Search Results - "Kane, E"

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases by Kane, Alice E, Sinclair, David A

“…The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7) are thought to be responsible, in large part, for the cardiometabolic…”
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Sex differences in frailty: Comparisons between humans and preclinical models by Kane, Alice E., Howlett, Susan E.

“…•Clinical studies show that women are frailer than men, although they live longer.•Similar sex differences in frailty are seen in many preclinical models.•This…”
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Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell? by Ward, Mark P, E Kane, Laura, A Norris, Lucy, Mohamed, Bashir M, Kelly, Tanya, Bates, Mark, Clarke, Andres, Brady, Nathan, Martin, Cara M, Brooks, Robert D, Brooks, Doug A, Selemidis, Stavros, Hanniffy, Sean, Dixon, Eric P, A O'Toole, Sharon, J O'Leary, John

“…Cancer cells that transit from primary tumours into the circulatory system are known as circulating tumour cells (CTCs). These cancer cells have unique…”
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Loss of epigenetic information as a cause of mammalian aging by Yang, Jae-Hyun, Hayano, Motoshi, Griffin, Patrick T., Amorim, João A., Bonkowski, Michael S., Apostolides, John K., Salfati, Elias L., Blanchette, Marco, Munding, Elizabeth M., Bhakta, Mital, Chew, Yap Ching, Guo, Wei, Yang, Xiaojing, Maybury-Lewis, Sun, Tian, Xiao, Ross, Jaime M., Coppotelli, Giuseppe, Meer, Margarita V., Rogers-Hammond, Ryan, Vera, Daniel L., Lu, Yuancheng Ryan, Pippin, Jeffrey W., Creswell, Michael L., Dou, Zhixun, Xu, Caiyue, Mitchell, Sarah J., Das, Abhirup, O’Connell, Brendan L., Thakur, Sachin, Kane, Alice E., Su, Qiao, Mohri, Yasuaki, Nishimura, Emi K., Schaevitz, Laura, Garg, Neha, Balta, Ana-Maria, Rego, Meghan A., Gregory-Ksander, Meredith, Jakobs, Tatjana C., Zhong, Lei, Wakimoto, Hiroko, El Andari, Jihad, Grimm, Dirk, Mostoslavsky, Raul, Wagers, Amy J., Tsubota, Kazuo, Bonasera, Stephen J., Palmeira, Carlos M., Seidman, Jonathan G., Seidman, Christine E., Wolf, Norman S., Kreiling, Jill A., Sedivy, John M., Murphy, George F., Green, Richard E., Garcia, Benjamin A., Berger, Shelley L., Oberdoerffer, Philipp, Shankland, Stuart J., Gladyshev, Vadim N., Ksander, Bruce R., Pfenning, Andreas R., Rajman, Luis A., Sinclair, David A.

“…All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over…”
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Reprogramming to recover youthful epigenetic information and restore vision by Lu, Yuancheng, Brommer, Benedikt, Tian, Xiao, Krishnan, Anitha, Meer, Margarita, Wang, Chen, Vera, Daniel L., Zeng, Qiurui, Yu, Doudou, Bonkowski, Michael S., Yang, Jae-Hyun, Zhou, Songlin, Hoffmann, Emma M., Karg, Margarete M., Schultz, Michael B., Kane, Alice E., Davidsohn, Noah, Korobkina, Ekaterina, Chwalek, Karolina, Rajman, Luis A., Church, George M., Hochedlinger, Konrad, Gladyshev, Vadim N., Horvath, Steve, Levine, Morgan E., Gregory-Ksander, Meredith S., Ksander, Bruce R., He, Zhigang, Sinclair, David A.

“…Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts…”
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Novel feature selection methods for construction of accurate epigenetic clocks by Li, Adam, Mueller, Amber, English, Brad, Arena, Anthony, Vera, Daniel, Kane, Alice E, Sinclair, David A

“…Epigenetic clocks allow us to accurately predict the age and future health of individuals based on the methylation status of specific CpG sites in the genome…”
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When the Source of Flooding Matters: Divergent Responses in Carbon Fluxes in an Alaskan Rich Fen to Two Types of Inundation by Euskirchen, E. S., Kane, E. S., Edgar, C. W., Turetsky, M. R.

“…The extent of groundwater-influenced rich fens is increasing across northern regions as permafrost thaws. The increase in the extent of these fens, which store…”
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Age and life expectancy clocks based on machine learning analysis of mouse frailty by Schultz, Michael B., Kane, Alice E., Mitchell, Sarah J., MacArthur, Michael R., Warner, Elisa, Vogel, David S., Mitchell, James R., Howlett, Susan E., Bonkowski, Michael S., Sinclair, David A.

“…The identification of genes and interventions that slow or reverse aging is hampered by the lack of non-invasive metrics that can predict the life expectancy…”
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Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index by Kane, Alice E, Hilmer, Sarah N, Boyer, Dawn, Gavin, Kristan, Nines, Dawn, Howlett, Susan E, de Cabo, Rafael, Mitchell, Sarah J

“…This article investigates the effect on the mouse frailty index (FI), of factors known to influence lifespan and healthspan in mice: strain (short-lived DBA/2J…”
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Using Lean Six Sigma implied assumptions by Kane, Victor E

“…PurposeThe intent of this work is to state the implied assumptions that define the setting for using a Lean Six Sigma (LSS) business strategy to conduct…”
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Multifunctional Structures and Multistructural Functions: Integration in the Evolution of Biomechanical Systems by Farina, S C, Kane, E A, Hernandez, L P

“…Abstract Integration is an essential feature of complex biomechanical systems, with coordination and covariation occurring among and within structural…”
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Fuel availability not fire weather controls boreal wildfire severity and carbon emissions by Walker, X J, Rogers, B M, Veraverbeke, S, Johnstone, J F, Baltzer, J L, Barrett, K, Bourgeau-Chavez, L, Day, N J, Groot, W J de, Dieleman, C M, Goetz, S, Hoy, E, Jenkins, L K, Kane, E S, Parisien, M -A, Potter, S, Schuur, E A G, Turetsky, M, Whitman, E, Mack, M C

“…Carbon (C) emissions from wildfires are a key terrestrial–atmosphere interaction that influences global atmospheric composi-tion and climate. Positive…”
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Biting kinematics do not differ between ecologically divergent populations of Trinidadian guppies by Cohen, H. E., Kane, E. A.

“…Performance, the ability to complete an ecologically relevant task, serves as a link between underlying morphology and the maximum functional capacity and…”
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A silicon-based nuclear spin quantum computer by Kane, B. E

“…Here I present a scheme for Implementing a quantum-mechanical computer. Information is encoded onto the nuclear spins of donor atoms in doped silicon…”
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Sustained Delivery Fluocinolone Acetonide Vitreous Inserts Provide Benefit for at Least 3 Years in Patients with Diabetic Macular Edema by Campochiaro, Peter A., MD, Brown, David M., MD, Pearson, Andrew, MD, Chen, Sanford, MD, Boyer, David, MD, Ruiz-Moreno, Jose, MD, Garretson, Bruce, MD, Gupta, Amod, MD, Hariprasad, Seenu M., MD, Bailey, Clare, MD, Reichel, Elias, MD, Soubrane, Gisele, MD, Kapik, Barry, MS, Billman, Kathleen, BS, Kane, Frances E., PhD, Green, Kenneth, PhD

“…Objective To assess long-term efficacy and safety of intravitreal inserts releasing 0.2 μg/d (low dose) or 0.5 μg/d (high dose) fluocinolone acetonide (FAc) in…”
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Whole-fat dairy products do not adversely affect adiposity or cardiometabolic risk factors in children in the Milky Way Study: a double-blind randomized controlled pilot study by Nicholl, Analise, Deering, Kane E, Evelegh, Kate, Lyons-Wall, Philippa, Lawrence, David, Mori, Trevor A, Kratz, Mario, O’Sullivan, Therese A

“…Limited evidence supports the common public health guideline that children >2 y of age should consume dairy with reduced fat content. We aimed to investigate…”
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Converging neural and behavioral evidence for a rapid, generalized response to threat-related facial expressions in 3-year-old children by Xie, Wanze, Leppänen, Jukka M., Kane-Grade, Finola E., Nelson, Charles A.

“…•Children's ERP and behavioral responses to facial expressions converge on an enhanced response to threat-related (i.e., fearful and angry) faces at 3 years of…”
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The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells by Sadava, David, Whitlock, Elizabeth, Kane, Susan E.

“…Epidemiological studies on humans and investigations in animal models suggest that consumption of green tea has anti-cancer effects. Small-cell lung carcinoma…”
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Security and Performance in IoT: A Balancing Act by Kane, Luke E., Chen, Jiaming James, Thomas, Rebecca, Liu, Vicky, Mckague, Matthew

“…With predictions suggesting there will be 18 billion Internet of Things (IoT) devices live by 2022, performance of these low powered devices, as well as…”
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Measurements of damage and repair of binary health attributes in aging mice and humans reveal that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions by Farrell, Spencer, Kane, Alice E, Bisset, Elise, Howlett, Susan E, Rutenberg, Andrew D

“…As an organism ages, its health-state is determined by a balance between the processes of damage and repair. Measuring these processes requires longitudinal…”
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