Kim, Jeong A, Yoon, Jung‐Rim, Lee, Eun Joo, Lee, Joon Soo, Kim, Jeong Tae, Kim, Heung Dong, Kang, Hoon‐Chul

“…Summary Objective We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the…”
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Common genes and recurrent causative variants in 957 Asian patients with pediatric epilepsy by Kim, Se Hee, Seo, Jieun, Kwon, Soon Sung, Teng, Lip‐Yuen, Won, DongJu, Shin, Saeam, Lee, Joon Soo, Lee, Seung‐Tae, Choi, Jong Rak, Kang, Hoon‐Chul

“…Objective We aimed to identify common genes and recurrent causative variants in a large group of Asian patients with different epilepsy syndromes and…”
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Precise detection of low-level somatic mutation in resected epilepsy brain tissue by Sim, Nam Suk, Ko, Ara, Kim, Woo Kyeong, Kim, Se Hoon, Kim, Ju Seong, Shim, Kyu-Won, Aronica, Eleonora, Mijnsbergen, Caroline, Spliet, Wim G. M., Koh, Hyun Yong, Kim, Heung Dong, Lee, Joon Soo, Kim, Dong Seok, Kang, Hoon-Chul, Lee, Jeong Ho

“…Low-level somatic mutations have been shown to be the major genetic etiology of intractable epilepsy. The extents thereof, however, have yet to be…”
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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination by Park, Sang Min, Lim, Jae Seok, Ramakrishina, Suresh, Kim, Se Hoon, Kim, Woo Kyeong, Lee, Junehawk, Kang, Hoon-Chul, Reiter, Jeremy F., Kim, Dong Seok, Kim, Hyongbum (Henry), Lee, Jeong Ho

“…Focal malformations of cortical development (FMCDs), including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are major etiologies of pediatric…”
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BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors by Koh, Hyun Yong, Kim, Se Hoon, Jang, Jaeson, Kim, Hyungguk, Han, Sungwook, Lim, Jae Seok, Son, Geurim, Choi, Junjeong, Park, Byung Ouk, Heo, Won Do, Han, Jinju, Lee, Hyunjoo Jenny, Lee, Daeyoup, Kang, Hoon-Chul, Shong, Minho, Paik, Se-Bum, Kim, Dong Seok, Lee, Jeong Ho

“…Pediatric brain tumors are highly associated with epileptic seizures 1 . However, their epileptogenic mechanisms remain unclear. Here, we show that the…”
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Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia by Lim, Jae Seok, Gopalappa, Ramu, Kim, Se Hoon, Ramakrishna, Suresh, Lee, Minji, Kim, Woo-il, Kim, Junho, Park, Sang Min, Lee, Junehawk, Oh, Jung-Hwa, Kim, Heung Dong, Park, Chang-Hwan, Lee, Joon Soo, Kim, Sangwoo, Kim, Dong Seok, Han, Jung Min, Kang, Hoon-Chul, Kim, Hyongbum (Henry), Lee, Jeong Ho

“…Focal cortical dysplasia (FCD) is a major cause of the sporadic form of intractable focal epilepsies that require surgical treatment. It has recently been…”
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Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy by Kim, Jang Keun, Cho, Jun, Kim, Se Hoon, Kang, Hoon-Chul, Kim, Dong-Seok, Kim, V Narry, Lee, Jeong Ho

“…Brain somatic mutations confer genomic diversity in the human brain and cause neurodevelopmental disorders. Recently, brain somatic activating mutations in…”
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25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome by Jang, Jiho, Park, Sangjun, Jin Hur, Hye, Cho, Hyun-Ju, Hwang, Inhwa, Pyo Kang, Yun, Im, Isak, Lee, Hyunji, Lee, Eunju, Yang, Wonsuk, Kang, Hoon-Chul, Won Kwon, Sung, Yu, Je-Wook, Kim, Dong-Wook

“…X-linked adrenoleukodystrophy (X-ALD), caused by an ABCD1 mutation, is a progressive neurodegenerative disorder associated with the accumulation of very…”
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Disparate treatment outcomes according to presence of pathogenic mutations in West syndrome by Choi, Han Som, Ko, Ara, Kim, Se Hee, Lee, Seung‐Tae, Choi, Jong Rak, Lee, Joon Soo, Kim, Heung Dong, Kang, Hoon‐Chul

“…Objective It has been known that West syndrome (WS) patients with an unknown etiology have better clinical outcomes than patients with an identified etiology…”
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A decrease in the incidence of encephalitis in South Korea during the COVID‐19 pandemic: A nationwide study between 2010 and 2021 by Kim, Se Hee, Baek, Jee Yeon, Han, Minkyung, Lee, Myeongjee, Lim, Sung Min, Lee, Ji Young, Kang, Ji‐Man, Jung, Inkyung, Kang, Hoon‐Chul, Ahn, Jong Gyun

“…Limited data are available on the impact of the coronavirus disease (COVID‐19) pandemic on encephalitis. Therefore, we evaluated trends in encephalitis in…”
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Long-term efficacy and safety of adjunctive perampanel in pediatric patients aged 4–19 years with epilepsy: a real-world study by Youn, Song Ee, Kang, Hoon-Chul, Lee, Joon Soo, Kim, Heung Dong, Kim, Se Hee

“…This study determined the 24-month outcomes of perampanel treatment in children and adolescents with epilepsy. The percentage of ≥ 50% responders was 47.3%…”
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Analysis of low-level somatic mosaicism reveals stage and tissue-specific mutational features in human development by Kim, Ja Hye, Hwang, Shinwon, Son, Hyeonju, Kim, Dongsun, Kim, Il Bin, Kim, Myeong-Heui, Sim, Nam Suk, Kim, Dong-Seok, Ha, Yoo-Jin, Lee, Junehawk, Kang, Hoon-Chul, Lee, Jeong Ho, Kim, Sangwoo

“…Most somatic mutations that arise during normal development are present at low levels in single or multiple tissues depending on the developmental stage and…”
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Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) by Bonduelle, Thomas, Hartlieb, Till, Baldassari, Sara, Sim, Nam Suk, Kim, Se Hoon, Kang, Hoon-Chul, Kobow, Katja, Coras, Roland, Chipaux, Mathilde, Dorfmüller, Georg, Adle-Biassette, Homa, Aronica, Eleonora, Lee, Jeong Ho, Blumcke, Ingmar, Baulac, Stéphanie

“…Focal malformations of cortical development (MCD) are linked to somatic brain mutations occurring during neurodevelopment. Mild malformation of cortical…”
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Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome by Kang, Joon Won, Eom, Soyong, Hong, William, Kwon, Hye Eun, Park, Soyoung, Ko, Ara, Kang, Hoon-Chul, Lee, Joon Soo, Lee, Young-Mock, Kim, Dong Seok, Kim, Heung Dong

“…We aimed to evaluate the long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome (LGS). We reviewed the case reports of 90…”
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Targeted gene panel sequencing in early infantile onset developmental and epileptic encephalopathy by Na, Ji-Hoon, Shin, Saeam, Yang, Donghwa, Kim, Borahm, Kim, Heung Dong, Kim, Sehee, Lee, Joon-Soo, Choi, Jong-Rak, Lee, Seung-Tae, Kang, Hoon-Chul

“…Early-onset developmental and epileptic encephalopathy (DEE) is characterized by repeated seizures beginning within 3 months of birth and severe interictal…”
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Neuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery by Kim, Yoon Hee, Kang, Hoon‐Chul, Kim, Dong‐Seok, Kim, Se Hoon, Shim, Kyu‐Won, Kim, Heung Dong, Lee, Joon Soo

“…Summary Purpose:  The purpose of this study is to determine the sensibility of each imaging tool in identifying focal cortical dysplasia (FCD) in children and…”
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The phenotype and treatment of SCN2A‐related developmental and epileptic encephalopathy by Kim, Hyo Jeong, Yang, Donghwa, Kim, Se Hee, Kim, Borahm, Kim, Heung Dong, Lee, Joon Soo, Choi, Jong Rak, Lee, Seung‐Tae, Kang, Hoon‐Chul

“…Aims. We aimed to delineate the phenotypic spectrum of SCN2A‐related developmental and epileptic encephalopathy (DEE) and determine the effectiveness of…”
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