Search Results - "Kaneto, Hideaki"

Pancreatic β-cell glucose toxicity in type 2 diabetes mellitus by Kaneto, Hideaki

“…Pancreatic β-cells secrete insulin when blood glucose levels become high. However, when β-cells are chronically exposed to hyperglycemia, their function…”
Get more information

Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History by Kaneto, Hideaki, Kimura, Tomohiko, Obata, Atsushi, Shimoda, Masashi, Kaku, Kohei

“…While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review article, we focus on metformin which is an insulin sensitizer…”
Get full text

Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better by Sanada, Junpei, Obata, Atsushi, Obata, Yoshiyuki, Fushimi, Yoshiro, Shimoda, Masashi, Kohara, Kenji, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki

“…There has been no report about the mechanism for anti-atherosclerotic effects of dulaglutide (Dula) and/or about the difference of its effectiveness between in…”
Get full text

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis by Kaneto, Hideaki, Katakami, Naoto, Matsuhisa, Munehide, Matsuoka, Taka-aki

“…Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic β-cell dysfunction and insulin…”
Get full text

Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus by Kimura, Tomohiko, Kaneto, Hideaki

“…In the presence of metformin, the c‐Jun‐NH2‐terminal kinase and p38 pathways in β‐cells are inhibited, resulting in preserved aquaporin 7 expression and…”
Get full text

Role of pancreatic transcription factors in maintenance of mature β-cell function by Kaneto, Hideaki, Matsuoka, Taka-aki

“…A variety of pancreatic transcription factors including PDX-1 and MafA play crucial roles in the pancreas and function for the maintenance of mature β-cell…”
Get full text

Comparison of the effects of three kinds of glucose‐lowering drugs on non‐alcoholic fatty liver disease in patients with type 2 diabetes: A randomized, open‐label, three‐arm, active control study by Kinoshita, Tomoe, Shimoda, Masashi, Nakashima, Koji, Fushimi, Yoshiro, Hirata, Yurie, Tanabe, Akihito, Tatsumi, Fuminori, Hirukawa, Hidenori, Sanada, Junpei, Kohara, Kenji, Irie, Shintaro, Kimura, Tomohiko, Nakamura, Yoshiko, Nishioka, Momoyo, Obata, Atsushi, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki

“…Aims/Introduction Non‐alcoholic fatty liver disease (NAFLD) is often observed in individuals with type 2 diabetes mellitus, and it is known that the presence…”
Get full text

Practical application of short-term intensive insulin therapy based on the concept of “treat to target” to reduce hypoglycaemia in routine clinical site by Nakashima, Koji, Okamura, Nobuhiro, Sanefuji, Hayato, Kaneto, Hideaki

“…The aim is to devise a new short-term intensive insulin therapy (N-SIIT) based on the concept of “treat to target” to avoid hypoglycaemia and was applied it to…”
Get full text

Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice by Fushimi, Yoshiro, Obata, Atsushi, Sanada, Junpei, Nogami, Yuka, Ikeda, Tomoko, Yamasaki, Yuki, Obata, Yoshiyuki, Shimoda, Masashi, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki

“…Effects of combination therapy of dipeptidyl peptidase-4 (DPP-4) inhibitor and sodium-glucose co-transporter 2 (SGLT2) inhibitor on β-cells are still unclear,…”
Get full text

Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules by Sanada, Junpei, Obata, Atsushi, Fushimi, Yoshiro, Kimura, Tomohiko, Shimoda, Masashi, Ikeda, Tomoko, Nogami, Yuka, Obata, Yoshiyuki, Yamasaki, Yuki, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki

“…Imeglimin is a new anti-diabetic drug commercialized in Japan (Twymeeg®) and has been drawing much attention in diabetes research area as well as in clinical…”
Get full text

Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class by Kaneto, Hideaki, Obata, Atsushi, Kimura, Tomohiko, Shimoda, Masashi, Kinoshita, Tomoe, Matsuoka, Taka-Aki, Kaku, Kohei

“…Sodium-glucose co-transporter 2 (SGLT2) inhibitors facilitate urine glucose excretion by reducing glucose reabsorption, leading to ameliorate glycemic control…”
Get full text

Clinical course of different long-acting insulin therapies—glargine U100, U300, degludec, and insulin degludec/insulin aspart—among Japanese patients with type 2 diabetes: a multicenter retrospective observational study (JDDM65 study) by Iwamoto, Masahiro, Nakanishi, Shuhei, Iwamoto, Hideyuki, Kaneto, Hideaki, Maegawa, Hiroshi, Japan Diabetes Clinical Data Management Study Group (JDDM study group)

“…This study aimed to retrospectively compare the clinical efficacy of different types of long-acting insulin therapies—glargine U100, glargine U300, degludec,…”
Get full text

Significance of body mass index for diagnosing sarcopenia is equivalent to slow gait speed in Japanese individuals with type 2 diabetes: Cross‐sectional study using outpatient clinical data by Nakanishi, Shuhei, Iwamoto, Masahiro, Shinohara, Hisanori, Iwamoto, Hideyuki, Kaneto, Hideaki

“…Aims/Introduction This study examined the association between body mass index (BMI) and the risk of sarcopenia in Japanese type 2 diabetes patients. Materials…”
Get full text

Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine by Kaneto, Hideaki, Kimura, Tomohiko, Shimoda, Masashi, Obata, Atsushi, Sanada, Junpei, Fushimi, Yoshiro, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei

“…Fundamental pancreatic β-cell function is to produce and secrete insulin in response to blood glucose levels. However, when β-cells are chronically exposed to…”
Get full text

Case Report: Markedly Long-Term Preservation of Pancreatic β-Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years by Shigemoto, Ryo, Anno, Takatoshi, Kawasaki, Fumiko, Kaku, Kohei, Kaneto, Hideaki

“…Type 1 diabetes mellitus (T1DM) is mainly triggered by autoimmune β-cell destruction, usually leading to absolute insulin deficiency. Regarding the speed of…”
Get full text

Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism by Nakashima, Koji, Kaneto, Hideaki, Shimoda, Masashi, Kimura, Tomohiko, Kaku, Kohei

“…Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion from pancreatic beta cells and suppresses glucagon secretion from alpha cells. It remains…”
Get full text

Efficacy and safety of oral semaglutide in Japanese patients with type 2 diabetes: A subgroup analysis by baseline variables in the PIONEER 9 and PIONEER 10 trials by Yabe, Daisuke, Deenadayalan, Srikanth, Horio, Hiroshi, Kaneto, Hideaki, Jensen, Thomas Bo, Terauchi, Yasuo, Yamada, Yuichiro, Inagaki, Nobuya

“…Aims/Introduction To assess the impact of baseline characteristics on the efficacy and safety of oral semaglutide in Japanese patients with type 2 diabetes…”
Get full text

Impact of sarcopenia on glycemic control and atherosclerosis in Japanese patients with type 2 diabetes: Cross‐sectional study using outpatient clinical data by Nakanishi, Shuhei, Iwamoto, Masahiro, Shinohara, Hisanori, Iwamoto, Hideyuki, Kaneto, Hideaki

“…Aim This study examined the association among sarcopenia and various surrogate markers of atherosclerosis in Japanese patients with type 2 diabetes (T2D)…”
Get full text

Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation by Ikeda, Kenta, Morizane, Shin, Akagi, Takahiko, Hiramatsu-Asano, Sumie, Tachibana, Kota, Yahagi, Ayano, Iseki, Masanori, Kaneto, Hideaki, Wada, Jun, Ishihara, Katsuhiko, Morita, Yoshitaka, Mukai, Tomoyuki

“…Patients with psoriasis are frequently complicated with metabolic syndrome; however, it is not fully understood how obesity and dyslipidemia contribute to the…”
Get full text

Influence of Nutritional Guidance/Consulting on Glycemic Control during the Coronavirus Disease 2019 Pandemic in Patients with Type 2 Diabetes Mellitus by Iwamoto, Yuichiro, Nakanishi, Shuhei, Iwamoto, Hideyuki, Sanada, Junpei, Fushimi, Yoshiro, Katakura, Yukino, Kimura, Tomohiko, Tatsumi, Fuminori, Shimoda, Masashi, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki

“…Objective The coronavirus disease 2019 (COVID-19) pandemic has led to a global restriction of public behavior due to lockdowns in various major cities…”
Get full text