Search Results - "Kane, Patricia M."

Human V-ATPase a-subunit isoforms bind specifically to distinct phosphoinositide phospholipids by Mitra, Connie, Winkley, Samuel, Kane, Patricia M.

“…Vacuolar H+-ATPases (V-ATPases) are highly conserved multisubunit enzymes that maintain the distinct pH of eukaryotic organelles. The integral membrane…”
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The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H+-ATPase by KANE, Patricia M

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids by Banerjee, Subhrajit, Kane, Patricia M.

“…Luminal pH and the distinctive distribution of phosphatidylinositol phosphate (PIP) lipids are central identifying features of organelles in all eukaryotic…”
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Targeting reversible disassembly as a mechanism of controlling V-ATPase activity by Kane, Patricia M

“…Vacuolar proton-translocating ATPases (V-ATPases) are highly conserved proton pumps consisting of a peripheral membrane subcomplex called V1, which contains…”
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Loss of Vacuolar H+-ATPase Activity in Organelles Signals Ubiquitination and Endocytosis of the Yeast Plasma Membrane Proton pump Pma1p by Smardon, Anne M., Kane, Patricia M.

“…Yeast mutants lacking the intracellular V-ATPase proton pump (vma mutants) have reduced levels of the Pma1p proton pump at the plasma membrane and increased…”
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Crystal structure of yeast V1-ATPase in the autoinhibited state by Oot, Rebecca A, Kane, Patricia M, Berry, Edward A, Wilkens, Stephan

“…Vacuolar ATPases (V‐ATPases) are essential proton pumps that acidify the lumen of subcellular organelles in all eukaryotic cells and the extracellular space in…”
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The long physiological reach of the yeast vacuolar H+-ATPase by Kane, Patricia M

“…V-ATPases are structurally conserved and functionally versatile proton pumps found in all eukaryotes. The yeast V-ATPase has emerged as a major model system,…”
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The cytosolic N-terminal domain of V-ATPase a-subunits is a regulatory hub targeted by multiple signals by Tuli, Farzana, Kane, Patricia M

“…Vacuolar H -ATPases (V-ATPases) acidify several organelles in all eukaryotic cells and export protons across the plasma membrane in a subset of cell types…”
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Regulation of Vacuolar Proton-translocating ATPase Activity and Assembly by Extracellular pH by Diakov, Theodore T., Kane, Patricia M.

“…Vacuolar proton-translocating ATPases (V-ATPases) are responsible for organelle acidification in all eukaryotic cells. The yeast V-ATPase, known to be…”
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RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification by Jaskolka, Michael C., Winkley, Samuel R., Kane, Patricia M.

“…The yeast RAVE (Regulator of H + -ATPase of Vacuolar and Endosomal membranes) complex and Rabconnectin-3 complexes of higher eukaryotes regulate acidification…”
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Some assembly required: Contributions of Tom Stevens' lab to the V‐ATPase field by Graham, Laurie A., Finnigan, Gregory C., Kane, Patricia M.

“…Tom Stevens' lab has explored the subunit composition and assembly of the yeast V‐ATPase for more than 30 years. Early studies helped establish yeast as the…”
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The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast by Smardon, Anne M, Diab, Heba I, Tarsio, Maureen, Diakov, Theodore T, Nasab, Negin Dehdar, West, Robert W, Kane, Patricia M

“…The regulator of ATPase of vacuoles and endosomes (RAVE) complex is implicated in vacuolar H(+)-translocating ATPase (V-ATPase) assembly and activity. In…”
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Editorial: Intracellular Molecular Processes Affected by pH by Antosiewicz, Jan M, Kane, Patricia M

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RAVE Is Essential for the Efficient Assembly of the C Subunit with the Vacuolar H+-ATPase by Smardon, Anne M., Kane, Patricia M.

“…The RAVE complex is required for stable assembly of the yeast vacuolar proton-translocating ATPase (V-ATPase) during both biosynthesis of the enzyme and…”
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Loss of Vacuolar Proton-translocating ATPase Activity in Yeast Results in Chronic Oxidative Stress by Milgrom, Elena, Diab, Heba, Middleton, Frank, Kane, Patricia M.

“…Yeast mutants lacking vacuolar proton-translocating ATPase (V-ATPase) subunits (vma mutants) were sensitive to several different oxidants in a recent genomic…”
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Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways by Brost, Renée L, Li, Zhijian, Hughes, Timothy R, Brown, Grant W, Ding, Huiming, Sheikh, Bilal, Parsons, Ainslie B, Kane, Patricia M, Zhang, Chaoying, Boone, Charles

“…Bioactive compounds can be valuable research tools and drug leads, but it is often difficult to identify their mechanism of action or cellular target. Here we…”
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Structure of the Yeast Vacuolar ATPase by Zhang, Zhenyu, Zheng, Yesha, Mazon, Hortense, Milgrom, Elena, Kitagawa, Norton, Kish-Trier, Erik, Heck, Albert J.R., Kane, Patricia M., Wilkens, Stephan

“…The subunit architecture of the yeast vacuolar ATPase (V-ATPase) was analyzed by single particle transmission electron microscopy and electrospray ionization…”
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Consequences of Loss of Vph1 Protein-containing Vacuolar ATPases (V-ATPases) for Overall Cellular pH Homeostasis by Tarsio, Maureen, Zheng, Huimei, Smardon, Anne M., Martínez-Muñoz, Gloria A., Kane, Patricia M.

“…In yeast cells, subunit a of the vacuolar proton pump (V-ATPase) is encoded by two organelle-specific isoforms, VPH1 and STV1. V-ATPases containing Vph1 and…”
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Cardiolipin mediates cross-talk between mitochondria and the vacuole by Chen, Shuliang, Tarsio, Maureen, Kane, Patricia M, Greenberg, Miriam L

“…Cardiolipin (CL) is an anionic phospholipid with a dimeric structure predominantly localized in the mitochondrial inner membrane, where it is closely…”
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Subunit Interactions and Requirements for Inhibition of the Yeast V1-ATPase by Diab, Heba, Ohira, Masashi, Liu, Mali, Cobb, Ester, Kane, Patricia M.

“…Disassembly of the yeast V-ATPase into cytosolic V1 and membrane V0 sectors inactivates MgATPase activity of the V1-ATPase. This inactivation requires the V1 H…”
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