Search Results - "Kandrakonda, Yelamanda Rao"
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Development of quinazolinone and vanillin acrylamide hybrids as multi-target directed ligands against Alzheimer's disease and mechanistic insights into their binding with acetylcholinesterase
Published in Journal of biomolecular structure & dynamics (21-12-2023)“…In view of Multi-Target Directed Ligand (MTDL) approach in treating Alzheimer's Disease (AD), a series of novel quinazolinone and vanillin cyanoacetamide based…”
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Quinazolinone–Hydrazine Cyanoacetamide Hybrids as Potent Multitarget-Directed Druggable Therapeutics against Alzheimer’s Disease: Design, Synthesis, and Biochemical, In Silico, and Mechanistic Analyses
Published in ACS chemical neuroscience (18-09-2024)“…The discovery of effective multitarget-directed ligands (MTDLs) against multifactorial Alzheimer’s disease (AD) remnants has been focused in an incessant drug…”
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Biosynthesis of zinc oxide nanoparticles using aqueous extract of Andrographis alata: Characterization, optimization and assessment of their antibacterial, antioxidant, antidiabetic and anti-Alzheimer's properties
Published in Journal of molecular structure (05-02-2023)“…•By using Andrographis alata aqueous extract zincoxide nanoparticles (ZnO NPs) were synthesized.•Biosynthesized A.alata ZnO NPs were characterized by UV–Vis,…”
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Synthesis and anti-Alzheimer potential of novel α-amino phosphonate derivatives and probing their molecular interaction mechanism with acetylcholinesterase
Published in European journal of medicinal chemistry (05-05-2023)“…Pleiotropic interference may be a prerequisite for the efficient limitation of the progression of multi-factorial diseases such as Alzheimer's disease (AD)…”
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Deciphering the AChE-binding mechanism with multifunctional tricyclic coumarin anti-Alzheimer's agents using biophysical and bioinformatics approaches and evaluation of their modulating effect on Amyloidogenic peptide assembly
Published in International journal of biological macromolecules (15-12-2021)“…Investigating the drug-AChE binding mechanism is vital in understanding its cogent use in medical practice against Alzheimer's disease (AD). The production and…”
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Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase
Published in Bioorganic chemistry (01-07-2019)“…[Display omitted] •A series of 7-methoxyflavone and cyanoacetamides hybrids (8a–q) were synthesized.•Synthetic analogs were evaluated for their AChE, BuChE,…”
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Synthesis and in vitro assessment of anticholinesterase and antioxidant properties of triazineamide derivatives
Published in Future medicinal chemistry (01-12-2022)“…Cholinesterase inhibitors and radical scavengers have been recognized as powerful symptomatic anti-Alzheimer's disease agents. Hence, the present study aimed…”
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