Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature

Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature

Previous studies with continuous glucose monitoring in mice have been limited to several days or weeks, with the mouse's physical attachment to the equipment affecting behavior and measurements. In the current study, we measured blood glucose and body temperature at 10-second intervals for 12 w...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) Vol. 158; no. 9; pp. 2707 - 2712
Main Authors: Korstanje, Ron, Ryan, Jennifer L, Savage, Holly S, Lyons, Bonnie L, Kane, Kevin G, Sukoff Rizzo, Stacey J
Format: Journal Article
Language:English
Published: Washington, DC Endocrine Society 01-09-2017
Oxford University Press
Subjects:
Animal models
Animals
Blood
Blood glucose
Blood Glucose - analysis
Body temperature
Body Temperature - physiology
Circadian Rhythm - physiology
Circadian rhythms
Correlation analysis
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Disease Progression
Diurnal
Endocrinology
Female
Females
Glucose
Glucose monitoring
Glucose Tolerance Test
Historical account
Hyperglycemia
Hyperglycemia - metabolism
Hyperglycemia - pathology
Intervals
Mice
Mice, Inbred NOD
Monitoring
Mouse devices
Nocturnal
Technical Communication
Telemedicine
Telemetry
Telemetry - methods
Temperature effects
Wireless Technology
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Summary:Previous studies with continuous glucose monitoring in mice have been limited to several days or weeks, with the mouse's physical attachment to the equipment affecting behavior and measurements. In the current study, we measured blood glucose and body temperature at 10-second intervals for 12 weeks in a cohort of NOD/ShiLtJ female mice using wireless telemetry. This allowed us to obtain a high-resolution profile of the circadian rhythm of these two parameters and the onset of hyperglycemic development in real time. The most striking observations were the elevated nocturnal concentrations of glucose into the diabetic range days before elevations in diurnal glucose (when glucose concentrations are historically measured) and the strong, negative correlation between elevated blood glucose concentrations and body temperature with a steady decline of the body temperature with diabetes development. Taken together, this technological advancement provides improved resolution in the study of the disease trajectory of diabetes in mouse models, including relevant translatability to the current technologies of continuous glucose monitoring now regularly used in patients.This study measured blood glucose and body temperature at 10-second intervals for 12 weeks in NOD/ShiLtJ female mice by using wireless telemetry and showed a negative correlation between the two parameters.
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ISSN:0013-7227
1945-7170
DOI:10.1210/en.2017-00266