Search Results - "Kane, Michael F."

Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2 by Meijer, Dimphna H., Kane, Michael F., Mehta, Shwetal, Liu, Hongye, Harrington, Emily, Taylor, Christopher M., Stiles, Charles D., Rowitch, David H.

“…Despite their structural similarities and seemingly coordinated expression patterns, oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 have largely…”
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The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma by Mehta, Shwetal, Huillard, Emmanuelle, Kesari, Santosh, Maire, Cecile L., Golebiowski, Diane, Harrington, Emily P., Alberta, John A., Kane, Michael F., Theisen, Matthew, Ligon, Keith L., Rowitch, David H., Stiles, Charles D.

“…High-grade gliomas are notoriously insensitive to radiation and genotoxic drugs. Paradoxically, the p53 gene is structurally intact in the majority of these…”
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Phosphorylation State of Olig2 Regulates Proliferation of Neural Progenitors by Sun, Yu, Meijer, Dimphna H., Alberta, John A., Mehta, Shwetal, Kane, Michael F., Tien, An-Chi, Fu, Hui, Petryniak, Magdalena A., Potter, Gregory B., Liu, Zijing, Powers, James F., Runquist, I. Sophie, Rowitch, David H., Stiles, Charles D.

“…The bHLH transcription factors that regulate early development of the central nervous system can generally be classified as either antineural or proneural…”
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Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility by Wei, Kaichun, Clark, Alan B, Wong, Edmund, Kane, Michael F, Mazur, Dan J, Parris, Tchaiko, Kolas, Nadine K, Russell, Robert, Hou, Jr, Harry, Kneitz, Burkhard, Yang, Guohze, Kunkel, Thomas A, Kolodner, Richard D, Cohen, Paula E, Edelmann, Winfried

“…Exonuclease 1 (Exo1) is a 5'-3' exonuclease that interacts with MutS and MutL homologs and has been implicated in the excision step of DNA mismatch repair. To…”
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Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice by Kolodner, Richard D, Edelmann, Winfried, Wang, Yuxun, Putnam, Christopher D, Kane, Michael F, Zhang, Weijia, Edelmann, Lisa, Russell, Robert, Carrión, Danaise V, Chin, Lynda, Kucherlapati, Raju

“…Most cancers have multiple chromosomal rearrangements; the molecular mechanisms that generate them remain largely unknown. Mice carrying a heterozygous…”
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hMSH2 Forms Specific Mispair-Binding Complexes with hMSH3 and hMSH6 by Acharya, Samir, Wilson, Teresa, Gradia, Scott, Kane, Michael F., Guerrette, Shawn, Marsischky, Gerald T., Kolodner, Richard, Fishel, Richard

“…The genetic and biochemical properties of three human MutS homologues, hMSH2, hMSH3, and hMSH6, have been examined. The full-length hMSH6 cDNA and genomic…”
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Haploinsufficiency of Flap Endonuclease (Fen1) Leads to Rapid Tumor Progression by Kucherlapati, Melanie, Yang, Kan, Kuraguchi, Mari, Zhao, Jie, Lia, Maria, Heyer, Joerg, Kane, Michael F., Fan, Kunhua, Russell, Robert, Anthony M. C. Brown, Kneitz, Burkhard, Edelmann, Winfried, Kolodner, Richard D., Lipkin, Martin, Kucherlapati, Raju

“…Flap endonuclease (Fen1) is required for DNA replication and repair, and defects in the gene encoding Fen1 cause increased accumulation of mutations and genome…”
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Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae by Hu, Yanhui, Rolfs, Andreas, Bhullar, Bhupinder, Murthy, Tellamraju V S, Zhu, Cong, Berger, Michael F, Camargo, Anamaria A, Kelley, Fontina, McCarron, Seamus, Jepson, Daniel, Richardson, Aaron, Raphael, Jacob, Moreira, Donna, Taycher, Elena, Zuo, Dongmei, Mohr, Stephanie, Kane, Michael F, Williamson, Janice, Simpson, Andrew, Bulyk, Martha L, Harlow, Edward, Marsischky, Gerald, Kolodner, Richard D, LaBaer, Joshua

“…The availability of an annotated genome sequence for the yeast Saccharomyces cerevisiae has made possible the proteome-scale study of protein function and…”
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Mutation in the mismatch repair gene Msh6 causes cancer susceptibility by Edelmann, W, Yang, K, Umar, A, Heyer, J, Lau, K, Fan, K, Liedtke, W, Cohen, P E, Kane, M F, Lipford, J R, Yu, N, Crouse, G F, Pollard, J W, Kunkel, T, Lipkin, M, Kolodner, R, Kucherlapati, R

“…Mice carrying a null mutation in the mismatch repair gene Msh6 were generated by gene targeting. Cells that were homozygous for the mutation did not produce…”
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An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells by Meijer, Dimphna H, Sun, Yu, Liu, Tao, Kane, Michael F, Alberta, John A, Adelmant, Guillaume, Kupp, Robert, Marto, Jarrod A, Rowitch, David H, Nakatani, Yoshihiro, Stiles, Charles D, Mehta, Shwetal

“…The bHLH transcription factor Olig2 is expressed in cycling neural progenitor cells but also in terminally differentiated, myelinating oligodendrocytes…”
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Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines by KANE, M. F, LODA, M, GAIDA, G. M, LIPMAN, J, MISHRA, R, GOLDMAN, H, JESSUP, J. M, KOLODNER, R

“…Somatic mutations in DNA mismatch repair genes have been observed in sporadic tumors as well as cell lines and xenografts derived from such tumors implicating…”
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MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice by Kneitz, B, Cohen, P E, Avdievich, E, Zhu, L, Kane, M F, Hou, Jr, H, Kolodner, R D, Kucherlapati, R, Pollard, J W, Edelmann, W

“…Msh4 (MutS homolog 4) is a member of the mammalian mismatch repair gene family whose members are involved in postreplicative DNA mismatch repair as well as in…”
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Incidence and Functional Consequences of hMLH1 Promoter Hypermethylation in Colorectal Carcinoma by Herman, James G., Umar, Asad, Polyak, Kornelia, Graff, Jeremy R., Ahuja, Nita, Issa, Jean-Pierre J., Markowitz, Sanford, James K. V. Willson, Hamilton, Stanley R., Kinzler, Kenneth W., Kane, Michael F., Kolodner, Richard D., Vogelstein, Bert, Kunkel, Thomas A., Baylin, Stephen B.

“…Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that…”
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Germ-line msh6 mutations in colorectal cancer families by KOLODNER, R. D, TYTELL, J. D, GARBER, J. E, SYNGAL, S, ANTON-CULVER, H, LI, F. P, SCHMEITS, J. L, KANE, M. F, GUPTA, R. D, WEGER, J, WAHLBERG, S, FOX, E. A, PEEL, D, ZIOGAS, A

“…Hereditary nonpolyposis colorectal carcinoma (HNPCC) is due primarily to inherited mutations in two mismatch repair genes, MSH2 and MLH1, whereas germ-line…”
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Identification and Characterization of Saccharomyces cerevisiae EXO1, a Gene Encoding an Exonuclease that Interacts with MSH2 by Tishkoff, Daniel X., Boerger, Adrienne L., Bertrand, Pascale, Filosi, Nicole, Gaida, Gretchen M., Kane, Michael F., Kolodner, Richard D.

“…A two-hybrid screen was used to identify Saccharomyces cerevisiae genes encoding proteins that interact with MSH2. One gene was found to encode a homologue of…”
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Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations by Kolodner, R D, Hall, N R, Lipford, J, Kane, M F, Rao, M R, Morrison, P, Wirth, L, Finan, P J, Burn, J, Chapman, P

“…Hereditary nonpolyposis colorectal carcinoma (HNPCC) is a major cancer susceptibility syndrome known to be caused by inheritance of mutations in genes such as…”
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Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA by Alani, Eric, Lee, Suman, Kane, Michael F, Griffith, Jack, Kolodner, Richard D

“…Genetic and biochemical studies have suggested that mismatch repair proteins interact with recombination intermediates to prevent recombina tion, or to limit…”
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A human compound heterozygote for two MLH1 missense mutations by Hackman, Peter, Tannergård, Pia, Osei-Mensa, Salome, Chen, Jindong, Kane, Michael F, Kolodner, Richard, Lambert, Bo, Hellgren, Dennis, Lindblom, Annika

“…Hereditary nonpolyposis colorectal cancer (HNPCC) is associated with germline mutations in MLH1 and MSH2, which are active in DNA mismatch repair (MMR)…”
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An Exploratory Analysis of Stop the Demand – Waco Program by Kane, Michael F

“…Much research on prostitution focuses on the general morality of this phenomenon. Currently, many local entities are attempting to control, reduce or eliminate…”
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Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer by Verma, L, Kane, M F, Brassett, C, Schmeits, J, Evans, D G, Kolodner, R D, Maher, E R

“…Germline mutations in the MSH2 and MLH1 mismatch repair genes account for most cases of hereditary non-polyposis colon cancer syndrome (HNPCC). In addition,…”
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