Search Results - "Kane, Daniel P."

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme by Xing, Xuanxuan, Kane, Daniel P., Bulock, Chelsea R., Moore, Elizabeth A., Sharma, Sushma, Chabes, Andrei, Shcherbakova, Polina V.

“…Alterations in the exonuclease domain of DNA polymerase ε (Polε) cause ultramutated tumors. Severe mutator effects of the most common variant, Polε-P286R,…”
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Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae by Barbari, Stephanie R, Kane, Daniel P, Moore, Elizabeth A, Shcherbakova, Polina V

“…DNA replication fidelity relies on base selectivity of the replicative DNA polymerases, exonucleolytic proofreading, and postreplicative DNA mismatch repair…”
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Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila by Kane, Daniel P, Shusterman, Michael, Rong, Yikang, McVey, Mitch

“…In metazoans, the mechanism by which DNA is synthesized during homologous recombination repair of double-strand breaks is poorly understood. Specifically, the…”
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A Common Cancer-Associated DNA Polymerase ε Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading by KANE, Daniel P, SHCHERBAKOVA, Polina V

“…Exonucleolytic proofreading and DNA mismatch repair (MMR) act in series to maintain high-fidelity DNA replication and to avoid mutagenesis. MMR defects elevate…”
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Super-sized deletions: Improved transposon excision screens using a mus309 mutant background by Witsell, Alice, Kane, Daniel P., McVey, Mitch

“…Over the past two decades, a large collection of transposable elements inserted at various locations in the Drosophila melanogaster genome has been assembled…”
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Removal of the Bloom Syndrome DNA Helicase Extends the Utility of Imprecise Transposon Excision for Making Null Mutations in Drosophila by Witsell, Alice, Kane, Daniel P, Rubin, Sarah, McVey, Mitch

“…Transposable elements are frequently used in Drosophila melanogaster for imprecise excision screens to delete genes of interest. However, these screens are…”
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State II Dissociation Element Formation Following Activator Excision in Maize by Conrad, Liza J, Bai, Ling, Ahern, Kevin, Dusinberre, Kelly, Kane, Daniel P, Brutnell, Thomas P

“…Active Activator (Ac) elements undergo mutations to become nonautonomous Dissociation (Ds) elements at a low frequency. To understand the mechanism of Ds…”
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Sophistry: A Promising Group Technique for the Involuntary Client by Evans, Timothy D, Kane, Daniel P

“…Describes sophistry, a group technique that examines the involuntary client's way of reasoning. This understanding forms the basis for subsequent group…”
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Multiple DNA polymerases act during homologous recombination repair in Drosophila melanogaster by Kane, Daniel P

“…Proper repair of DNA double-strand breaks is necessary for maintenance of genomic stability and prevention of genetic disorders. Breaks are repaired by two…”
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