Search Results - "Kang, David E"

X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women by Yan, Yan, Wang, Xinming, Chaput, Dale, Shin, Min-Kyoo, Koh, Yeojung, Gan, Li, Pieper, Andrew A., Woo, Jung-A.A., Kang, David E.

“…Although women experience significantly higher tau burden and increased risk for Alzheimer’s disease (AD) than men, the underlying mechanism for this…”
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Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity by Woo, Jung-A. A., Liu, Tian, Trotter, Courtney, Fang, Cenxiao C., De Narvaez, Emillio, LePochat, Patrick, Maslar, Drew, Bukhari, Anusha, Zhao, Xingyu, Deonarine, Andrew, Westerheide, Sandy D., Kang, David E.

“…Although multiple CHCHD10 mutations are associated with the spectrum of familial and sporadic frontotemporal dementia–amyotrophic lateral sclerosis (FTD–ALS)…”
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Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+ Leak Channels by Shilling, Dustin, Mak, Don-On Daniel, Kang, David E., Foskett, J. Kevin

“…Familial Alzheimer disease (FAD) is linked to mutations in the presenilin (PS) homologs. FAD mutant PS expression has several cellular consequences, including…”
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Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation by Kee, Teresa R, Wehinger, Jessica L, Gonzalez, Pamela Espinoza, Nguyen, Eric, McGill Percy, Kyle C, Khan, Sophia A, Chaput, Dale, Wang, Xinming, Liu, Tian, Kang, David E, Woo, Jung-A A

“…Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) is a mitochondrial protein that plays important roles in cristae structure, oxidative…”
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Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion by Ren, Di, He, Zhibin, Fedorova, Julia, Zhang, Jingwen, Wood, Elizabeth, Zhang, Xiang, Kang, David E., Li, Ji

“…Sestrin2 (Sesn2) is a stress-inducible protein that declines with aging in the heart. We reported that rescue Sesn2 levels in aged mouse hearts through gene…”
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Mitochondrial CHCHD2: Disease-Associated Mutations, Physiological Functions, and Current Animal Models by Kee, Teresa R, Espinoza Gonzalez, Pamela, Wehinger, Jessica L, Bukhari, Mohammed Zaheen, Ermekbaeva, Aizara, Sista, Apoorva, Kotsiviras, Peter, Liu, Tian, Kang, David E, Woo, Jung-A A

“…Rare mutations in the mitochondrial protein coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) are associated with Parkinson's disease (PD) and…”
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Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes by Woo, Jung A, Liu, Tian, Zhao, Xingyu, Trotter, Courtney, Yrigoin, Ksenia, Cazzaro, Sara, Narvaez, Emilio De, Khan, Hirah, Witas, Richard, Bukhari, Anusha, Makati, Kamal, Wang, Xinming, Dickey, Chad, Kang, David E

“…Accumulation of amyloid β (Aβ) and tau represent the two major pathological hallmarks of Alzheimer's disease (AD). Despite the critical importance of Aβ…”
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A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity by Koo, Edward H, Weggen, Sascha, Eriksen, Jason L, Das, Pritam, Sagi, Sarah A, Wang, Rong, Pietrzik, Claus U, Findlay, Kirk A, Smith, Tawnya E, Murphy, Michael P, Bulter, Thomas, Kang, David E, Marquez-Sterling, Numa, Golde, Todd E

“…Epidemiological studies have documented a reduced prevalence of Alzheimer's disease among users of nonsteroidal anti-inflammatory drugs (NSAIDs). It has been…”
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Slingshot homolog-1 mediates the secretion of small extracellular vesicles containing misfolded proteins by regulating autophagy cargo receptors and actin dynamics by Cazzaro, Sara, Fang, Cenxiao, Khan, Hirah, Witas, Richard, Kee, Teresa R, Woo, Jung-A A, Kang, David E

“…Increasing evidence indicates that the accumulation misfolded proteins in Alzheimer's disease (AD) arises from clearance defects in the autophagy-lysosome…”
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Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10 by Liu, Tian, Woo, Jung-A A, Bukhari, Mohammed Zaheen, Wang, Xinming, Yan, Yan, Buosi, Sara Cazzaro, Ermekbaeva, Aizara, Sista, Apoorva, Kotsiviras, Peter, LePochat, Patrick, Chacko, Ann, Zhao, Xingyu, Kang, David E

“…Mutations in CHCHD10, a gene coding for a mitochondrial intermembrane space protein, are associated with Frontotemporal dementia (FTD)-Amyotrophic lateral…”
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Crystal Violet Selectively Detects Aβ Oligomers but Not Fibrils In Vitro and in Alzheimer's Disease Brain Tissue by Karunarathne, Kanchana, Kee, Teresa R, Jeon, Hanna, Cazzaro, Sara, Gamage, Yasith I, Pan, Jianjun, Woo, Jung-A A, Kang, David E, Muschol, Martin

“…Deposition of extracellular Amyloid Beta (Aβ) and intracellular tau fibrils in post-mortem brains remains the only way to conclusively confirm cases of…”
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Presenilin 1 Regulates Epidermal Growth Factor Receptor Turnover and Signaling in the Endosomal-Lysosomal Pathway by Repetto, Emanuela, Yoon, Il-Sang, Zheng, Hui, Kang, David E.

“…Mutations in the gene encoding presenilin 1 (PS1) cause the most aggressive form of early-onset familial Alzheimer disease. In addition to its well established…”
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Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes by Palavicini, Juan P, Chen, Juan, Wang, Chunyan, Wang, Jianing, Qin, Chao, Baeuerle, Eric, Wang, Xinming, Woo, Jung A, Kang, David E, Musi, Nicolas, Dupree, Jeffrey L, Han, Xianlin

“…Diabetic neuropathy is a major complication of diabetes. Current treatment options alleviate pain but do not stop the progression of the disease. At present,…”
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Clinical use of fluorodeoxyglucose F 18 positron emission tomography for detection of renal cell carcinoma by Kang, David E, White, Jr, Richard L, Zuger, James H, Sasser, Howell C, Teigland, Chris M

“…We evaluate the role of fluorodeoxyglucose F 18 positron emission tomography (PET) in patients with renal cell carcinoma (RCC) by retrospective review. To our…”
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Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics by Woo, Jung-A. A., Liu, Tian, Fang, Cenxiao C., Cazzaro, Sara, Kee, Teresa, LePochat, Patrick, Yrigoin, Ksenia, Penn, Courtney, Zhao, Xingyu, Wang, Xinming, Liggett, Stephen B., Kang, David E.

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. While the accumulation of Aβ is pivotal to the…”
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Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion by Liu, Tian, Wetzel, Liam, Zhu, Zexi, Kumaraguru, Pavan, Gorthi, Viraj, Yan, Yan, Bukhari, Mohammed Zaheen, Ermekbaeva, Aizara, Jeon, Hanna, Kee, Teresa R, Woo, Jung-A Alexa, Kang, David E

“…Coiled-coil-helix-coiled-coil-helix domain-containing 10 (CHCHD10) is a nuclear-encoded mitochondrial protein which is primarily mutated in the spectrum of…”
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Author Correction: Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics by Woo, Jung-A. A., Liu, Tian, Fang, Cenxiao C., Cazzaro, Sara, Kee, Teresa, LePochat, Patrick, Yrigoin, Ksenia, Penn, Courtney, Zhao, Xingyu, Wang, Xinming, Liggett, Stephen B., Kang, David E.

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Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression by Kwan, Patrick, Poon, Wai Sang, Ng, Ho-Keung, Kang, David E, Wong, Virginia, Ng, Ping Wing, Lui, Colin H.T, Sin, Ngai Chuen, Wong, Ka S, Baum, Larry

“…OBJECTIVESMany antiepileptic drugs (AEDs) prevent seizures by blocking voltage-gated brain sodium channels. However, treatment is ineffective in 30% of…”
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RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease by Wang, Ruizhi, Palavicini, Juan Pablo, Wang, Hongjie, Maiti, Panchanan, Bianchi, Elisabetta, Xu, Shaohua, Lloyd, B.N, Dawson-Scully, Ken, Kang, David E, Lakshmana, Madepalli K

“…Abstract We previously demonstrated that RanBP9 overexpression increased Aβ generation and amyloid plaque burden, subsequently leading to robust reductions in…”
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RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice by Palavicini, Juan Pablo, Lloyd, Brandon Noel, Hayes, Crystal D, Bianchi, Elisabetta, Kang, David E, Dawson-Scully, Ken, Lakshmana, Madepalli K

“…RanBP9 is known to act as a scaffolding protein bringing together a variety of cell surface receptors and intracellular targets thereby regulating functions as…”
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