Search Results - "Kane, JR"

Identification of Selective Imidazopyridine CSF1R Inhibitors by Kane, John L., Asmussen, Gary, Batchelor, Joseph, Cromwell, Mandy, Fezoui, Malika, Fitzgerald, Maria, Giese, Barret, Gladysheva, Tatiana, Holley, Stephanie, Keefe, Kelly, Kothe, Michael, Lam, Becky, Lim, Sungtaek, Liu, Jinyu, Ma, Liang, Metz, Markus, Scholte, Andrew A., Shum, Patrick, Wei, LinLi, Woodworth, Lisa, Edling, Andrea

“…Colony stimulating factor-1 receptor (CSF1R or c-FMS), a class III receptor tyrosine kinase expressed on members of the mononuclear phagocyte system (MPS),…”
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A bifunctional colchicinoid that binds to the androgen receptor by Sharifi, Nima, Hamel, Ernest, Lill, Markus A, Risbood, Prabhakar, Kane, Jr, Charles T, Hossain, Md Tafazzal, Jones, Amanda, Dalton, James T, Farrar, William L

“…Castrate-resistant prostate cancer (CRPC) continues to be dependent on the androgen receptor (AR) for disease progression. We have synthesized and evaluated a…”
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The Simultaneous Inhibition of Solute Carrier Family 6 Member 19 and Breast Cancer Resistance Protein Transporters Leads to an Increase of Indoxyl Sulfate (a Uremic Toxin) in Plasma and Kidney by Wang, Qingping, Munteanu, Bogdan, Marker, Alexander, Luo, Yongyi, Holz, Constanze, Kane, John L., Kuntzweiler, Theresa, Poulton, Emma-Jane, Sedic, Maja, Jayyosi, Zaid, Riedel, Jens, Fretland, Jennifer

“…Solute carrier family 6 member 19 (SLC6A19) inhibitors are being studied as therapeutic agents for phenylketonuria. In this work, a potent SLC6A19 inhibitor…”
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The simultaneous inhibition of SLC6A19 and BCRP transporters leads to an increase of indoxyl sulfate (a uremic toxin) in plasma and kidney by Wang, Qingping, Munteanu, Bogdan, Marker, Alexander, Luo, Yongyi, Holz, Constanze, Kane, Jr, John L, Kuntzweiler, Theresa, Poulton, Emma-Jane, Sedic, Maja, Jayyosi, Zaid, Riedel, Jens, Fretland, Jennifer

“…SLC6A19 inhibitors are being studied as therapeutic agents for Phenylketonuria. In this work, a potent SLC6A19 inhibitor (RA836) elevated rat kidney uremic…”
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CSF-1R Inhibition Results in Protection of Axonal Degeneration and Demyelination in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis (P5.327) by Edling, Andrea, Mahan, Amy, Woodworth, Lisa, Garron, Tracy, Kane Jr, John, Roberts, Bruce, Siders, William

“…Abstract only…”
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Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases by Lu, Jiamo, Risbood, Prabhakar, Kane, Charles T., Hossain, Md Tafazzal, Anderson, Larry, Hill, Kimberly, Monks, Anne, Wu, Yongzhong, Antony, Smitha, Juhasz, Agnes, Liu, Han, Jiang, Guojian, Harris, Erik, Roy, Krishnendu, Meitzler, Jennifer L., Konaté, Mariam, Doroshow, James H.

“…[Display omitted] The NADPH oxidases (NOXs) play a recognized role in the development and progression of inflammation-associated disorders, as well as cancer…”
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A Solid Supported Membrane-Based Technology for Electrophysical Screening of B 0 AT1-Modulating Compounds by Gerbeth-Kreul, Carolin, Pommereau, Antje, Ruf, Sven, Kane, Jr, John L, Kuntzweiler, Theresa, Hessler, Gerhard, Engel, Christian K, Shum, Patrick, Wei, LinLi, Czech, Joerg, Licher, Thomas

“…Classical high-throughput screening (HTS) technologies for the analysis of ionic currents across biological membranes can be performed using…”
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Discovery of novel sphingosine kinase-1 inhibitors. Part 2 by Xiang, Yibin, Hirth, Bradford, Kane, John L., Liao, Junkai, Noson, Kevin D., Yee, Christopher, Asmussen, Gary, Fitzgerald, Maria, Klaus, Christine, Booker, Michael

“…Working off the previously discovered sphingosine kinase-1 (SK1) inhibitor 4, structural optimization resulted in identification of a new series of analogs…”
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Discovery of novel sphingosine kinase 1 inhibitors by Xiang, Yibin, Asmussen, Gary, Booker, Michael, Hirth, Bradford, Kane, John L., Liao, Junkai, Noson, Kevin D., Yee, Christopher

“…Potent and novel sphingosine kinase 1 (SK1) inhibitor (12aa) have been discovered through a series of modifications of sphingosine, the substrate of this…”
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Enoxaparin thromboprophylaxis in gastric bypass patients: extended duration, dose stratification, and antifactor Xa activity by Borkgren-Okonek, Marilyn J., A.P.N., M.S, Hart, Robert W., M.D, Pantano, John E., M.D, Rantis, Peter C., M.D, Guske, Paul J., M.D, Kane, James M., M.D, Gordon, Nancy, M.S, Sambol, Nancy C., Pharm.D

“…Abstract Background Morbidly obese patients undergoing gastric bypass surgery are at risk for postoperative venous thromboembolism. Evidence-based…”
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Use of epidural and peripheral nerve blocks at the end of life in children and young adults with cancer: the collaboration between a pain service and a palliative care service by ANGHELESCU, DORALINA L., FAUGHNAN, LANE G., BAKER, JUSTIN N., YANG, JIE, KANE, JAVIER R.

“…Summary Background:  Clinicians may avoid continuous pain blocks in pediatric cancer patients at the end of life for fear of complications or of interfering…”
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Optimizing Inflammatory Bowel Disease for Successful In Vitro Fertilization by Pan, Jason J, Cannon, Mora, Kane, Jr, Edward, Konijeti, Gauree

“…We present a nulliparous woman with mild to moderate ulcerative colitis (UC) and multiple failed cycles of in vitro fertilization (IVF) in whom we achieved a…”
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Ring Expansion-Annulation Strategy for the Synthesis of Substituted Azulenes and Oligoazulenes. 2. Synthesis of Azulenyl Halides, Sulfonates, and Azulenylmetal Compounds and Their Application in Transition-Metal-Mediated Coupling Reactions by Crombie, Aimee L, Kane, John L, Shea, Kevin M, Danheiser, Rick L

“…A “ring expansion-annulation strategy” for the synthesis of substituted azulenes is described based on the reaction of β‘-bromo-α-diazo ketones with rhodium…”
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Abstract 27P: Rapid Behavioral Recovery After Sciatic Nerve Transection Achieved by Axonal Reconnection With Polyethylene Glycol and Methylene Blue by Keating, CP, Britt, JM, Kane, JR, Zuzek, A, Bittner, GD, Winograd, JM

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Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria by KANE, John L, HIRTH, Bradford H, BEIRONG LIANG, GOURLIE, Brian B, NAHILL, Sharon, BARSOMIAN, Gary

“…Ureas of 5-aminopyrazole and 2-aminothiazole emerged as lead compounds from a high-throughput screen assaying the growth of Staphylococcus aureus…”
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Synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt by Risbood, Prabhakar A., Kane, Charles T., Hossain, Md. Tafazzal, Vadapalli, Sudhakarrao, Chadda, Satish K.

“…First synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt is reported. First synthesis of gemcitabine triphosphate (dFdCTP) as a…”
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Yes We Can: Eating Healthy on a Limited Budget by Jetter, Karen M., Adkins, Jennymae, Cortez, Susie, Hopper, Gesford Kane, Shively, Vicki, Styne, Dennis M.

“…This study determined how people who live in low-income households can consume an affordable, nutritious diet. A community-based participatory research (CBPR)…”
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A Ring Expansion−Annulation Strategy for the Synthesis of Substituted Azulenes. Preparation and Suzuki Coupling Reactions of 1-Azulenyl Triflates by Kane, John L, Shea, Kevin M, Crombie, Aimee L, Danheiser, Rick L

“…A new strategy for the synthesis of substituted azulenes is reported, based on the reaction of β‘-bromo-α-diazo ketones with rhodium carboxylates. The key…”
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Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport by Hirth, Bradford H., Qiao, Shuang, Cuff, Lisa M., Cochran, Brian M., Pregel, Marko J., Gregory, Jill S., Sneddon, Scott F., Kane, John L.

“…A series of compounds based on the 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamide core structure are reported as potent enhancers of CFTR mediated…”
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A multiplex RT-PCR assay for the detection of chimeric transcripts encoded by the risk-stratifying translocations of pediatric acute lymphoblastic leukemia by SCURTO, P, ROCHA, M. H, KANE, J. R, WILLIAMS, W. K, HANEY, D. M, CONN, W. P, SHURTLEFF, S. A, DOWNING, J. R

“…Modern therapy for pediatric acute lymphoblastic leukemia (ALL) is based on the principle of risk stratification. One of the most important laboratory features…”
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